FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313594841> ?p ?o ?g. }

• W4313594841 endingPage "101841" @default.
• W4313594841 startingPage "101841" @default.
• W4313594841 abstract "Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder in the world. Motor impairment seen in PD is associated with dopaminergic neurotoxicity in the striatum, and dopaminergic neuronal death in the substantia nigra pars compacta. Cell death has a significant effect on the development and progression of PD. Extensive research over the last few decades has unveiled new regulated cell death (RCD) mechanisms that are not dependent on apoptosis such as necroptosis, ferroptosis, and others. In this review, we will overview the mechanistic pathways of different types of RCD. Unlike accidental cell death, RCD subroutines can be regulated and the RCD-associated kinases are potential druggable targets. Hence, we will address an overview and analysis of different kinases regulating apoptosis such as receptor-interacting protein kinase 1 (RIPK-1), RIPK3, mixed lineage kinase (MLK), Ataxia telangiectasia muted (ATM), cyclin-dependent kinase (CDK), death-associated protein kinase 1 (DAPK1), Apoptosis-signaling kinase-1 (ASK-1), and Leucine-rich repeat kinase-2 (LRRK2). In addition to the role of RIPK1, RIPK3, and Mixed Lineage Kinase Domain like Pseudokinase (MLKL) in necroptosis. We also overview functions of AMP-kinase (AMPK), protein kinase C (PKC), RIPK3, and ATM in ferroptosis. We will recap the anti-apoptotic, anti-necroptotic, and anti-ferroptotic effects of different kinase inhibitors in different models of PD. Finally, we will discuss future challenges in the repositioning of kinase inhibitors in PD. In conclusion, this review kicks-start targeting RCD from a kinases perspective, opening novel therapeutic disease-modifying therapeutic avenues for PD." @default.
• W4313594841 created "2023-01-06" @default.
• W4313594841 creator A5017694931 @default.
• W4313594841 creator A5060731354 @default.
• W4313594841 creator A5073244900 @default.
• W4313594841 creator A5083261947 @default.
• W4313594841 date "2023-03-01" @default.
• W4313594841 modified "2023-10-16" @default.
• W4313594841 title "Kinases control of regulated cell death revealing druggable targets for Parkinson’s disease" @default.
• W4313594841 cites W1489699963 @default.
• W4313594841 cites W1563116834 @default.
• W4313594841 cites W1574209153 @default.
• W4313594841 cites W1744303272 @default.
• W4313594841 cites W1850224498 @default.
• W4313594841 cites W1918882820 @default.
• W4313594841 cites W1954748650 @default.
• W4313594841 cites W1966977448 @default.
• W4313594841 cites W1967178211 @default.
• W4313594841 cites W1969268163 @default.
• W4313594841 cites W1970668443 @default.
• W4313594841 cites W1971064755 @default.
• W4313594841 cites W1972320300 @default.
• W4313594841 cites W1979032223 @default.
• W4313594841 cites W1979989319 @default.
• W4313594841 cites W1984940419 @default.
• W4313594841 cites W1988487618 @default.
• W4313594841 cites W1988492326 @default.
• W4313594841 cites W1991804565 @default.
• W4313594841 cites W1993613360 @default.
• W4313594841 cites W1995038819 @default.
• W4313594841 cites W1995741673 @default.
• W4313594841 cites W1998198750 @default.
• W4313594841 cites W1998231485 @default.
• W4313594841 cites W1998983498 @default.
• W4313594841 cites W2002474940 @default.
• W4313594841 cites W2002490399 @default.
• W4313594841 cites W2002599143 @default.
• W4313594841 cites W2003241128 @default.
• W4313594841 cites W2003883601 @default.
• W4313594841 cites W2004628001 @default.
• W4313594841 cites W2007303185 @default.
• W4313594841 cites W2007751663 @default.
• W4313594841 cites W2016348267 @default.
• W4313594841 cites W2016833889 @default.
• W4313594841 cites W2025999056 @default.
• W4313594841 cites W2028044172 @default.
• W4313594841 cites W2030205108 @default.
• W4313594841 cites W2032897380 @default.
• W4313594841 cites W2033431458 @default.
• W4313594841 cites W2034006241 @default.
• W4313594841 cites W2035898183 @default.
• W4313594841 cites W2044945534 @default.
• W4313594841 cites W2045969244 @default.
• W4313594841 cites W2047890899 @default.
• W4313594841 cites W2048588387 @default.
• W4313594841 cites W2049359499 @default.
• W4313594841 cites W2052071289 @default.
• W4313594841 cites W2052605153 @default.
• W4313594841 cites W2053875448 @default.
• W4313594841 cites W2054324553 @default.
• W4313594841 cites W2055063967 @default.
• W4313594841 cites W2059315304 @default.
• W4313594841 cites W2060171156 @default.
• W4313594841 cites W2060204808 @default.
• W4313594841 cites W2060803227 @default.
• W4313594841 cites W2062880004 @default.
• W4313594841 cites W2063211255 @default.
• W4313594841 cites W2065947741 @default.
• W4313594841 cites W2066571367 @default.
• W4313594841 cites W2066610530 @default.
• W4313594841 cites W2067632426 @default.
• W4313594841 cites W2068434142 @default.
• W4313594841 cites W2070758175 @default.
• W4313594841 cites W2071201894 @default.
• W4313594841 cites W2072392477 @default.
• W4313594841 cites W2073906450 @default.
• W4313594841 cites W2074370114 @default.
• W4313594841 cites W2077317536 @default.
• W4313594841 cites W2081972226 @default.
• W4313594841 cites W2095159036 @default.
• W4313594841 cites W2100863820 @default.
• W4313594841 cites W2104965614 @default.
• W4313594841 cites W2106704279 @default.
• W4313594841 cites W2108382600 @default.
• W4313594841 cites W2110495699 @default.
• W4313594841 cites W2110796758 @default.
• W4313594841 cites W2116427780 @default.
• W4313594841 cites W2117743221 @default.
• W4313594841 cites W2119556059 @default.
• W4313594841 cites W2119683782 @default.
• W4313594841 cites W2121764638 @default.
• W4313594841 cites W2121955382 @default.
• W4313594841 cites W2122057254 @default.
• W4313594841 cites W2124681346 @default.
• W4313594841 cites W2128943563 @default.
• W4313594841 cites W2129625926 @default.
• W4313594841 cites W2130356495 @default.
• W4313594841 cites W2132161879 @default.

• next