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- W4313593011 abstract "We present the rationale for testing ketamine as an add-on therapy for treating benzodiazepine refractory (established) status epilepticus. In animal studies, ketamine terminates benzodiazepine refractory status epilepticus by interfering with the pathophysiological mechanisms and is a neuroprotectant. Ketamine does not suppress respiration when used for sedation and anesthesia. A Series of reports suggest that ketamine can help terminate refractory and super refractory status epilepticus. We propose to use 1 or 3 mg/Kg ketamine intravenously based on animal-to-human conversion and pharmacokinetic studies. This paper was presented at the 8th London-Innsbruck Colloquium on Status Epilepticus and Acute Seizures held in September 2022." @default.
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- W4313593011 date "2023-04-01" @default.
- W4313593011 modified "2023-09-23" @default.
- W4313593011 title "Why ketamine" @default.
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- W4313593011 doi "https://doi.org/10.1016/j.yebeh.2022.109066" @default.
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