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- W4313597601 abstract "As a rare immune-mediated adverse reaction to immune checkpoint inhibitor (ICI) therapy, immune checkpoint inhibitor associated renal-limited thrombotic microangiopathy (ICI-rTMA) is a biopsy-proven kidney-limited TMA without the classical triad of systemic TMA. With the expanding use of ICIs, reports of ICI-rTMA are limited yet emerging. ICI-rTMA currently has a poor renal prognosis and a lack of treatment strategy. Furthermore, ICI re-challenge poses a difficult clinical dilemma wherein renal function must be maintained without risking the higher mortality associated with ICI withdrawal. This review summarizes six reported cases of ICI-rTMA and discusses the current literature on ICI-rTMA regarding its potential mechanisms of pathogenesis, the vital role of kidney biopsy in diagnosis, treatment options, and the dilemma surrounding ICI re-challenge." @default.
- W4313597601 created "2023-01-06" @default.
- W4313597601 creator A5044490023 @default.
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- W4313597601 date "2023-01-04" @default.
- W4313597601 modified "2023-10-17" @default.
- W4313597601 title "A brief review of renal-limited thrombotic microangiopathy associated with immune checkpoint inhibitors" @default.
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- W4313597601 doi "https://doi.org/10.1177/23993693221147769" @default.
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