Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313596500> ?p ?o ?g. }
- W4313596500 endingPage "108689" @default.
- W4313596500 startingPage "108689" @default.
- W4313596500 abstract "Of all the human body's sensory systems, the auditory system is perhaps its most intricate. Hearing loss can result from even modest damage or cell death in the inner ear, and is the most common form of sensory loss. Human hearing is made possible by the sensory epithelium, the lateral wall, and auditory nerves. The most prominent functional cells in the sensory epithelium are outer hair cells (OHCs), inner hair cells (IHCs), and supporting cells. Different sound frequencies are processed by OHCs and IHCs in different cochlear regions, with those in the apex responsible for low frequencies and those in the basal region responsible for high frequencies. Hair cells can be damaged or destroyed by loud noise, aging process, genetic mutations, ototoxicity, infection, and illness. As such, they are a primary target for treating sensorineural hearing loss. Other areas known to affect hearing include spiral ganglion neurons (SGNs) in the auditory nerve. Age-related degradation of HCs and SGNs can also cause hearing loss. The aim of this review is to introduce the roles of mitochondria in human auditory system and the inner ear's main cell types and cellular functions, before going on to detail the likely health benefits of iPSC technology. We posit that patient-specific iPSCs with mitochondrial gene mutations will be an important aspect of regenerative medicine and will lead to significant progress in the treatment of SNHL." @default.
- W4313596500 created "2023-01-06" @default.
- W4313596500 creator A5010134972 @default.
- W4313596500 creator A5070106135 @default.
- W4313596500 date "2023-03-01" @default.
- W4313596500 modified "2023-10-13" @default.
- W4313596500 title "Current development of patient-specific induced pluripotent stem cells harbouring mitochondrial gene mutations and their applications in the treatment of sensorineural hearing loss" @default.
- W4313596500 cites W1122557064 @default.
- W4313596500 cites W1493480907 @default.
- W4313596500 cites W1575008411 @default.
- W4313596500 cites W1787354152 @default.
- W4313596500 cites W1974420229 @default.
- W4313596500 cites W1977545536 @default.
- W4313596500 cites W1984818415 @default.
- W4313596500 cites W1996067374 @default.
- W4313596500 cites W1997200985 @default.
- W4313596500 cites W1999321816 @default.
- W4313596500 cites W1999481607 @default.
- W4313596500 cites W2001699589 @default.
- W4313596500 cites W2002151981 @default.
- W4313596500 cites W2002595078 @default.
- W4313596500 cites W2003863108 @default.
- W4313596500 cites W2007551053 @default.
- W4313596500 cites W2020768773 @default.
- W4313596500 cites W2050880536 @default.
- W4313596500 cites W2052406996 @default.
- W4313596500 cites W2053247751 @default.
- W4313596500 cites W2067091330 @default.
- W4313596500 cites W2069726499 @default.
- W4313596500 cites W2071963951 @default.
- W4313596500 cites W2079226610 @default.
- W4313596500 cites W2080795364 @default.
- W4313596500 cites W2085025210 @default.
- W4313596500 cites W2090620992 @default.
- W4313596500 cites W2098401829 @default.
- W4313596500 cites W2101649826 @default.
- W4313596500 cites W2110054223 @default.
- W4313596500 cites W2138261854 @default.
- W4313596500 cites W2138317563 @default.
- W4313596500 cites W2138428458 @default.
- W4313596500 cites W2159603999 @default.
- W4313596500 cites W2162903822 @default.
- W4313596500 cites W2262076248 @default.
- W4313596500 cites W2263734165 @default.
- W4313596500 cites W2284220652 @default.
- W4313596500 cites W2307783424 @default.
- W4313596500 cites W2313711585 @default.
- W4313596500 cites W2518455343 @default.
- W4313596500 cites W2571421343 @default.
- W4313596500 cites W2599397208 @default.
- W4313596500 cites W2610506730 @default.
- W4313596500 cites W2626395940 @default.
- W4313596500 cites W2751618406 @default.
- W4313596500 cites W2759791820 @default.
- W4313596500 cites W2768088906 @default.
- W4313596500 cites W2778564871 @default.
- W4313596500 cites W2793238502 @default.
- W4313596500 cites W2793552792 @default.
- W4313596500 cites W2799724133 @default.
- W4313596500 cites W2801247820 @default.
- W4313596500 cites W2805046580 @default.
- W4313596500 cites W2850195675 @default.
- W4313596500 cites W2883287048 @default.
- W4313596500 cites W2892032098 @default.
- W4313596500 cites W2895267799 @default.
- W4313596500 cites W2915594963 @default.
- W4313596500 cites W2918382948 @default.
- W4313596500 cites W2922101506 @default.
- W4313596500 cites W2924297061 @default.
- W4313596500 cites W2933485012 @default.
- W4313596500 cites W2942799604 @default.
- W4313596500 cites W2945984140 @default.
- W4313596500 cites W2951454612 @default.
- W4313596500 cites W2964038138 @default.
- W4313596500 cites W2995272570 @default.
- W4313596500 cites W3011956003 @default.
- W4313596500 cites W3022343660 @default.
- W4313596500 cites W3041877641 @default.
- W4313596500 cites W3046727590 @default.
- W4313596500 cites W3071487942 @default.
- W4313596500 cites W3081636038 @default.
- W4313596500 cites W3092964179 @default.
- W4313596500 cites W3108261929 @default.
- W4313596500 cites W3157689224 @default.
- W4313596500 cites W3165652155 @default.
- W4313596500 cites W3172313421 @default.
- W4313596500 cites W3205393868 @default.
- W4313596500 cites W3216939983 @default.
- W4313596500 cites W4200266695 @default.
- W4313596500 cites W4206497105 @default.
- W4313596500 cites W4210874460 @default.
- W4313596500 cites W4220947307 @default.
- W4313596500 cites W4220969111 @default.
- W4313596500 cites W4224880055 @default.
- W4313596500 cites W4249448382 @default.
- W4313596500 cites W4280561832 @default.
- W4313596500 cites W4280623644 @default.
- W4313596500 cites W4285093930 @default.