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• W4313594037 endingPage "112121" @default.
• W4313594037 startingPage "112121" @default.
• W4313594037 abstract "Five ternary copper(II) complexes, [Cu2(phen)2(L1)(ClO4)2] (1), [Cu2(phen)2(L1)(DMSO)2](PF6)2 (2), [Cu2(bpy)2(L1)(ClO4)2(H2O)2] (3), [Cu2(dmp)2(L1)(ClO4)2(H2O)2] (4), and [Cu(phen)(L2)]2(ClO4)2 (5), in which phen = 1,10-phenanthroline, bpy = 2,2′-bipyridine, dmp = 2,9-dimethyl-1,10-phenanthroline, H2L1 = 1,4-dihydroxyanthracene-9,10-dione and HL2 = 1-hydroxyanthracene-9,10-dione, DMSO = dimethylsulfoxide, were synthesized and fully characterized. Complex 2 was obtained through the substitution of perchlorate for DMSO. When two hydroxyquinone groups are present, L1 makes a bridge between two Cu(II) ions, which also bind two nitrogens of the respective diimine ligand. The compounds bind to calf thymus DNA and oxidatively cleave pUC19 DNA according to the following order of activity 1 > 4–5 > 3. Furthermore, complexes 1, 3, 4 and 5 inhibit topoisomerase-I activity and the growth of myelogenous leukemia cells with the IC50 values of 1.13, 10.60, 0.078, and 1.84 μmol L−1, respectively. Complexes 1 and 4 are the most active in cancer cells and in DNA cleavage." @default.
• W4313594037 created "2023-01-06" @default.
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• W4313594037 date "2023-04-01" @default.
• W4313594037 modified "2023-09-23" @default.
• W4313594037 title "Antitumor copper(II) complexes with hydroxyanthraquinones and N,N-heterocyclic ligands" @default.
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• W4313594037 doi "https://doi.org/10.1016/j.jinorgbio.2023.112121" @default.
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