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• W4313595725 abstract "Introduction: Rodent models of cardiovascular disease have uncovered various types of lymphatic vessel dysfunction that occur in association with atherosclerosis, type II diabetes and obesity. Previously, we presented in vivo evidence for impaired lymphatic drainage in apolipoprotein E null ( ApoE −/− ) mice fed a high fat diet (HFD). Whether this impairment relates to the dysfunction of collecting lymphatics remains an open question. The ApoE −/− mouse is a well-established model of cardiovascular disease, in which a diet rich in fat and cholesterol on an ApoE deficient background accelerates the development of hypercholesteremia, atherosclerotic plaques and inflammation of the skin and other tissues. Here, we investigated various aspects of lymphatic function using ex vivo tests of collecting lymphatic vessels from ApoE +/+ or ApoE −/− mice fed a HFD. Methods: Popliteal collectors were excised from either strain and studied under defined conditions in which we could quantify changes in lymphatic contractile strength, lymph pump output, secondary valve function, and collecting vessel permeability. Results: Our results show that all these aspects of lymphatic vessel function are altered in deleterious ways in this model of hypercholesterolemia. Discussion: These findings extend previous in vivo observations suggesting significant dysfunction of lymphatic endothelial cells and smooth muscle cells from collecting vessels in association with a HFD on an ApoE -deficient background. An implication of our study is that collecting vessel dysfunction in this context may negatively impact the removal of cholesterol by the lymphatic system from the skin and the arterial wall and thereby exacerbate the progression and/or severity of atherosclerosis and associated inflammation." @default.
• W4313595725 created "2023-01-06" @default.
• W4313595725 creator A5004395527 @default.
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• W4313595725 date "2023-01-06" @default.
• W4313595725 modified "2023-10-05" @default.
• W4313595725 title "Multiple aspects of lymphatic dysfunction in an ApoE−/− mouse model of hypercholesterolemia" @default.
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• W4313595725 doi "https://doi.org/10.3389/fphys.2022.1098408" @default.
• W4313595725 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36685213" @default.
• W4313595725 hasPublicationYear "2023" @default.
• W4313595725 type Work @default.
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• W4313595725 hasAuthorship W4313595725A5004395527 @default.
• W4313595725 hasAuthorship W4313595725A5012876307 @default.

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