Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313597677> ?p ?o ?g. }
- W4313597677 endingPage "191" @default.
- W4313597677 startingPage "187" @default.
- W4313597677 abstract "Numerous malignancies, including colorectal and liver cancers, are ultimately more likely to occur in obese people, and chronic inflammatory conditions have been linked to this association. We are attempting to determine the clinical relevance of the mechanisms controlling the microRNA (miR-215 and miR-146a) expression and transforming growth factor-β (TGF-β)/interleukin-6 (IL-6) in a cross-link axis between obesity and colorectal cancer (CRC). Study participants were divided into four groups: healthy controls; obese without colorectal cancer; non-obese colorectal cancer; and obese with colorectal cancer. Obese and CRC patients had markedly higher expression of IL-6 and TGF-β, as well as tumor biomarkers, such as carcinoembryonic antigen (CEA), carbohydrate antigen 19.9 (CA19.9), and alpha-fetoprotein (AFP) levels. The relative expression of microRNAs (miR-215 and miR-146a) was significantly lower in obese patients with colorectal cancer. BMI and the microRNAs(miR-215 and miR-146a) showed a substantial negative correlation. TGF-β was favorably linked with IL-6, cholesterol, triglyceride levels, and BMI. High levels of TGF-β and IL-6 in the blood indicate how intensely inflammation develops in obesity, which could increase the risk of colorectal cancer." @default.
- W4313597677 created "2023-01-06" @default.
- W4313597677 creator A5018108920 @default.
- W4313597677 creator A5040939130 @default.
- W4313597677 creator A5056425658 @default.
- W4313597677 creator A5057750988 @default.
- W4313597677 creator A5063556110 @default.
- W4313597677 date "2023-06-01" @default.
- W4313597677 modified "2023-10-01" @default.
- W4313597677 title "Signature of micro RNA 146a/215 and IL-6/TGF-β levels in a cross-link axis between obesity and colorectal cancer" @default.
- W4313597677 cites W1544853383 @default.
- W4313597677 cites W1978327452 @default.
- W4313597677 cites W2012997103 @default.
- W4313597677 cites W2024859904 @default.
- W4313597677 cites W2039431935 @default.
- W4313597677 cites W2048520349 @default.
- W4313597677 cites W2069136947 @default.
- W4313597677 cites W2097233439 @default.
- W4313597677 cites W2107277218 @default.
- W4313597677 cites W2148658155 @default.
- W4313597677 cites W2175623018 @default.
- W4313597677 cites W2192080449 @default.
- W4313597677 cites W2238354465 @default.
- W4313597677 cites W2261067062 @default.
- W4313597677 cites W2311593232 @default.
- W4313597677 cites W2313405898 @default.
- W4313597677 cites W2418709497 @default.
- W4313597677 cites W2567264284 @default.
- W4313597677 cites W2574998181 @default.
- W4313597677 cites W2586162100 @default.
- W4313597677 cites W2607734543 @default.
- W4313597677 cites W2757901891 @default.
- W4313597677 cites W2766565054 @default.
- W4313597677 cites W2769490473 @default.
- W4313597677 cites W2890778790 @default.
- W4313597677 cites W2907317928 @default.
- W4313597677 cites W2914482945 @default.
- W4313597677 cites W2916952753 @default.
- W4313597677 cites W2944549000 @default.
- W4313597677 cites W2975595653 @default.
- W4313597677 cites W2989842006 @default.
- W4313597677 cites W3010962314 @default.
- W4313597677 cites W3035424174 @default.
- W4313597677 cites W3041171573 @default.
- W4313597677 cites W3081156381 @default.
- W4313597677 cites W3124577077 @default.
- W4313597677 cites W3128044426 @default.
- W4313597677 cites W3128301585 @default.
- W4313597677 cites W3163366541 @default.
- W4313597677 cites W3167994896 @default.
- W4313597677 cites W4205226221 @default.
- W4313597677 cites W4214887802 @default.
- W4313597677 cites W4280634995 @default.
- W4313597677 cites W4289704973 @default.
- W4313597677 cites W4290729304 @default.
- W4313597677 doi "https://doi.org/10.1016/j.ncrna.2023.01.001" @default.
- W4313597677 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36710985" @default.
- W4313597677 hasPublicationYear "2023" @default.
- W4313597677 type Work @default.
- W4313597677 citedByCount "5" @default.
- W4313597677 countsByYear W43135976772023 @default.
- W4313597677 crossrefType "journal-article" @default.
- W4313597677 hasAuthorship W4313597677A5018108920 @default.
- W4313597677 hasAuthorship W4313597677A5040939130 @default.
- W4313597677 hasAuthorship W4313597677A5056425658 @default.
- W4313597677 hasAuthorship W4313597677A5057750988 @default.
- W4313597677 hasAuthorship W4313597677A5063556110 @default.
- W4313597677 hasBestOaLocation W43135976771 @default.
- W4313597677 hasConcept C104317684 @default.
- W4313597677 hasConcept C118131993 @default.
- W4313597677 hasConcept C121608353 @default.
- W4313597677 hasConcept C126322002 @default.
- W4313597677 hasConcept C143998085 @default.
- W4313597677 hasConcept C145059251 @default.
- W4313597677 hasConcept C2777387746 @default.
- W4313597677 hasConcept C2778163477 @default.
- W4313597677 hasConcept C2778913445 @default.
- W4313597677 hasConcept C511355011 @default.
- W4313597677 hasConcept C526805850 @default.
- W4313597677 hasConcept C55493867 @default.
- W4313597677 hasConcept C71924100 @default.
- W4313597677 hasConcept C86803240 @default.
- W4313597677 hasConceptScore W4313597677C104317684 @default.
- W4313597677 hasConceptScore W4313597677C118131993 @default.
- W4313597677 hasConceptScore W4313597677C121608353 @default.
- W4313597677 hasConceptScore W4313597677C126322002 @default.
- W4313597677 hasConceptScore W4313597677C143998085 @default.
- W4313597677 hasConceptScore W4313597677C145059251 @default.
- W4313597677 hasConceptScore W4313597677C2777387746 @default.
- W4313597677 hasConceptScore W4313597677C2778163477 @default.
- W4313597677 hasConceptScore W4313597677C2778913445 @default.
- W4313597677 hasConceptScore W4313597677C511355011 @default.
- W4313597677 hasConceptScore W4313597677C526805850 @default.
- W4313597677 hasConceptScore W4313597677C55493867 @default.
- W4313597677 hasConceptScore W4313597677C71924100 @default.
- W4313597677 hasConceptScore W4313597677C86803240 @default.
- W4313597677 hasIssue "2" @default.
- W4313597677 hasLocation W43135976771 @default.