Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313596544> ?p ?o ?g. }
- W4313596544 endingPage "122320" @default.
- W4313596544 startingPage "122320" @default.
- W4313596544 abstract "Recently, the number of structural modifications of synthetic cathinones has been growing making them the second largest group of new psychoactive substances in Europe. Although they are abused because of their various psychoactive effects, some compounds from this group also serve as pharmaceuticals. Since synthetic cathinones are chiral molecules with one chiral center, their biological, toxicological, and pharmacological properties may significantly differ according to their absolute configuration and enantiomeric excess. In this study, we have synthesized two substances bearing a pharmacologically interesting trifluoromethyl group and developed a chiral liquid chromatography method using a polysaccharide chiral stationary phase to separate the corresponding enantiomers of both these drugs. Subsequently, we utilized molecular spectroscopic methods including chiroptical (electronic circular dichroism and vibrational circular dichroism) and non-polarizable (infrared and ultraviolet absorption) spectroscopies. In combination with density functional theory calculations, we have obtained stable conformers of selected enantiomers in solution and their relative abundances, which we used to simulate their spectra. The experimental and calculated data have been used to elucidate the 3D structure of the enantiomerically pure compounds and assign the absolute configuration of all prepared compounds." @default.
- W4313596544 created "2023-01-06" @default.
- W4313596544 creator A5018454669 @default.
- W4313596544 creator A5040921208 @default.
- W4313596544 creator A5045978174 @default.
- W4313596544 creator A5049329681 @default.
- W4313596544 creator A5050603964 @default.
- W4313596544 creator A5057306173 @default.
- W4313596544 creator A5068024184 @default.
- W4313596544 creator A5069714246 @default.
- W4313596544 creator A5084865612 @default.
- W4313596544 creator A5089230793 @default.
- W4313596544 date "2023-04-01" @default.
- W4313596544 modified "2023-10-14" @default.
- W4313596544 title "Enantioseparation and a comprehensive spectroscopic analysis of novel synthetic cathinones laterally substituted with a trifluoromethyl group" @default.
- W4313596544 cites W1572907996 @default.
- W4313596544 cites W1942355674 @default.
- W4313596544 cites W1977213360 @default.
- W4313596544 cites W1982118979 @default.
- W4313596544 cites W1993401088 @default.
- W4313596544 cites W2032821512 @default.
- W4313596544 cites W2045620394 @default.
- W4313596544 cites W2049151031 @default.
- W4313596544 cites W2054676094 @default.
- W4313596544 cites W2064440181 @default.
- W4313596544 cites W2065206569 @default.
- W4313596544 cites W2080294650 @default.
- W4313596544 cites W2085342352 @default.
- W4313596544 cites W2089089883 @default.
- W4313596544 cites W2098859456 @default.
- W4313596544 cites W2099336264 @default.
- W4313596544 cites W2111276034 @default.
- W4313596544 cites W2120610043 @default.
- W4313596544 cites W2142308666 @default.
- W4313596544 cites W2145899862 @default.
- W4313596544 cites W2155898167 @default.
- W4313596544 cites W2157382250 @default.
- W4313596544 cites W2164867125 @default.
- W4313596544 cites W2184917803 @default.
- W4313596544 cites W2213806195 @default.
- W4313596544 cites W2333845812 @default.
- W4313596544 cites W2344605273 @default.
- W4313596544 cites W2409722113 @default.
- W4313596544 cites W2411630047 @default.
- W4313596544 cites W2463574483 @default.
- W4313596544 cites W2509082481 @default.
- W4313596544 cites W2509562474 @default.
- W4313596544 cites W2534067489 @default.
- W4313596544 cites W2564586557 @default.
- W4313596544 cites W2778221373 @default.
- W4313596544 cites W2791545636 @default.
- W4313596544 cites W2794568316 @default.
- W4313596544 cites W2804071209 @default.
- W4313596544 cites W2899190363 @default.
- W4313596544 cites W2919767908 @default.
- W4313596544 cites W2946700363 @default.
- W4313596544 cites W2947669261 @default.
- W4313596544 cites W2951283070 @default.
- W4313596544 cites W3000113877 @default.
- W4313596544 cites W3003240411 @default.
- W4313596544 cites W3033234908 @default.
- W4313596544 cites W3094844043 @default.
- W4313596544 cites W3109748527 @default.
- W4313596544 cites W3112971518 @default.
- W4313596544 cites W4223507714 @default.
- W4313596544 doi "https://doi.org/10.1016/j.saa.2023.122320" @default.
- W4313596544 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36634495" @default.
- W4313596544 hasPublicationYear "2023" @default.
- W4313596544 type Work @default.
- W4313596544 citedByCount "0" @default.
- W4313596544 crossrefType "journal-article" @default.
- W4313596544 hasAuthorship W4313596544A5018454669 @default.
- W4313596544 hasAuthorship W4313596544A5040921208 @default.
- W4313596544 hasAuthorship W4313596544A5045978174 @default.
- W4313596544 hasAuthorship W4313596544A5049329681 @default.
- W4313596544 hasAuthorship W4313596544A5050603964 @default.
- W4313596544 hasAuthorship W4313596544A5057306173 @default.
- W4313596544 hasAuthorship W4313596544A5068024184 @default.
- W4313596544 hasAuthorship W4313596544A5069714246 @default.
- W4313596544 hasAuthorship W4313596544A5084865612 @default.
- W4313596544 hasAuthorship W4313596544A5089230793 @default.
- W4313596544 hasConcept C121332964 @default.
- W4313596544 hasConcept C124668440 @default.
- W4313596544 hasConcept C133571119 @default.
- W4313596544 hasConcept C139287275 @default.
- W4313596544 hasConcept C147597530 @default.
- W4313596544 hasConcept C16838498 @default.
- W4313596544 hasConcept C178790620 @default.
- W4313596544 hasConcept C185592680 @default.
- W4313596544 hasConcept C18705241 @default.
- W4313596544 hasConcept C189010761 @default.
- W4313596544 hasConcept C20621625 @default.
- W4313596544 hasConcept C25170562 @default.
- W4313596544 hasConcept C32909587 @default.
- W4313596544 hasConcept C486523 @default.
- W4313596544 hasConcept C52703039 @default.
- W4313596544 hasConcept C62520636 @default.
- W4313596544 hasConcept C71240020 @default.