Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313597170> ?p ?o ?g. }
- W4313597170 abstract "The incidence of androgen alopecia (AGA), also known as seborrheic alopecia, has surged in recent years, and onset is occurring at younger ages. Dermal papilla cells (DPCs) are key to maintaining hair cycling, and apoptosis-driven processes in DPCs are closely related to hair follicle regeneration. Circular RNAs (circRNAs) are widely present in the human body and are closely related to the occurrence and development of many diseases. Currently, the biological functions of circRNAs in AGA are largely unknown. Whole-transcriptome sequencing was used to screen differential circRNA expression profiles between AGA patients and non-AGA patients. We found that hsa_circ_0002980 (circAGK) was significantly highly expressed in the AGA group. CircAGK promoted DPC apoptosis in the presence of high dihydrotestosterone (DHT) (15 nmol/L). By regulating the miR-3180-5p/BAX axis, circAGK promotes DPC apoptosis in a high DHT environment in vitro and inhibits hair growth in AGA mice in vivo, indicating that circAGK is a potential target for the clinical treatment of AGA." @default.
- W4313597170 created "2023-01-06" @default.
- W4313597170 creator A5022256556 @default.
- W4313597170 creator A5035210583 @default.
- W4313597170 creator A5051251648 @default.
- W4313597170 creator A5054804415 @default.
- W4313597170 creator A5069771802 @default.
- W4313597170 creator A5071464019 @default.
- W4313597170 creator A5072289684 @default.
- W4313597170 creator A5075631882 @default.
- W4313597170 creator A5085688374 @default.
- W4313597170 date "2023-01-06" @default.
- W4313597170 modified "2023-10-14" @default.
- W4313597170 title "<scp>CircAGK</scp> regulates high dihydrotestosterone‐induced apoptosis in <scp>DPCs</scp> through the <scp>miR‐3180‐5p/BAX</scp> axis" @default.
- W4313597170 cites W2028048630 @default.
- W4313597170 cites W2510155593 @default.
- W4313597170 cites W2625836171 @default.
- W4313597170 cites W2803717982 @default.
- W4313597170 cites W2808978509 @default.
- W4313597170 cites W2892630678 @default.
- W4313597170 cites W2934451614 @default.
- W4313597170 cites W2945544594 @default.
- W4313597170 cites W2949359703 @default.
- W4313597170 cites W2964331590 @default.
- W4313597170 cites W2998586985 @default.
- W4313597170 cites W3006182545 @default.
- W4313597170 cites W3096132241 @default.
- W4313597170 cites W3107138019 @default.
- W4313597170 cites W3110806949 @default.
- W4313597170 cites W3110968116 @default.
- W4313597170 cites W3124966978 @default.
- W4313597170 cites W3129039058 @default.
- W4313597170 cites W3130536487 @default.
- W4313597170 cites W3131256500 @default.
- W4313597170 cites W3133844941 @default.
- W4313597170 cites W3135849798 @default.
- W4313597170 cites W3136588013 @default.
- W4313597170 cites W3146221315 @default.
- W4313597170 cites W3191752584 @default.
- W4313597170 cites W3197715143 @default.
- W4313597170 cites W3202532355 @default.
- W4313597170 cites W3212759142 @default.
- W4313597170 cites W3217805296 @default.
- W4313597170 cites W4206389311 @default.
- W4313597170 cites W4210776227 @default.
- W4313597170 cites W4213125844 @default.
- W4313597170 cites W4220763878 @default.
- W4313597170 doi "https://doi.org/10.1096/fj.202200849r" @default.
- W4313597170 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36607259" @default.
- W4313597170 hasPublicationYear "2023" @default.
- W4313597170 type Work @default.
- W4313597170 citedByCount "1" @default.
- W4313597170 countsByYear W43135971702023 @default.
- W4313597170 crossrefType "journal-article" @default.
- W4313597170 hasAuthorship W4313597170A5022256556 @default.
- W4313597170 hasAuthorship W4313597170A5035210583 @default.
- W4313597170 hasAuthorship W4313597170A5051251648 @default.
- W4313597170 hasAuthorship W4313597170A5054804415 @default.
- W4313597170 hasAuthorship W4313597170A5069771802 @default.
- W4313597170 hasAuthorship W4313597170A5071464019 @default.
- W4313597170 hasAuthorship W4313597170A5072289684 @default.
- W4313597170 hasAuthorship W4313597170A5075631882 @default.
- W4313597170 hasAuthorship W4313597170A5085688374 @default.
- W4313597170 hasConcept C104317684 @default.
- W4313597170 hasConcept C121608353 @default.
- W4313597170 hasConcept C126322002 @default.
- W4313597170 hasConcept C134018914 @default.
- W4313597170 hasConcept C150194340 @default.
- W4313597170 hasConcept C162317418 @default.
- W4313597170 hasConcept C185592680 @default.
- W4313597170 hasConcept C190283241 @default.
- W4313597170 hasConcept C202751555 @default.
- W4313597170 hasConcept C207001950 @default.
- W4313597170 hasConcept C2777216303 @default.
- W4313597170 hasConcept C2777911890 @default.
- W4313597170 hasConcept C2779279991 @default.
- W4313597170 hasConcept C2779881493 @default.
- W4313597170 hasConcept C2780192828 @default.
- W4313597170 hasConcept C502942594 @default.
- W4313597170 hasConcept C54355233 @default.
- W4313597170 hasConcept C55493867 @default.
- W4313597170 hasConcept C61367390 @default.
- W4313597170 hasConcept C71315377 @default.
- W4313597170 hasConcept C71924100 @default.
- W4313597170 hasConcept C86803240 @default.
- W4313597170 hasConcept C95444343 @default.
- W4313597170 hasConceptScore W4313597170C104317684 @default.
- W4313597170 hasConceptScore W4313597170C121608353 @default.
- W4313597170 hasConceptScore W4313597170C126322002 @default.
- W4313597170 hasConceptScore W4313597170C134018914 @default.
- W4313597170 hasConceptScore W4313597170C150194340 @default.
- W4313597170 hasConceptScore W4313597170C162317418 @default.
- W4313597170 hasConceptScore W4313597170C185592680 @default.
- W4313597170 hasConceptScore W4313597170C190283241 @default.
- W4313597170 hasConceptScore W4313597170C202751555 @default.
- W4313597170 hasConceptScore W4313597170C207001950 @default.
- W4313597170 hasConceptScore W4313597170C2777216303 @default.
- W4313597170 hasConceptScore W4313597170C2777911890 @default.
- W4313597170 hasConceptScore W4313597170C2779279991 @default.
- W4313597170 hasConceptScore W4313597170C2779881493 @default.