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- W4313592317 abstract "Human Papilloma Virus is a major cause of cervical cancer. Recently more than 170 HPV genotypes have been identified. Therefore, the identification of HPV genotype is important for screening, therapy, and management of cervical cancer cases. As part of the national study of cervical cancer in Indonesia, the objective of this study is to identify HPV genotype among Indonesian urban women aged 25-64 years. All of 1,874 HPV-positive samples of cervical swabs collected in 2016 were examined for HPV genotypes using hybridization and PCR-hybridization methods. Univariate analysis was performed to obtain the proportion of each HPV genotype based on the sample characteristics. Twenty-seven HPV genotypes were successfully identified, consisting of 13 high-risk and 14 low-risk groups. For the HR group, the three dominant HPV genotypes were HPV-52, (18.5%), HPV-16 (16.6%) and HPV-18 (15.9%). The proportions of those three genotypes were varied among all sample characteristics. Two HPV genotypes of the LR group were HPV-43/44 and HPV-42. Most of the HPV infections were caused by a single HPV genotype, with a proportion of 86%. The discovery of those three HR groups among women in the community may have a high potential risk to cause cervical cancer diseases, therefore, preventive measures such as community screening and HPV genotyping are required as well as HPV vaccination particularly for the risk groups." @default.
- W4313592317 created "2023-01-06" @default.
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- W4313592317 date "2023-01-01" @default.
- W4313592317 modified "2023-10-16" @default.
- W4313592317 title "Three dominant genotypes of human papilloma virus among Indonesian urban women" @default.
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- W4313592317 doi "https://doi.org/10.1063/5.0119065" @default.
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