FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313594771> ?p ?o ?g. }

• W4313594771 endingPage "109502" @default.
• W4313594771 startingPage "109502" @default.
• W4313594771 abstract "Necroptosis has been demonstrated to contribute to brain injury in ischemic stroke, whereas A20 can exert anti-necroptosis effect via deubiquitinating receptor-interacting protein kinase (RIPK3) at k63 and it can be cleaved by MALT1. This study aims to explore whether MALT1 is upregulated in the brain during ischemic stroke and promotes brain cell necroptosis through enhancing the degradation of A20. Ischemic stroke model was established in Sprague Dawley rats by occlusion of the middle cerebral artery (MCA) for 2 h, followed by 24 h reperfusion, which showed brain injury (increase in neurological deficit score and infarct volume) concomitant with an upregulation of MALT1, a decrease in A20 level, and increases in necroptosis-associated protein levels [RIPK3, mixed lineage kinase domain-like protein (MLKL) and p-MLKL] and k63-ubiquitination of RIPK3 in brain tissues. Administration of MALT1 inhibitor (Ml-2) at 8 or 15 mg/kg (i.p.) at 1 h after ischemia significantly improved neurological function and reduced infarct volume together with a downregulation of MALT1, an increase in A20 level and decreases in necroptosis-associated protein levels and k63-ubiquitination of RIPK3. Similarly, knockdown of MALT1 could also reduce oxygen-glucose deprivation/reoxygenation (OGD/R)-induced injury in the cultured HT22 cells coincident with an increase in A20 level and decreases in necroptosis-associated protein levels and k63-ubiquitination of RIPK3. Based on these observations, we conclude that MALT1 promotes necroptosis in stroke rat brain via enhancing the degradation of A20, which leads to a decrease in the capability of A20 to deubiquitinate RIPK3 at k63 and a subsequent compromise in counteraction against the brain cell necroptosis." @default.
• W4313594771 created "2023-01-06" @default.
• W4313594771 creator A5011062648 @default.
• W4313594771 creator A5020614847 @default.
• W4313594771 creator A5033428759 @default.
• W4313594771 creator A5034928000 @default.
• W4313594771 creator A5035100161 @default.
• W4313594771 creator A5048826252 @default.
• W4313594771 creator A5069733569 @default.
• W4313594771 date "2023-02-01" @default.
• W4313594771 modified "2023-09-27" @default.
• W4313594771 title "MALT1 promotes necroptosis in stroke rat brain via targeting the A20/RIPK3 pathway" @default.
• W4313594771 cites W1536074865 @default.
• W4313594771 cites W1537809359 @default.
• W4313594771 cites W1542400342 @default.
• W4313594771 cites W1554981631 @default.
• W4313594771 cites W1586634849 @default.
• W4313594771 cites W1900297117 @default.
• W4313594771 cites W1998003228 @default.
• W4313594771 cites W2060803227 @default.
• W4313594771 cites W2065434665 @default.
• W4313594771 cites W2077756009 @default.
• W4313594771 cites W2139792086 @default.
• W4313594771 cites W2144064491 @default.
• W4313594771 cites W2168758528 @default.
• W4313594771 cites W2178012989 @default.
• W4313594771 cites W2901928825 @default.
• W4313594771 cites W2904356101 @default.
• W4313594771 cites W2910248259 @default.
• W4313594771 cites W2942884587 @default.
• W4313594771 cites W2959218190 @default.
• W4313594771 cites W2977856631 @default.
• W4313594771 cites W3012190938 @default.
• W4313594771 cites W3037757547 @default.
• W4313594771 cites W3038976700 @default.
• W4313594771 cites W3127684143 @default.
• W4313594771 cites W3133452672 @default.
• W4313594771 cites W3168922957 @default.
• W4313594771 cites W3171124897 @default.
• W4313594771 cites W3183752025 @default.
• W4313594771 cites W4210774781 @default.
• W4313594771 cites W4226146004 @default.
• W4313594771 cites W3187018393 @default.
• W4313594771 doi "https://doi.org/10.1016/j.abb.2023.109502" @default.
• W4313594771 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36603698" @default.
• W4313594771 hasPublicationYear "2023" @default.
• W4313594771 type Work @default.
• W4313594771 citedByCount "1" @default.
• W4313594771 countsByYear W43135947712023 @default.
• W4313594771 crossrefType "journal-article" @default.
• W4313594771 hasAuthorship W4313594771A5011062648 @default.
• W4313594771 hasAuthorship W4313594771A5020614847 @default.
• W4313594771 hasAuthorship W4313594771A5033428759 @default.
• W4313594771 hasAuthorship W4313594771A5034928000 @default.
• W4313594771 hasAuthorship W4313594771A5035100161 @default.
• W4313594771 hasAuthorship W4313594771A5048826252 @default.
• W4313594771 hasAuthorship W4313594771A5069733569 @default.
• W4313594771 hasConcept C102658986 @default.
• W4313594771 hasConcept C104317684 @default.
• W4313594771 hasConcept C126322002 @default.
• W4313594771 hasConcept C127561419 @default.
• W4313594771 hasConcept C134459356 @default.
• W4313594771 hasConcept C173396325 @default.
• W4313594771 hasConcept C184235292 @default.
• W4313594771 hasConcept C185592680 @default.
• W4313594771 hasConcept C190283241 @default.
• W4313594771 hasConcept C25602115 @default.
• W4313594771 hasConcept C31573885 @default.
• W4313594771 hasConcept C502942594 @default.
• W4313594771 hasConcept C541997718 @default.
• W4313594771 hasConcept C55493867 @default.
• W4313594771 hasConcept C71924100 @default.
• W4313594771 hasConcept C86803240 @default.
• W4313594771 hasConcept C94030615 @default.
• W4313594771 hasConcept C95444343 @default.
• W4313594771 hasConcept C97029542 @default.
• W4313594771 hasConceptScore W4313594771C102658986 @default.
• W4313594771 hasConceptScore W4313594771C104317684 @default.
• W4313594771 hasConceptScore W4313594771C126322002 @default.
• W4313594771 hasConceptScore W4313594771C127561419 @default.
• W4313594771 hasConceptScore W4313594771C134459356 @default.
• W4313594771 hasConceptScore W4313594771C173396325 @default.
• W4313594771 hasConceptScore W4313594771C184235292 @default.
• W4313594771 hasConceptScore W4313594771C185592680 @default.
• W4313594771 hasConceptScore W4313594771C190283241 @default.
• W4313594771 hasConceptScore W4313594771C25602115 @default.
• W4313594771 hasConceptScore W4313594771C31573885 @default.
• W4313594771 hasConceptScore W4313594771C502942594 @default.
• W4313594771 hasConceptScore W4313594771C541997718 @default.
• W4313594771 hasConceptScore W4313594771C55493867 @default.
• W4313594771 hasConceptScore W4313594771C71924100 @default.
• W4313594771 hasConceptScore W4313594771C86803240 @default.
• W4313594771 hasConceptScore W4313594771C94030615 @default.
• W4313594771 hasConceptScore W4313594771C95444343 @default.
• W4313594771 hasConceptScore W4313594771C97029542 @default.
• W4313594771 hasFunder F4320321001 @default.
• W4313594771 hasLocation W43135947711 @default.
• W4313594771 hasLocation W43135947712 @default.

• next