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• W4313595860 abstract "This article addresses the problem of identifying the maximum tolerated dose (MTD) in Phase I dose-finding clinical trials with late-onset toxicities. The main design challenge is how best to adaptively allocate study participants to tolerable doses when the evaluation window for the toxicity endpoint is long relative to the accrual rate of new participants. We propose a new design framework based on order-restricted statistical inference that addresses this challenge in sequential dose assignments. We illustrate the proposed method on real data from a Phase I trial of bortezomib in lymphoma patients and apply it to a Phase I trial of radiotherapy in prostate cancer patients. We conduct extensive simulation studies to compare our design’s operating characteristics to existing published methods. Overall, our proposed design demonstrates good performance relative to existing methods in allocating participants at and around the MTD during the study and accurately recommending the MTD at the study conclusion." @default.
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• W4313595860 date "2023-01-06" @default.
• W4313595860 modified "2023-09-27" @default.
• W4313595860 title "Isotonic design for phase I cancer clinical trials with late-onset toxicities" @default.
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• W4313595860 doi "https://doi.org/10.1080/10543406.2022.2162068" @default.
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