Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313595522> ?p ?o ?g. }
- W4313595522 abstract "Amyloid light-chain (AL) amyloidosis is a rare disease characterized by amyloid fibril deposits made up of toxic light chains causing progressive organ dysfunction and death. Recent studies suggest that hematologic response may be an important prognostic indicator of overall survival (OS) in AL amyloidosis. The aim of this study was to evaluate the trial-level association between hematologic complete response (CR) or very good partial response or better (≥ VGPR) and OS in newly diagnosed patients.Studies were identified via systematic literature review. Pooled effect estimates were generated by a random-effects model.Nine observational studies reporting hematologic CR or ≥VGPR and OS hazard ratios (HRs) were included in the meta-analysis. Achieving hematologic CR was associated with improved OS (HR, 0.21; 95% confidence interval [CI] 0.13-0.34). Achieving ≥ VGPR was also associated with improved OS (HR 0.21; 95% CI 0.17-0.26). Results of a sensitivity analysis excluding one outlier study revealed no heterogeneity and a better overall HR estimate. Potential limitations of this meta-analysis include the small number of eligible studies (consistent with the rarity of the disease) and inconsistencies in reporting of results.Overall, our findings support the use of deep hematologic response (CR or ≥VGPR) as a clinical trial endpoint in newly diagnosed AL amyloidosis. This study provides evidence that early hematologic response is a strong patient-level surrogate for long-term OS in patients with AL amyloidosis receiving frontline therapy. Structured data collection of depth of response in future trials will further strengthen these observations." @default.
- W4313595522 created "2023-01-06" @default.
- W4313595522 creator A5018522443 @default.
- W4313595522 creator A5036262237 @default.
- W4313595522 creator A5053469869 @default.
- W4313595522 creator A5054329532 @default.
- W4313595522 creator A5060990365 @default.
- W4313595522 creator A5070082694 @default.
- W4313595522 creator A5084737431 @default.
- W4313595522 creator A5085549618 @default.
- W4313595522 creator A5087364145 @default.
- W4313595522 creator A5089945534 @default.
- W4313595522 date "2023-01-06" @default.
- W4313595522 modified "2023-09-27" @default.
- W4313595522 title "Assessing the prognostic utility of hematologic response for overall survival in patients with newly diagnosed AL amyloidosis: results of a meta-analysis" @default.
- W4313595522 cites W1567835982 @default.
- W4313595522 cites W1956430368 @default.
- W4313595522 cites W1969551915 @default.
- W4313595522 cites W1982967337 @default.
- W4313595522 cites W2003181078 @default.
- W4313595522 cites W2033793452 @default.
- W4313595522 cites W2044266840 @default.
- W4313595522 cites W2052710970 @default.
- W4313595522 cites W2108158641 @default.
- W4313595522 cites W2111080788 @default.
- W4313595522 cites W2115902267 @default.
- W4313595522 cites W2119605658 @default.
- W4313595522 cites W2121886547 @default.
- W4313595522 cites W2126930838 @default.
- W4313595522 cites W2128536827 @default.
- W4313595522 cites W2129528847 @default.
- W4313595522 cites W2157823046 @default.
- W4313595522 cites W2158206316 @default.
- W4313595522 cites W2166659565 @default.
- W4313595522 cites W2169767242 @default.
- W4313595522 cites W2200389714 @default.
- W4313595522 cites W2217385909 @default.
- W4313595522 cites W2330120407 @default.
- W4313595522 cites W2414653379 @default.
- W4313595522 cites W2781851390 @default.
- W4313595522 cites W2808935221 @default.
- W4313595522 cites W2898144881 @default.
- W4313595522 cites W2930190144 @default.
- W4313595522 cites W3034340360 @default.
- W4313595522 cites W3036329541 @default.
- W4313595522 cites W3046046238 @default.
- W4313595522 cites W3048889268 @default.
- W4313595522 cites W3082294855 @default.
- W4313595522 cites W3085262612 @default.
- W4313595522 cites W3097250203 @default.
- W4313595522 cites W3097577984 @default.
- W4313595522 cites W3173370182 @default.
- W4313595522 cites W3174070807 @default.
- W4313595522 cites W3175638404 @default.
- W4313595522 cites W4200173454 @default.
- W4313595522 cites W4212770753 @default.
- W4313595522 doi "https://doi.org/10.1080/16078454.2022.2157581" @default.
- W4313595522 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36607151" @default.
- W4313595522 hasPublicationYear "2023" @default.
- W4313595522 type Work @default.
- W4313595522 citedByCount "1" @default.
- W4313595522 countsByYear W43135955222023 @default.
- W4313595522 crossrefType "journal-article" @default.
- W4313595522 hasAuthorship W4313595522A5018522443 @default.
- W4313595522 hasAuthorship W4313595522A5036262237 @default.
- W4313595522 hasAuthorship W4313595522A5053469869 @default.
- W4313595522 hasAuthorship W4313595522A5054329532 @default.
- W4313595522 hasAuthorship W4313595522A5060990365 @default.
- W4313595522 hasAuthorship W4313595522A5070082694 @default.
- W4313595522 hasAuthorship W4313595522A5084737431 @default.
- W4313595522 hasAuthorship W4313595522A5085549618 @default.
- W4313595522 hasAuthorship W4313595522A5087364145 @default.
- W4313595522 hasAuthorship W4313595522A5089945534 @default.
- W4313595522 hasBestOaLocation W43135955221 @default.
- W4313595522 hasConcept C126322002 @default.
- W4313595522 hasConcept C143998085 @default.
- W4313595522 hasConcept C159654299 @default.
- W4313595522 hasConcept C168743327 @default.
- W4313595522 hasConcept C203014093 @default.
- W4313595522 hasConcept C207103383 @default.
- W4313595522 hasConcept C23131810 @default.
- W4313595522 hasConcept C2779551797 @default.
- W4313595522 hasConcept C2779951007 @default.
- W4313595522 hasConcept C36394416 @default.
- W4313595522 hasConcept C44249647 @default.
- W4313595522 hasConcept C535046627 @default.
- W4313595522 hasConcept C71924100 @default.
- W4313595522 hasConcept C95190672 @default.
- W4313595522 hasConceptScore W4313595522C126322002 @default.
- W4313595522 hasConceptScore W4313595522C143998085 @default.
- W4313595522 hasConceptScore W4313595522C159654299 @default.
- W4313595522 hasConceptScore W4313595522C168743327 @default.
- W4313595522 hasConceptScore W4313595522C203014093 @default.
- W4313595522 hasConceptScore W4313595522C207103383 @default.
- W4313595522 hasConceptScore W4313595522C23131810 @default.
- W4313595522 hasConceptScore W4313595522C2779551797 @default.
- W4313595522 hasConceptScore W4313595522C2779951007 @default.
- W4313595522 hasConceptScore W4313595522C36394416 @default.
- W4313595522 hasConceptScore W4313595522C44249647 @default.
- W4313595522 hasConceptScore W4313595522C535046627 @default.