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- W4313593892 abstract "Administration of morphine is associated with critical complications in clinic which primarily includes the development of dependence and tolerance even following a single dose (acute) exposure. Behavioral and electrophysiological studies support the significant role of locus coeruleus (LC) neurons in tolerance and dependence following chronic morphine exposure. The current study was designed to explore the electrophysiological properties of the LC neurons following acute morphine exposure. In-vitro whole-cell patch-clamp recordings were performed in LC neurons 24 h after intraperitoneal morphine injection. Acute morphine injection significantly decreased the spontaneous firing rate of LC neurons, the rising and decay slopes of action potentials, and consequently increased the action potential duration. In addition, morphine treatment did not alter the rheobase current and first spike latency while affected the inhibitory postsynaptic currents elicited in response to orexin-A. In fact, single morphine exposure could inhibit the disinhibitory effect of orexin-A on LC neurons." @default.
- W4313593892 created "2023-01-06" @default.
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- W4313593892 date "2023-01-01" @default.
- W4313593892 modified "2023-09-23" @default.
- W4313593892 title "Acute morphine injection persistently affects the electrophysiological characteristics of rat locus coeruleus neurons" @default.
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- W4313593892 doi "https://doi.org/10.1016/j.neulet.2023.137048" @default.
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