Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313593822> ?p ?o ?g. }
- W4313593822 endingPage "109659" @default.
- W4313593822 startingPage "109659" @default.
- W4313593822 abstract "Hyperactivity of HPA axis results in intestinal dysfunction, which may play a role in brain injury caused by ischemic stroke (IS). Escin shows a neuroprotective effect but it may not penetrate blood brain barrier (BBB). Previous work in our laboratory showed that escin ameliorated intestinal injury in animals. The aim of this study is to investigate whether escin attenuates brain injury by improving intestinal dysfunction in middle cerebral artery occlusion (MCAO) rats, to mimic IS. MCAO rats and lipopolysaccharides (LPS)-induced Caco-2 cells were used to evaluate the effects of escin in vivo and in vitro. The results showed that escin could not penetrate BBB but reduced brain infarct volume, improved neurological function, inhibited neuroinflammation, ameliorated intestinal dysfunction and tissue integrity by increasing the expression of the tight junction protein in vivo and in vitro. Escin reduced the increased corticosterone and endotoxin level in blood of MCAO rats, regulated GR/p38 MAPK/NF-κB signaling pathway in ileal tissue and LPS/TLR4/NF-κB signaling pathway in ischemic brain tissue. These findings suggest that escin could attenuate ischemic brain injury by improving intestinal dysfunction, and it may be a promising way to protect brain injury by protecting intestine, instead of targeting the brain directly after IS." @default.
- W4313593822 created "2023-01-06" @default.
- W4313593822 creator A5010624632 @default.
- W4313593822 creator A5020330114 @default.
- W4313593822 creator A5041232755 @default.
- W4313593822 creator A5045858633 @default.
- W4313593822 creator A5055686200 @default.
- W4313593822 creator A5074206319 @default.
- W4313593822 creator A5080495628 @default.
- W4313593822 date "2023-02-01" @default.
- W4313593822 modified "2023-10-01" @default.
- W4313593822 title "Escin alleviates stress-induced intestinal dysfunction to protect brain injury by regulating the gut-brain axis in ischemic stroke rats" @default.
- W4313593822 cites W1489339892 @default.
- W4313593822 cites W1965176866 @default.
- W4313593822 cites W1974912634 @default.
- W4313593822 cites W2015443697 @default.
- W4313593822 cites W2026474962 @default.
- W4313593822 cites W2038833685 @default.
- W4313593822 cites W2051340348 @default.
- W4313593822 cites W2056879548 @default.
- W4313593822 cites W2072167325 @default.
- W4313593822 cites W2076999463 @default.
- W4313593822 cites W2156873270 @default.
- W4313593822 cites W2171783221 @default.
- W4313593822 cites W2220425927 @default.
- W4313593822 cites W2284905061 @default.
- W4313593822 cites W2567810317 @default.
- W4313593822 cites W2577038661 @default.
- W4313593822 cites W2600495731 @default.
- W4313593822 cites W2729439965 @default.
- W4313593822 cites W2742964185 @default.
- W4313593822 cites W2790416725 @default.
- W4313593822 cites W2804081205 @default.
- W4313593822 cites W2807153072 @default.
- W4313593822 cites W2808277102 @default.
- W4313593822 cites W2907957406 @default.
- W4313593822 cites W2948338353 @default.
- W4313593822 cites W2975664970 @default.
- W4313593822 cites W2979256511 @default.
- W4313593822 cites W2981720404 @default.
- W4313593822 cites W2987356303 @default.
- W4313593822 cites W2998207892 @default.
- W4313593822 cites W3009682272 @default.
- W4313593822 cites W3017853167 @default.
- W4313593822 cites W3024106591 @default.
- W4313593822 cites W3031696415 @default.
- W4313593822 cites W3033017339 @default.
- W4313593822 cites W3036177086 @default.
- W4313593822 cites W3036454441 @default.
- W4313593822 cites W3037191470 @default.
- W4313593822 cites W3037474388 @default.
- W4313593822 cites W3092353927 @default.
- W4313593822 cites W3111639624 @default.
- W4313593822 cites W3118406134 @default.
- W4313593822 cites W3124670188 @default.
- W4313593822 cites W3130775255 @default.
- W4313593822 cites W3173739556 @default.
- W4313593822 cites W3174109837 @default.
- W4313593822 cites W3179532800 @default.
- W4313593822 cites W3216930162 @default.
- W4313593822 cites W4221058800 @default.
- W4313593822 cites W4292087133 @default.
- W4313593822 doi "https://doi.org/10.1016/j.intimp.2022.109659" @default.
- W4313593822 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36608442" @default.
- W4313593822 hasPublicationYear "2023" @default.
- W4313593822 type Work @default.
- W4313593822 citedByCount "3" @default.
- W4313593822 countsByYear W43135938222023 @default.
- W4313593822 crossrefType "journal-article" @default.
- W4313593822 hasAuthorship W4313593822A5010624632 @default.
- W4313593822 hasAuthorship W4313593822A5020330114 @default.
- W4313593822 hasAuthorship W4313593822A5041232755 @default.
- W4313593822 hasAuthorship W4313593822A5045858633 @default.
- W4313593822 hasAuthorship W4313593822A5055686200 @default.
- W4313593822 hasAuthorship W4313593822A5074206319 @default.
- W4313593822 hasAuthorship W4313593822A5080495628 @default.
- W4313593822 hasConcept C118552586 @default.
- W4313593822 hasConcept C126322002 @default.
- W4313593822 hasConcept C127413603 @default.
- W4313593822 hasConcept C150903083 @default.
- W4313593822 hasConcept C207001950 @default.
- W4313593822 hasConcept C25498285 @default.
- W4313593822 hasConcept C2776070231 @default.
- W4313593822 hasConcept C2776914184 @default.
- W4313593822 hasConcept C2778402981 @default.
- W4313593822 hasConcept C2780645631 @default.
- W4313593822 hasConcept C2781017439 @default.
- W4313593822 hasConcept C529278444 @default.
- W4313593822 hasConcept C541997718 @default.
- W4313593822 hasConcept C71924100 @default.
- W4313593822 hasConcept C78519656 @default.
- W4313593822 hasConcept C86803240 @default.
- W4313593822 hasConcept C87753298 @default.
- W4313593822 hasConcept C98274493 @default.
- W4313593822 hasConceptScore W4313593822C118552586 @default.
- W4313593822 hasConceptScore W4313593822C126322002 @default.
- W4313593822 hasConceptScore W4313593822C127413603 @default.
- W4313593822 hasConceptScore W4313593822C150903083 @default.