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- W4313592464 abstract "An Indonesia soil actinomycete, Streptomyces sp. BioMCC-a.T.3335 was cultured to find compounds that showing inhibitory activity against Plasmodium falciparum cell proliferation. The properties of active compounds in the extract were examined by conducting a preliminary extraction test (PET). Extraction and purification method of active compounds was developed based on PET result. We identified two active compounds, cosmomycin A (1) and B (2), from the extract as active compounds. Cosmomycin A inhibited the proliferation of P. falciparum 3D7 cell in vitro (IC50=2.8 nM). To our best knowledge, 1 and 2 have never been reported as anti-malarial agents before." @default.
- W4313592464 created "2023-01-06" @default.
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- W4313592464 date "2023-01-01" @default.
- W4313592464 modified "2023-10-01" @default.
- W4313592464 title "Isolation of antimalarial active compound derived from Indonesian soil actinomycete Streptomyces sp. BioMCC-a.T.3335" @default.
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- W4313592464 doi "https://doi.org/10.1063/5.0118369" @default.
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