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- W4313595284 abstract "RAS proteins regulate most aspects of cellular physiology. They are mutated in 30% of human cancers and 4% of developmental disorders termed Rasopathies. They cycle between active GTP-bound and inactive GDP-bound states. When active, they can interact with a wide range of effectors that control fundamental biochemical and biological processes. Emerging evidence suggests that RAS proteins are not simple on/off switches but sophisticated information processing devices that compute cell fate decisions by integrating external and internal cues. A critical component of this compute function is the dynamic regulation of RAS activation and downstream signaling that allows RAS to produce a rich and nuanced spectrum of biological outputs. We discuss recent findings how the dynamics of RAS and its downstream signaling is regulated. Starting from the structural and biochemical properties of wild-type and mutant RAS proteins and their activation cycle, we examine higher molecular assemblies, effector interactions and downstream signaling outputs, all under the aspect of dynamic regulation. We also consider how computational and mathematical modeling approaches contribute to analyze and understand the pleiotropic functions of RAS in health and disease." @default.
- W4313595284 created "2023-01-06" @default.
- W4313595284 creator A5036674933 @default.
- W4313595284 creator A5042865406 @default.
- W4313595284 creator A5079404524 @default.
- W4313595284 date "2023-01-06" @default.
- W4313595284 modified "2023-10-14" @default.
- W4313595284 title "Dynamic regulation of RAS and RAS signaling" @default.
- W4313595284 cites W1492513673 @default.
- W4313595284 cites W1495187352 @default.
- W4313595284 cites W1587753447 @default.
- W4313595284 cites W1774371590 @default.
- W4313595284 cites W1795056021 @default.
- W4313595284 cites W1826266252 @default.
- W4313595284 cites W1833693759 @default.
- W4313595284 cites W1916470139 @default.
- W4313595284 cites W1953264505 @default.
- W4313595284 cites W1965084174 @default.
- W4313595284 cites W1968392286 @default.
- W4313595284 cites W1969350453 @default.
- W4313595284 cites W1975186629 @default.
- W4313595284 cites W1976360756 @default.
- W4313595284 cites W1979572498 @default.
- W4313595284 cites W1980323101 @default.
- W4313595284 cites W1987195331 @default.
- W4313595284 cites W1987365716 @default.
- W4313595284 cites W1988314411 @default.
- W4313595284 cites W1992182416 @default.
- W4313595284 cites W1993620005 @default.
- W4313595284 cites W2004731962 @default.
- W4313595284 cites W2008333101 @default.
- W4313595284 cites W2008793456 @default.
- W4313595284 cites W2010955929 @default.
- W4313595284 cites W2012034410 @default.
- W4313595284 cites W2015151766 @default.
- W4313595284 cites W2018821302 @default.
- W4313595284 cites W2019556450 @default.
- W4313595284 cites W2030800389 @default.
- W4313595284 cites W2033068296 @default.
- W4313595284 cites W2036994023 @default.
- W4313595284 cites W2051728948 @default.
- W4313595284 cites W2052371969 @default.
- W4313595284 cites W2052380264 @default.
- W4313595284 cites W2057227729 @default.
- W4313595284 cites W2065909963 @default.
- W4313595284 cites W2066696278 @default.
- W4313595284 cites W2066784934 @default.
- W4313595284 cites W2068652881 @default.
- W4313595284 cites W2069800089 @default.
- W4313595284 cites W2070023258 @default.
- W4313595284 cites W2071141381 @default.
- W4313595284 cites W2075499588 @default.
- W4313595284 cites W2077452823 @default.
- W4313595284 cites W2086785381 @default.
- W4313595284 cites W2086936470 @default.
- W4313595284 cites W2086978997 @default.
- W4313595284 cites W2093486460 @default.
- W4313595284 cites W2105707485 @default.
- W4313595284 cites W2109050076 @default.
- W4313595284 cites W2123333705 @default.
- W4313595284 cites W2128339707 @default.
- W4313595284 cites W2131993341 @default.
- W4313595284 cites W2135875529 @default.
- W4313595284 cites W2154172993 @default.
- W4313595284 cites W2156078931 @default.
- W4313595284 cites W2157297563 @default.
- W4313595284 cites W2159817775 @default.
- W4313595284 cites W2162658068 @default.
- W4313595284 cites W2163430198 @default.
- W4313595284 cites W2166090806 @default.
- W4313595284 cites W2167897415 @default.
- W4313595284 cites W2168770561 @default.
- W4313595284 cites W2246817658 @default.
- W4313595284 cites W2254051095 @default.
- W4313595284 cites W2260090777 @default.
- W4313595284 cites W2271216541 @default.
- W4313595284 cites W2282990014 @default.
- W4313595284 cites W2335345046 @default.
- W4313595284 cites W2548573003 @default.
- W4313595284 cites W2566678598 @default.
- W4313595284 cites W2624203915 @default.
- W4313595284 cites W2732767128 @default.
- W4313595284 cites W2734751189 @default.
- W4313595284 cites W2735652142 @default.
- W4313595284 cites W2745326990 @default.
- W4313595284 cites W2785254688 @default.
- W4313595284 cites W2790200234 @default.
- W4313595284 cites W2793589905 @default.
- W4313595284 cites W2823044499 @default.
- W4313595284 cites W2889007489 @default.
- W4313595284 cites W2889216843 @default.
- W4313595284 cites W2890087006 @default.
- W4313595284 cites W2909177041 @default.
- W4313595284 cites W2909726024 @default.
- W4313595284 cites W2914243753 @default.
- W4313595284 cites W2917316274 @default.
- W4313595284 cites W2922210236 @default.
- W4313595284 cites W2926958318 @default.