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- W4313593617 endingPage "1107" @default.
- W4313593617 startingPage "1094" @default.
- W4313593617 abstract "Tissue resident memory T cells (TRM cells) can provide effective tissue surveillance and can respond rapidly to infection. Vaccination strategies aimed at generating TRM cells have shown promise against a range of pathogens. We have previously shown that the choice of adjuvant critically influences CD8+ TRM cell formation in the liver. However, the range of adjuvants tested was limited. Here, we assessed the ability of a broad range of adjuvants stimulating membrane (TLR4), endosomal (TLR3, TLR7 and TLR9) and cytosolic (cGAS, RIG-I) pathogen recognition receptors for their capacity to induce CD8+ TRM formation in a subunit vaccination model. We show that CpG oligodeoxynucleotides (ODN) remain the most efficient inducers of liver TRM cells among all adjuvants tested. Moreover, their combination with the cationic liposome DOTAP further enhances the potency, particularly of the class B ODN CpG 1668 and the human TLR9 ligand CpG 2006 (CpG 7909). This study informs the design of efficient liver TRM-based vaccines for their potential translation." @default.
- W4313593617 created "2023-01-06" @default.
- W4313593617 creator A5011411767 @default.
- W4313593617 creator A5019646480 @default.
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- W4313593617 creator A5051844096 @default.
- W4313593617 creator A5066813901 @default.
- W4313593617 creator A5069004055 @default.
- W4313593617 creator A5077542365 @default.
- W4313593617 date "2023-01-01" @default.
- W4313593617 modified "2023-10-15" @default.
- W4313593617 title "Complexing CpG adjuvants with cationic liposomes enhances vaccine-induced formation of liver TRM cells" @default.
- W4313593617 cites W1176162522 @default.
- W4313593617 cites W1514540900 @default.
- W4313593617 cites W1526920493 @default.
- W4313593617 cites W1534709281 @default.
- W4313593617 cites W1584203472 @default.
- W4313593617 cites W1629378057 @default.
- W4313593617 cites W1856321184 @default.
- W4313593617 cites W1940498497 @default.
- W4313593617 cites W1960924921 @default.
- W4313593617 cites W1964163749 @default.
- W4313593617 cites W1964493928 @default.
- W4313593617 cites W1969072247 @default.
- W4313593617 cites W1972776583 @default.
- W4313593617 cites W1975739500 @default.
- W4313593617 cites W1981087308 @default.
- W4313593617 cites W1985999816 @default.
- W4313593617 cites W1990273429 @default.
- W4313593617 cites W1995744610 @default.
- W4313593617 cites W1996229570 @default.
- W4313593617 cites W2000046662 @default.
- W4313593617 cites W2006760510 @default.
- W4313593617 cites W2016131266 @default.
- W4313593617 cites W2016525911 @default.
- W4313593617 cites W2017515700 @default.
- W4313593617 cites W2030378290 @default.
- W4313593617 cites W2032948492 @default.
- W4313593617 cites W2039551908 @default.
- W4313593617 cites W2040101069 @default.
- W4313593617 cites W2041267131 @default.
- W4313593617 cites W2045101135 @default.
- W4313593617 cites W2048069351 @default.
- W4313593617 cites W2049247030 @default.
- W4313593617 cites W2049490137 @default.
- W4313593617 cites W2052521175 @default.
- W4313593617 cites W2053135095 @default.
- W4313593617 cites W2066825944 @default.
- W4313593617 cites W2069981713 @default.
- W4313593617 cites W2074161152 @default.
- W4313593617 cites W2076361525 @default.
- W4313593617 cites W2076530076 @default.
- W4313593617 cites W2080456371 @default.
- W4313593617 cites W2082865800 @default.
- W4313593617 cites W2095224835 @default.
- W4313593617 cites W2095399328 @default.
- W4313593617 cites W2099465341 @default.
- W4313593617 cites W2099610218 @default.
- W4313593617 cites W2100313593 @default.
- W4313593617 cites W2100609582 @default.
- W4313593617 cites W2104525960 @default.
- W4313593617 cites W2107955975 @default.
- W4313593617 cites W2108765339 @default.
- W4313593617 cites W2110223801 @default.
- W4313593617 cites W2115161796 @default.
- W4313593617 cites W2123955674 @default.
- W4313593617 cites W2125566625 @default.
- W4313593617 cites W2128305305 @default.
- W4313593617 cites W2128657286 @default.
- W4313593617 cites W2129319296 @default.
- W4313593617 cites W2135218342 @default.
- W4313593617 cites W2136187101 @default.
- W4313593617 cites W2141120240 @default.
- W4313593617 cites W2146824929 @default.
- W4313593617 cites W2152367839 @default.
- W4313593617 cites W2155168075 @default.
- W4313593617 cites W2158487508 @default.
- W4313593617 cites W2161253720 @default.
- W4313593617 cites W2162538566 @default.
- W4313593617 cites W2165667030 @default.
- W4313593617 cites W2166386800 @default.
- W4313593617 cites W2169678660 @default.
- W4313593617 cites W2173086864 @default.
- W4313593617 cites W2340670258 @default.
- W4313593617 cites W2426132557 @default.
- W4313593617 cites W2525642000 @default.
- W4313593617 cites W2549771086 @default.
- W4313593617 cites W2580868078 @default.
- W4313593617 cites W2589014995 @default.
- W4313593617 cites W2599276599 @default.
- W4313593617 cites W2604891050 @default.
- W4313593617 cites W2615971685 @default.
- W4313593617 cites W2743873195 @default.
- W4313593617 cites W275308703 @default.