FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313593764> ?p ?o ?g. }

• W4313593764 endingPage "538" @default.
• W4313593764 startingPage "529" @default.
• W4313593764 abstract "Probiotics are suggested to improve depressive symptoms via the microbiota-gut-brain axis. We have recently shown a beneficial clinical effect of probiotic supplementation in patients with depression. Their underlying neural mechanisms remain unknown. A multimodal neuroimaging approach including diffusion tensor imaging, resting-state functional MRI, and arterial spin labeling was used to investigate the effects of a four-weeks probiotic supplementation on fronto-limbic brain structure, function, and perfusion and whether these effects were related to symptom changes. Thirty-two patients completed both imaging assessments (18 placebo and 14 probiotics group). Probiotics maintained mean diffusivity in the left uncinate fasciculus, stabilized it in the right uncinate fasciculus, and altered resting-state functional connectivity (rsFC) between limbic structures and the temporal pole to a cluster in the precuneus. Moreover, a cluster in the left superior parietal lobule showed altered rsFC to the subcallosal cortex, the left orbitofrontal cortex, and limbic structures after probiotics. In the probiotics group, structural and functional changes were partly related to decreases in depressive symptoms. This study has a rather small sample size. An additional follow-up MRI session would be interesting for seeing clearer changes in the relevant brain regions as clinical effects were strongest in the follow-up. Probiotic supplementation is suggested to prevent neuronal degeneration along the uncinate fasciculus and alter fronto-limbic rsFC, effects that are partly related to the improvement of depressive symptoms. Elucidating the neural mechanisms underlying probiotics' clinical effects on depression provide potential targets for the development of more precise probiotic treatments." @default.
• W4313593764 created "2023-01-06" @default.
• W4313593764 creator A5000997517 @default.
• W4313593764 creator A5009127344 @default.
• W4313593764 creator A5014706007 @default.
• W4313593764 creator A5016889478 @default.
• W4313593764 creator A5036855509 @default.
• W4313593764 creator A5038498547 @default.
• W4313593764 creator A5041335052 @default.
• W4313593764 creator A5042270764 @default.
• W4313593764 creator A5047606802 @default.
• W4313593764 creator A5054234763 @default.
• W4313593764 creator A5072323649 @default.
• W4313593764 creator A5088034374 @default.
• W4313593764 date "2023-03-01" @default.
• W4313593764 modified "2023-10-13" @default.
• W4313593764 title "Effects of a probiotic add-on treatment on fronto-limbic brain structure, function, and perfusion in depression: Secondary neuroimaging findings of a randomized controlled trial" @default.
• W4313593764 cites W1582811168 @default.
• W4313593764 cites W1768927256 @default.
• W4313593764 cites W1970006078 @default.
• W4313593764 cites W1970587672 @default.
• W4313593764 cites W1973776237 @default.
• W4313593764 cites W1977610079 @default.
• W4313593764 cites W1978660262 @default.
• W4313593764 cites W1981500982 @default.
• W4313593764 cites W1983183519 @default.
• W4313593764 cites W1986269945 @default.
• W4313593764 cites W1986779034 @default.
• W4313593764 cites W1988235609 @default.
• W4313593764 cites W1992735022 @default.
• W4313593764 cites W1993445932 @default.
• W4313593764 cites W1994160738 @default.
• W4313593764 cites W2004044223 @default.
• W4313593764 cites W2006096283 @default.
• W4313593764 cites W2026812901 @default.
• W4313593764 cites W2026904697 @default.
• W4313593764 cites W2027721376 @default.
• W4313593764 cites W2028905751 @default.
• W4313593764 cites W2059177186 @default.
• W4313593764 cites W2061378977 @default.
• W4313593764 cites W2064359303 @default.
• W4313593764 cites W2064857678 @default.
• W4313593764 cites W2067321748 @default.
• W4313593764 cites W2071881327 @default.
• W4313593764 cites W2073695929 @default.
• W4313593764 cites W2076793624 @default.
• W4313593764 cites W2081237186 @default.
• W4313593764 cites W2085105520 @default.
• W4313593764 cites W2092703451 @default.
• W4313593764 cites W2095438393 @default.
• W4313593764 cites W2101135654 @default.
• W4313593764 cites W2105119061 @default.
• W4313593764 cites W2105757186 @default.
• W4313593764 cites W2108337682 @default.
• W4313593764 cites W2110431535 @default.
• W4313593764 cites W2115964617 @default.
• W4313593764 cites W2120471995 @default.
• W4313593764 cites W2122506124 @default.
• W4313593764 cites W2131398580 @default.
• W4313593764 cites W2133371501 @default.
• W4313593764 cites W2135025386 @default.
• W4313593764 cites W2142658283 @default.
• W4313593764 cites W2144538553 @default.
• W4313593764 cites W2146747402 @default.
• W4313593764 cites W2147969224 @default.
• W4313593764 cites W2151041365 @default.
• W4313593764 cites W2162391751 @default.
• W4313593764 cites W2164342861 @default.
• W4313593764 cites W2165109833 @default.
• W4313593764 cites W2166326266 @default.
• W4313593764 cites W2167738136 @default.
• W4313593764 cites W2213331525 @default.
• W4313593764 cites W2292048640 @default.
• W4313593764 cites W2332657696 @default.
• W4313593764 cites W2337492846 @default.
• W4313593764 cites W2407586042 @default.
• W4313593764 cites W2478760258 @default.
• W4313593764 cites W2521795478 @default.
• W4313593764 cites W2551779329 @default.
• W4313593764 cites W2627093176 @default.
• W4313593764 cites W2755198076 @default.
• W4313593764 cites W2758113150 @default.
• W4313593764 cites W2769738264 @default.
• W4313593764 cites W2791861226 @default.
• W4313593764 cites W2805619619 @default.
• W4313593764 cites W2885072544 @default.
• W4313593764 cites W2896970273 @default.
• W4313593764 cites W2970275262 @default.
• W4313593764 cites W2970686316 @default.
• W4313593764 cites W2974174249 @default.
• W4313593764 cites W2999785229 @default.
• W4313593764 cites W3017160392 @default.
• W4313593764 cites W3034707607 @default.
• W4313593764 cites W3093051135 @default.
• W4313593764 cites W3101254306 @default.
• W4313593764 cites W3163647506 @default.
• W4313593764 cites W4281776018 @default.
• W4313593764 doi "https://doi.org/10.1016/j.jad.2022.12.142" @default.

• next