FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313596410> ?p ?o ?g. }

• W4313596410 endingPage "108135" @default.
• W4313596410 startingPage "108135" @default.
• W4313596410 abstract "Engineering small-molecule drugs into nanoparticulate formulations provides an unprecedented opportunity to improve the performance of traditional chemo drugs, but suffers from poor compatibility between drugs and nanocarriers. Stimuli-responsive mPEG-PDLLA–drug conjugate-based nanomedicines can facilitate the exploitation of beneficial properties of the carrier and enable the practical fabrication of highly efficacious self-assembled nanomedicines. However, the influence of hydrophobic length on the performance of this type of nanomedicine is little known. Here we synthesized two acid-sensitive ketal-linked mPEG-PDLLA–docetaxel prodrugs with different lengths of PDLLA, and engineered them into self-assembled sub-20 nm micellar nanomedicines for breast cancer chemotherapy. We found that the nanomedicine consisting of a mPEG-PDLLA–docetaxel prodrug with the shorter length of PDLLA stood out due to its potent cytotoxicity, deep penetration into multicellular spheroids, and improved in vivo anticancer performance. Additionally, our prodrug-based nanomedicines outperformed the generic formulation of commercial Nanoxel in terms of safety profile, tolerated doses, and tumor suppression. Our findings indicate that the hydrophobic content of a polymeric prodrug nanomedicine plays an important role in the performance of the nanomedicine, and should be instructive for developing polymeric prodrug-based nanomedicines with clinical translational potential." @default.
• W4313596410 created "2023-01-06" @default.
• W4313596410 creator A5006824735 @default.
• W4313596410 creator A5013297039 @default.
• W4313596410 creator A5017354560 @default.
• W4313596410 creator A5031070620 @default.
• W4313596410 creator A5031150615 @default.
• W4313596410 creator A5031259910 @default.
• W4313596410 creator A5038766727 @default.
• W4313596410 creator A5052769199 @default.
• W4313596410 creator A5053323525 @default.
• W4313596410 creator A5070538645 @default.
• W4313596410 date "2023-09-01" @default.
• W4313596410 modified "2023-10-14" @default.
• W4313596410 title "PDLLA length on anti-breast cancer efficacy of acid-responsive self-assembling mPEG-PDLLA‒docetaxel conjugates" @default.
• W4313596410 cites W1975088956 @default.
• W4313596410 cites W2003741425 @default.
• W4313596410 cites W2016920512 @default.
• W4313596410 cites W2020398834 @default.
• W4313596410 cites W2055483349 @default.
• W4313596410 cites W2062071298 @default.
• W4313596410 cites W2069016591 @default.
• W4313596410 cites W2083710155 @default.
• W4313596410 cites W2087012160 @default.
• W4313596410 cites W2091010508 @default.
• W4313596410 cites W2101312385 @default.
• W4313596410 cites W2135486162 @default.
• W4313596410 cites W2278083835 @default.
• W4313596410 cites W2342130560 @default.
• W4313596410 cites W2409322723 @default.
• W4313596410 cites W2554773181 @default.
• W4313596410 cites W2734856592 @default.
• W4313596410 cites W2889302258 @default.
• W4313596410 cites W2904389476 @default.
• W4313596410 cites W2984284890 @default.
• W4313596410 cites W2990441762 @default.
• W4313596410 cites W3000289898 @default.
• W4313596410 cites W3088981963 @default.
• W4313596410 cites W3112897634 @default.
• W4313596410 cites W3201391064 @default.
• W4313596410 cites W809125785 @default.
• W4313596410 doi "https://doi.org/10.1016/j.cclet.2023.108135" @default.
• W4313596410 hasPublicationYear "2023" @default.
• W4313596410 type Work @default.
• W4313596410 citedByCount "0" @default.
• W4313596410 crossrefType "journal-article" @default.
• W4313596410 hasAuthorship W4313596410A5006824735 @default.
• W4313596410 hasAuthorship W4313596410A5013297039 @default.
• W4313596410 hasAuthorship W4313596410A5017354560 @default.
• W4313596410 hasAuthorship W4313596410A5031070620 @default.
• W4313596410 hasAuthorship W4313596410A5031150615 @default.
• W4313596410 hasAuthorship W4313596410A5031259910 @default.
• W4313596410 hasAuthorship W4313596410A5038766727 @default.
• W4313596410 hasAuthorship W4313596410A5052769199 @default.
• W4313596410 hasAuthorship W4313596410A5053323525 @default.
• W4313596410 hasAuthorship W4313596410A5070538645 @default.
• W4313596410 hasBestOaLocation W43135964101 @default.
• W4313596410 hasConcept C108215921 @default.
• W4313596410 hasConcept C109316439 @default.
• W4313596410 hasConcept C121608353 @default.
• W4313596410 hasConcept C126322002 @default.
• W4313596410 hasConcept C134306372 @default.
• W4313596410 hasConcept C15083742 @default.
• W4313596410 hasConcept C155672457 @default.
• W4313596410 hasConcept C171250308 @default.
• W4313596410 hasConcept C18150654 @default.
• W4313596410 hasConcept C185592680 @default.
• W4313596410 hasConcept C192562407 @default.
• W4313596410 hasConcept C197336794 @default.
• W4313596410 hasConcept C202751555 @default.
• W4313596410 hasConcept C2781190966 @default.
• W4313596410 hasConcept C33923547 @default.
• W4313596410 hasConcept C55493867 @default.
• W4313596410 hasConcept C71924100 @default.
• W4313596410 hasConcept C98274493 @default.
• W4313596410 hasConceptScore W4313596410C108215921 @default.
• W4313596410 hasConceptScore W4313596410C109316439 @default.
• W4313596410 hasConceptScore W4313596410C121608353 @default.
• W4313596410 hasConceptScore W4313596410C126322002 @default.
• W4313596410 hasConceptScore W4313596410C134306372 @default.
• W4313596410 hasConceptScore W4313596410C15083742 @default.
• W4313596410 hasConceptScore W4313596410C155672457 @default.
• W4313596410 hasConceptScore W4313596410C171250308 @default.
• W4313596410 hasConceptScore W4313596410C18150654 @default.
• W4313596410 hasConceptScore W4313596410C185592680 @default.
• W4313596410 hasConceptScore W4313596410C192562407 @default.
• W4313596410 hasConceptScore W4313596410C197336794 @default.
• W4313596410 hasConceptScore W4313596410C202751555 @default.
• W4313596410 hasConceptScore W4313596410C2781190966 @default.
• W4313596410 hasConceptScore W4313596410C33923547 @default.
• W4313596410 hasConceptScore W4313596410C55493867 @default.
• W4313596410 hasConceptScore W4313596410C71924100 @default.
• W4313596410 hasConceptScore W4313596410C98274493 @default.
• W4313596410 hasFunder F4320321001 @default.
• W4313596410 hasFunder F4320321543 @default.
• W4313596410 hasFunder F4320323993 @default.
• W4313596410 hasIssue "9" @default.
• W4313596410 hasLocation W43135964101 @default.

• next