Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313594092> ?p ?o ?g. }
- W4313594092 endingPage "104060" @default.
- W4313594092 startingPage "104060" @default.
- W4313594092 abstract "Previous studies have associated bisphenol A (BPA) with malignant tumor formation, infertility, and atherosclerosis in vitro and in vivo. However, the precise mechanisms through which BPA affects the cardiovascular system under normal conditions remain unclear. Therefore, this study investigated the biological mechanisms through which BPA affects the responses of aortic vascular smooth muscle cells (VSMCs). BPA treatment inhibited the proliferative activity of VSMCs and induced G2/M-phase cell cycle arrest via stimulation of the ATM-CHK2-Cdc25C-p21WAF1-Cdc2 cascade in VSMCs. Furthermore, BPA treatment upregulated the phosphorylation of mitogen-activated protein kinase (MAPK) pathways such as ERK, JNK, and p38 MAPK in VSMCs. However, the phosphorylation level of AKT was down-regulated by BPA treatment. Additionally, the phosphorylation of ERK, JNK, and p38 MAPK was suppressed when the cells were treated with their respective inhibitors (U0126, SP600125, and SB203580). BPA suppressed MMP-9 activity by reducing the binding activity of AP-1, Sp-1, and NF-κB, thus inhibiting the invasive and migratory ability of VSMCs. These data demonstrate that BPA interferes with the proliferation, migration, and invasion capacities of VSMCs. Therefore, our findings suggest that overexposure to BPA can lead to cardiovascular damage due to dysregulated VSMC responses." @default.
- W4313594092 created "2023-01-06" @default.
- W4313594092 creator A5010936911 @default.
- W4313594092 creator A5021094445 @default.
- W4313594092 creator A5022028069 @default.
- W4313594092 creator A5024208790 @default.
- W4313594092 creator A5028262111 @default.
- W4313594092 creator A5066587325 @default.
- W4313594092 creator A5080001926 @default.
- W4313594092 date "2023-03-01" @default.
- W4313594092 modified "2023-10-16" @default.
- W4313594092 title "Bisphenol A exposure inhibits vascular smooth muscle cell responses: Involvement of proliferation, migration, and invasion" @default.
- W4313594092 cites W1547736903 @default.
- W4313594092 cites W1961885071 @default.
- W4313594092 cites W1962995704 @default.
- W4313594092 cites W1973152525 @default.
- W4313594092 cites W1984634361 @default.
- W4313594092 cites W1986289302 @default.
- W4313594092 cites W1989960045 @default.
- W4313594092 cites W1993744150 @default.
- W4313594092 cites W1996405087 @default.
- W4313594092 cites W2000699007 @default.
- W4313594092 cites W2004475371 @default.
- W4313594092 cites W2007114641 @default.
- W4313594092 cites W2028922137 @default.
- W4313594092 cites W2034556762 @default.
- W4313594092 cites W2052016827 @default.
- W4313594092 cites W2060016622 @default.
- W4313594092 cites W2064460865 @default.
- W4313594092 cites W2083440158 @default.
- W4313594092 cites W2089473708 @default.
- W4313594092 cites W2102353246 @default.
- W4313594092 cites W2146428402 @default.
- W4313594092 cites W2160240007 @default.
- W4313594092 cites W2162830803 @default.
- W4313594092 cites W2170425387 @default.
- W4313594092 cites W2193328303 @default.
- W4313594092 cites W2276006579 @default.
- W4313594092 cites W2309243177 @default.
- W4313594092 cites W2415141352 @default.
- W4313594092 cites W2551387324 @default.
- W4313594092 cites W2555951466 @default.
- W4313594092 cites W2620539305 @default.
- W4313594092 cites W2701879287 @default.
- W4313594092 cites W2788473017 @default.
- W4313594092 cites W2789450469 @default.
- W4313594092 cites W2836174168 @default.
- W4313594092 cites W2889322279 @default.
- W4313594092 cites W2892017498 @default.
- W4313594092 cites W2895097849 @default.
- W4313594092 cites W2903359500 @default.
- W4313594092 cites W2913004829 @default.
- W4313594092 cites W2915767933 @default.
- W4313594092 cites W2934384318 @default.
- W4313594092 cites W2963216619 @default.
- W4313594092 cites W2972797149 @default.
- W4313594092 cites W2982356922 @default.
- W4313594092 cites W2991303641 @default.
- W4313594092 cites W3045365805 @default.
- W4313594092 cites W3082956607 @default.
- W4313594092 cites W3096443882 @default.
- W4313594092 cites W3166491721 @default.
- W4313594092 cites W3191427920 @default.
- W4313594092 cites W3211348963 @default.
- W4313594092 cites W4220925574 @default.
- W4313594092 cites W4246532997 @default.
- W4313594092 doi "https://doi.org/10.1016/j.etap.2023.104060" @default.
- W4313594092 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36610522" @default.
- W4313594092 hasPublicationYear "2023" @default.
- W4313594092 type Work @default.
- W4313594092 citedByCount "0" @default.
- W4313594092 crossrefType "journal-article" @default.
- W4313594092 hasAuthorship W4313594092A5010936911 @default.
- W4313594092 hasAuthorship W4313594092A5021094445 @default.
- W4313594092 hasAuthorship W4313594092A5022028069 @default.
- W4313594092 hasAuthorship W4313594092A5024208790 @default.
- W4313594092 hasAuthorship W4313594092A5028262111 @default.
- W4313594092 hasAuthorship W4313594092A5066587325 @default.
- W4313594092 hasAuthorship W4313594092A5080001926 @default.
- W4313594092 hasConcept C104317684 @default.
- W4313594092 hasConcept C11960822 @default.
- W4313594092 hasConcept C120504264 @default.
- W4313594092 hasConcept C126322002 @default.
- W4313594092 hasConcept C127561419 @default.
- W4313594092 hasConcept C134018914 @default.
- W4313594092 hasConcept C1491633281 @default.
- W4313594092 hasConcept C184235292 @default.
- W4313594092 hasConcept C185592680 @default.
- W4313594092 hasConcept C2779395532 @default.
- W4313594092 hasConcept C29537977 @default.
- W4313594092 hasConcept C2992686903 @default.
- W4313594092 hasConcept C502942594 @default.
- W4313594092 hasConcept C51551487 @default.
- W4313594092 hasConcept C55493867 @default.
- W4313594092 hasConcept C57074206 @default.
- W4313594092 hasConcept C62112901 @default.
- W4313594092 hasConcept C71924100 @default.
- W4313594092 hasConcept C75217442 @default.