FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313593053> ?p ?o ?g. }

• W4313593053 endingPage "504" @default.
• W4313593053 startingPage "493" @default.
• W4313593053 abstract "Leucine increases protein synthesis rates in postnatal animals and adults. Whether supplemental leucine has similar effects in the fetus has not been determined. To determine the effect of a chronic leucine infusion on whole-body leucine oxidation and protein metabolic rates, muscle mass, and regulators of muscle protein synthesis in late gestation fetal sheep. Catheterized fetal sheep at ∼126 d of gestation (term = 147 d) received infusions of saline (CON, n = 11) or leucine (LEU; n = 9) adjusted to increase fetal plasma leucine concentrations by 50%–100% for 9 d. Umbilical substrate net uptake rates and protein metabolic rates were determined using a 1-13C leucine tracer. Myofiber myosin heavy chain (MHC) type and area, expression of amino acid transporters, and abundance of protein synthesis regulators were measured in fetal skeletal muscle. Groups were compared using unpaired t tests. Plasma leucine concentrations were 75% higher in LEU fetuses compared with CON by the end of the infusion period (P < 0.0001). Umbilical blood flow and uptake rates of most amino acids, lactate, and oxygen were similar between groups. Fetal whole-body leucine oxidation was 90% higher in LEU (P < 0.0005) but protein synthesis and breakdown rates were similar. Fetal and muscle weights and myofiber areas were similar between groups, however, there were fewer MHC type IIa fibers (P < 0.05), greater mRNA expression levels of amino acid transporters (P < 0.01), and a higher abundance of signaling proteins that regulate protein synthesis (P < 0.05) in muscle from LEU fetuses. A direct leucine infusion for 9 d in late gestation fetal sheep does not increase protein synthesis rates but results in higher leucine oxidation rates and fewer glycolytic myofibers. Increasing leucine concentrations in the fetus stimulates its own oxidation but also increases amino acid transporter expression and primes protein synthetic pathways in skeletal muscle." @default.
• W4313593053 created "2023-01-06" @default.
• W4313593053 creator A5007506451 @default.
• W4313593053 creator A5014658146 @default.
• W4313593053 creator A5015495714 @default.
• W4313593053 creator A5049773569 @default.
• W4313593053 creator A5062138185 @default.
• W4313593053 date "2023-02-01" @default.
• W4313593053 modified "2023-10-14" @default.
• W4313593053 title "Chronic Fetal Leucine Infusion Increases Rate of Leucine Oxidation but Not of Protein Synthesis in Late Gestation Fetal Sheep" @default.
• W4313593053 cites W1495487817 @default.
• W4313593053 cites W1907574285 @default.
• W4313593053 cites W1908039135 @default.
• W4313593053 cites W1926066807 @default.
• W4313593053 cites W1937701470 @default.
• W4313593053 cites W1945012169 @default.
• W4313593053 cites W1946555313 @default.
• W4313593053 cites W1976395092 @default.
• W4313593053 cites W1979551722 @default.
• W4313593053 cites W1980600921 @default.
• W4313593053 cites W1985481640 @default.
• W4313593053 cites W1985664628 @default.
• W4313593053 cites W2003453262 @default.
• W4313593053 cites W2004582874 @default.
• W4313593053 cites W2008239768 @default.
• W4313593053 cites W2011079767 @default.
• W4313593053 cites W2020049342 @default.
• W4313593053 cites W2021309399 @default.
• W4313593053 cites W2022279807 @default.
• W4313593053 cites W2025176940 @default.
• W4313593053 cites W2029638569 @default.
• W4313593053 cites W2039503336 @default.
• W4313593053 cites W2040149443 @default.
• W4313593053 cites W2049069390 @default.
• W4313593053 cites W2077348052 @default.
• W4313593053 cites W2095471290 @default.
• W4313593053 cites W2097855132 @default.
• W4313593053 cites W2101921236 @default.
• W4313593053 cites W2106637677 @default.
• W4313593053 cites W2113387156 @default.
• W4313593053 cites W2114769835 @default.
• W4313593053 cites W2118767476 @default.
• W4313593053 cites W2119194577 @default.
• W4313593053 cites W2122074109 @default.
• W4313593053 cites W2122749842 @default.
• W4313593053 cites W2122778637 @default.
• W4313593053 cites W2123231624 @default.
• W4313593053 cites W2124569381 @default.
• W4313593053 cites W2126265811 @default.
• W4313593053 cites W2135532864 @default.
• W4313593053 cites W2136282778 @default.
• W4313593053 cites W2136954505 @default.
• W4313593053 cites W2137789014 @default.
• W4313593053 cites W2139124120 @default.
• W4313593053 cites W2146803933 @default.
• W4313593053 cites W2148932398 @default.
• W4313593053 cites W2149160265 @default.
• W4313593053 cites W2151185613 @default.
• W4313593053 cites W2159179046 @default.
• W4313593053 cites W2159880697 @default.
• W4313593053 cites W2161093056 @default.
• W4313593053 cites W2163563813 @default.
• W4313593053 cites W2167620866 @default.
• W4313593053 cites W2194279484 @default.
• W4313593053 cites W2237658690 @default.
• W4313593053 cites W2239045846 @default.
• W4313593053 cites W2239103220 @default.
• W4313593053 cites W2264407089 @default.
• W4313593053 cites W2269683760 @default.
• W4313593053 cites W2275260036 @default.
• W4313593053 cites W2302484695 @default.
• W4313593053 cites W2313685424 @default.
• W4313593053 cites W2400029316 @default.
• W4313593053 cites W2412883775 @default.
• W4313593053 cites W2472419928 @default.
• W4313593053 cites W2760136244 @default.
• W4313593053 cites W2806782357 @default.
• W4313593053 cites W2946428766 @default.
• W4313593053 cites W3029903435 @default.
• W4313593053 cites W3046941773 @default.
• W4313593053 cites W3111146373 @default.
• W4313593053 cites W3120524507 @default.
• W4313593053 cites W3154114020 @default.
• W4313593053 cites W3185863978 @default.
• W4313593053 cites W4296816736 @default.
• W4313593053 cites W4383997435 @default.
• W4313593053 cites W593983346 @default.
• W4313593053 cites W70886552 @default.
• W4313593053 doi "https://doi.org/10.1016/j.tjnut.2022.12.027" @default.
• W4313593053 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36894241" @default.
• W4313593053 hasPublicationYear "2023" @default.
• W4313593053 type Work @default.
• W4313593053 citedByCount "0" @default.
• W4313593053 crossrefType "journal-article" @default.
• W4313593053 hasAuthorship W4313593053A5007506451 @default.
• W4313593053 hasAuthorship W4313593053A5014658146 @default.
• W4313593053 hasAuthorship W4313593053A5015495714 @default.
• W4313593053 hasAuthorship W4313593053A5049773569 @default.

• next