FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313596918> ?p ?o ?g. }

• W4313596918 abstract "Abstract The inhibition of tumor necrosis factor-α (TNFα) trimer formation renders it inactive for binding to its receptors thus mitigating the vicious cycle of inflammation. We designed a peptide (PIYLGGVFQ) that simulates a sequence strand of human TNFα monomer using a series of in silico methods, such as active site finding (Acsite), protein-protein interaction (PPI), docking studies (GOLD and Modeller) followed by molecular dynamics (MD) simulation studies. The MD studies confirmed the intermolecular interaction of the peptide with the TNFα. Fluorescence-activated cell sorting (FACS) and fluorescence microscopy revealed that the peptide effectively inhibited the binding of TNF to the cell surface receptors. The cell culture assays showed that the peptide significantly inhibited the TNFα-mediated cell death. In addition, the nuclear translocation of the nuclear factor kappa B (NFκB) was significantly suppressed in the peptide-treated A549 cells as observed in immunofluorescence and gelmobility-shift assays. Furthermore, peptide protected against joint damage in collagen-induced arthritis (CIA)mouse model as revealed in the microfocal-CT scans. In conclusion, this TNFα antagonist would be useful for the prevention and repair ofinflammatory bone destruction and subsequent loss in the mouse model of CIA as well as human rheumatoid arthritis (RA) patients. This calls upon further clinical investigation to utilize its potential effect as an anti-arthritic drug." @default.
• W4313596918 created "2023-01-06" @default.
• W4313596918 creator A5000257153 @default.
• W4313596918 creator A5001569945 @default.
• W4313596918 creator A5001744435 @default.
• W4313596918 creator A5011070454 @default.
• W4313596918 creator A5015783767 @default.
• W4313596918 creator A5020820734 @default.
• W4313596918 creator A5021065960 @default.
• W4313596918 creator A5025500452 @default.
• W4313596918 creator A5036546811 @default.
• W4313596918 creator A5039402267 @default.
• W4313596918 creator A5043443002 @default.
• W4313596918 creator A5044827974 @default.
• W4313596918 creator A5067893495 @default.
• W4313596918 creator A5087302432 @default.
• W4313596918 date "2023-01-06" @default.
• W4313596918 modified "2023-10-16" @default.
• W4313596918 title "Novel Peptide Inhibitor of Human Tumor Necrosis Factor-α has Antiarthritic Activity" @default.
• W4313596918 cites W1501675811 @default.
• W4313596918 cites W1968608249 @default.
• W4313596918 cites W1973191530 @default.
• W4313596918 cites W1978349280 @default.
• W4313596918 cites W1996794055 @default.
• W4313596918 cites W2012542956 @default.
• W4313596918 cites W2029667189 @default.
• W4313596918 cites W2036528355 @default.
• W4313596918 cites W2053301460 @default.
• W4313596918 cites W2060079863 @default.
• W4313596918 cites W2066142272 @default.
• W4313596918 cites W2081912151 @default.
• W4313596918 cites W2115075530 @default.
• W4313596918 cites W2128332459 @default.
• W4313596918 cites W2132933661 @default.
• W4313596918 cites W2133401156 @default.
• W4313596918 cites W2161605421 @default.
• W4313596918 cites W2415138561 @default.
• W4313596918 cites W2586156612 @default.
• W4313596918 cites W2586574625 @default.
• W4313596918 cites W2964379090 @default.
• W4313596918 cites W3007300164 @default.
• W4313596918 cites W3120153401 @default.
• W4313596918 cites W4221077556 @default.
• W4313596918 doi "https://doi.org/10.21203/rs.3.rs-2429424/v1" @default.
• W4313596918 hasPublicationYear "2023" @default.
• W4313596918 type Work @default.
• W4313596918 citedByCount "0" @default.
• W4313596918 crossrefType "posted-content" @default.
• W4313596918 hasAuthorship W4313596918A5000257153 @default.
• W4313596918 hasAuthorship W4313596918A5001569945 @default.
• W4313596918 hasAuthorship W4313596918A5001744435 @default.
• W4313596918 hasAuthorship W4313596918A5011070454 @default.
• W4313596918 hasAuthorship W4313596918A5015783767 @default.
• W4313596918 hasAuthorship W4313596918A5020820734 @default.
• W4313596918 hasAuthorship W4313596918A5021065960 @default.
• W4313596918 hasAuthorship W4313596918A5025500452 @default.
• W4313596918 hasAuthorship W4313596918A5036546811 @default.
• W4313596918 hasAuthorship W4313596918A5039402267 @default.
• W4313596918 hasAuthorship W4313596918A5043443002 @default.
• W4313596918 hasAuthorship W4313596918A5044827974 @default.
• W4313596918 hasAuthorship W4313596918A5067893495 @default.
• W4313596918 hasAuthorship W4313596918A5087302432 @default.
• W4313596918 hasBestOaLocation W43135969181 @default.
• W4313596918 hasConcept C104317684 @default.
• W4313596918 hasConcept C153911025 @default.
• W4313596918 hasConcept C170493617 @default.
• W4313596918 hasConcept C17991360 @default.
• W4313596918 hasConcept C185592680 @default.
• W4313596918 hasConcept C203014093 @default.
• W4313596918 hasConcept C2775905019 @default.
• W4313596918 hasConcept C2777077863 @default.
• W4313596918 hasConcept C2779281246 @default.
• W4313596918 hasConcept C55493867 @default.
• W4313596918 hasConcept C86803240 @default.
• W4313596918 hasConcept C95444343 @default.
• W4313596918 hasConceptScore W4313596918C104317684 @default.
• W4313596918 hasConceptScore W4313596918C153911025 @default.
• W4313596918 hasConceptScore W4313596918C170493617 @default.
• W4313596918 hasConceptScore W4313596918C17991360 @default.
• W4313596918 hasConceptScore W4313596918C185592680 @default.
• W4313596918 hasConceptScore W4313596918C203014093 @default.
• W4313596918 hasConceptScore W4313596918C2775905019 @default.
• W4313596918 hasConceptScore W4313596918C2777077863 @default.
• W4313596918 hasConceptScore W4313596918C2779281246 @default.
• W4313596918 hasConceptScore W4313596918C55493867 @default.
• W4313596918 hasConceptScore W4313596918C86803240 @default.
• W4313596918 hasConceptScore W4313596918C95444343 @default.
• W4313596918 hasLocation W43135969181 @default.
• W4313596918 hasLocation W43135969182 @default.
• W4313596918 hasOpenAccess W4313596918 @default.
• W4313596918 hasPrimaryLocation W43135969181 @default.
• W4313596918 hasRelatedWork W1772299322 @default.
• W4313596918 hasRelatedWork W2053169479 @default.
• W4313596918 hasRelatedWork W2068103783 @default.
• W4313596918 hasRelatedWork W3106184723 @default.
• W4313596918 hasRelatedWork W3197618792 @default.
• W4313596918 hasRelatedWork W4200516109 @default.
• W4313596918 hasRelatedWork W4236574014 @default.
• W4313596918 hasRelatedWork W4301395162 @default.
• W4313596918 hasRelatedWork W756474329 @default.

• next