Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313597905> ?p ?o ?g. }
- W4313597905 endingPage "213283" @default.
- W4313597905 startingPage "213283" @default.
- W4313597905 abstract "As an organizer of multi-molecular membrane complexes, the tetraspanin CD9 has been implicated in a number of biological processes, including cancer metastasis, and is a candidate therapeutic target. Here, we evaluated the suppressive effects of an eight-mer CD9-binding peptide (CD9-BP) on cancer cell metastasis and its mechanisms of action. CD9-BP impaired CD9-related functions by adversely affecting the formation of tetraspanin webs—networks composed of CD9 and its partner proteins. The anti-cancer metastasis effect of CD9-BP was evidenced by the in vitro inhibition of cancer cell migration and invasion as well as exosome secretion and uptake, which are essential processes during metastasis. Finally, using a mouse model, we showed that CD9-BP reduced lung metastasis in vivo. These findings provide insight into the mechanism by which CD9-BP inhibits CD9-dependent functions and highlight its potential application as an alternative therapeutic nano-biomaterial for metastatic cancers." @default.
- W4313597905 created "2023-01-06" @default.
- W4313597905 creator A5004608361 @default.
- W4313597905 creator A5018575134 @default.
- W4313597905 creator A5036955721 @default.
- W4313597905 creator A5038627694 @default.
- W4313597905 creator A5058589470 @default.
- W4313597905 creator A5083277387 @default.
- W4313597905 creator A5084959889 @default.
- W4313597905 creator A5086313652 @default.
- W4313597905 date "2023-03-01" @default.
- W4313597905 modified "2023-09-27" @default.
- W4313597905 title "A peptide binding to the tetraspanin CD9 reduces cancer metastasis" @default.
- W4313597905 cites W1426045486 @default.
- W4313597905 cites W1950118853 @default.
- W4313597905 cites W1967427925 @default.
- W4313597905 cites W1984885025 @default.
- W4313597905 cites W1996960280 @default.
- W4313597905 cites W2012129117 @default.
- W4313597905 cites W2013885862 @default.
- W4313597905 cites W2028006609 @default.
- W4313597905 cites W2059743653 @default.
- W4313597905 cites W2063186096 @default.
- W4313597905 cites W2078286807 @default.
- W4313597905 cites W2087645253 @default.
- W4313597905 cites W2105299356 @default.
- W4313597905 cites W2118829058 @default.
- W4313597905 cites W2146743474 @default.
- W4313597905 cites W2163169267 @default.
- W4313597905 cites W2739638175 @default.
- W4313597905 cites W2800787044 @default.
- W4313597905 cites W2803823272 @default.
- W4313597905 cites W2809729525 @default.
- W4313597905 cites W2891310923 @default.
- W4313597905 cites W2902384546 @default.
- W4313597905 cites W2940308113 @default.
- W4313597905 cites W2963020634 @default.
- W4313597905 cites W2967213355 @default.
- W4313597905 cites W2969777750 @default.
- W4313597905 cites W3008684461 @default.
- W4313597905 cites W3012307045 @default.
- W4313597905 cites W3013481845 @default.
- W4313597905 cites W3013529030 @default.
- W4313597905 cites W3016058897 @default.
- W4313597905 cites W3041206783 @default.
- W4313597905 cites W3048596299 @default.
- W4313597905 cites W3080227974 @default.
- W4313597905 cites W3108005369 @default.
- W4313597905 cites W3114142903 @default.
- W4313597905 cites W3129738147 @default.
- W4313597905 cites W3153335067 @default.
- W4313597905 cites W3156005845 @default.
- W4313597905 cites W4205957462 @default.
- W4313597905 cites W4211263609 @default.
- W4313597905 cites W4224879895 @default.
- W4313597905 doi "https://doi.org/10.1016/j.bioadv.2023.213283" @default.
- W4313597905 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36640525" @default.
- W4313597905 hasPublicationYear "2023" @default.
- W4313597905 type Work @default.
- W4313597905 citedByCount "3" @default.
- W4313597905 countsByYear W43135979052023 @default.
- W4313597905 crossrefType "journal-article" @default.
- W4313597905 hasAuthorship W4313597905A5004608361 @default.
- W4313597905 hasAuthorship W4313597905A5018575134 @default.
- W4313597905 hasAuthorship W4313597905A5036955721 @default.
- W4313597905 hasAuthorship W4313597905A5038627694 @default.
- W4313597905 hasAuthorship W4313597905A5058589470 @default.
- W4313597905 hasAuthorship W4313597905A5083277387 @default.
- W4313597905 hasAuthorship W4313597905A5084959889 @default.
- W4313597905 hasAuthorship W4313597905A5086313652 @default.
- W4313597905 hasConcept C121608353 @default.
- W4313597905 hasConcept C1491633281 @default.
- W4313597905 hasConcept C150903083 @default.
- W4313597905 hasConcept C207001950 @default.
- W4313597905 hasConcept C2777208748 @default.
- W4313597905 hasConcept C2779013556 @default.
- W4313597905 hasConcept C2992691968 @default.
- W4313597905 hasConcept C502942594 @default.
- W4313597905 hasConcept C54355233 @default.
- W4313597905 hasConcept C55493867 @default.
- W4313597905 hasConcept C86803240 @default.
- W4313597905 hasConcept C96232424 @default.
- W4313597905 hasConceptScore W4313597905C121608353 @default.
- W4313597905 hasConceptScore W4313597905C1491633281 @default.
- W4313597905 hasConceptScore W4313597905C150903083 @default.
- W4313597905 hasConceptScore W4313597905C207001950 @default.
- W4313597905 hasConceptScore W4313597905C2777208748 @default.
- W4313597905 hasConceptScore W4313597905C2779013556 @default.
- W4313597905 hasConceptScore W4313597905C2992691968 @default.
- W4313597905 hasConceptScore W4313597905C502942594 @default.
- W4313597905 hasConceptScore W4313597905C54355233 @default.
- W4313597905 hasConceptScore W4313597905C55493867 @default.
- W4313597905 hasConceptScore W4313597905C86803240 @default.
- W4313597905 hasConceptScore W4313597905C96232424 @default.
- W4313597905 hasLocation W43135979051 @default.
- W4313597905 hasLocation W43135979052 @default.
- W4313597905 hasOpenAccess W4313597905 @default.
- W4313597905 hasPrimaryLocation W43135979051 @default.