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- W4313590944 abstract "Abstract Background: Headache is among the most frequent symptoms of acute COVID-19 infection. Its mechanisms remain obscure, but due to its migraine-like characteristics, the activation of the trigeminal system could account for its underlying pathophysiology. Methods: Our aim was to compare the serum levels of CGRP, as a theoretical marker of trigemino-vascular activation, in 25 COVID-19 inpatients with lung involvement experiencing headache with those of 25 matched healthy controls with no headache history. Results: Morning serum alpha-CGRPα levels, as measured by ELISA (Abbexa, UK), were increased in COVID-19 patients with headache (55.2±34.3 pg/mL) vs controls (33.9±14.0 pg/mL) (p<0.01). Conclusions: CGRP levels are increased in COVID-19 patients experiencing headache in the acute phase of this disease, which could explain why headache frequently occurs in COVID-19 and strongly supports a role for trigeminal activation in the pathophysiology of headache in this viral infection." @default.
- W4313590944 created "2023-01-06" @default.
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- W4313590944 date "2023-01-04" @default.
- W4313590944 modified "2023-10-18" @default.
- W4313590944 title "Serum alpha-CGRP levels are increased in COVID-19 patients with headache indicating an activation of the trigeminal system" @default.
- W4313590944 doi "https://doi.org/10.21203/rs.3.rs-2072377/v1" @default.
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