Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313597924> ?p ?o ?g. }
- W4313597924 endingPage "103322" @default.
- W4313597924 startingPage "103322" @default.
- W4313597924 abstract "Degeneration of the serotonin system has been observed in Alzheimer's disease (AD) and in mild cognitive impairment (MCI). In transgenic amyloid mouse models, serotonin degeneration is detected prior to widespread cortical beta-amyloid (Aβ) deposition, also suggesting that serotonin degeneration may be observed in preclinical AD.The differences in the distribution of serotonin degeneration (reflected by the loss of the serotonin transporter, 5-HTT) relative to Aβ deposition was measured with positron emission tomography in a group of individuals with MCI and a group of healthy older adults. A multi-modal partial least squares (mmPLS) algorithm was applied to identify the spatial covariance pattern between 5-HTT availability and Aβ deposition.Forty-five individuals with MCI and 35 healthy older adults were studied, 22 and 27 of whom were included in the analyses who were amyloid positive and amyloid negative, respectively. A pattern of lower cortical, subcortical and limbic 5-HTT availability and higher cortical Aβ deposition distinguished the MCI from the healthy older control participants. Greater expression of this pattern was correlated with greater deficits in memory and executive function in the MCI group, not in the control group.A spatial covariance pattern of lower 5-HTT availability and Aβ deposition was observed to a greater extent in an MCI group relative to a control group and was associated with cognitive impairment in the MCI group. The results support the application of mmPLS to understand the neurochemical changes associated with Aβ deposition in the course of preclinical AD." @default.
- W4313597924 created "2023-01-06" @default.
- W4313597924 creator A5004794322 @default.
- W4313597924 creator A5004835193 @default.
- W4313597924 creator A5007203242 @default.
- W4313597924 creator A5009306474 @default.
- W4313597924 creator A5011936420 @default.
- W4313597924 creator A5021803422 @default.
- W4313597924 creator A5027820710 @default.
- W4313597924 creator A5034770106 @default.
- W4313597924 creator A5047768726 @default.
- W4313597924 creator A5052076205 @default.
- W4313597924 creator A5059930129 @default.
- W4313597924 creator A5064352152 @default.
- W4313597924 creator A5079953860 @default.
- W4313597924 creator A5082107467 @default.
- W4313597924 date "2023-01-01" @default.
- W4313597924 modified "2023-10-14" @default.
- W4313597924 title "Molecular imaging of the association between serotonin degeneration and beta-amyloid deposition in mild cognitive impairment" @default.
- W4313597924 cites W137926846 @default.
- W4313597924 cites W1494065222 @default.
- W4313597924 cites W1565624092 @default.
- W4313597924 cites W1747781838 @default.
- W4313597924 cites W1847168837 @default.
- W4313597924 cites W1964595024 @default.
- W4313597924 cites W1972324473 @default.
- W4313597924 cites W1974875055 @default.
- W4313597924 cites W1976452134 @default.
- W4313597924 cites W1983565638 @default.
- W4313597924 cites W1990439642 @default.
- W4313597924 cites W1999169358 @default.
- W4313597924 cites W1999330418 @default.
- W4313597924 cites W2003428745 @default.
- W4313597924 cites W2004293194 @default.
- W4313597924 cites W2004564253 @default.
- W4313597924 cites W2006962925 @default.
- W4313597924 cites W2010754688 @default.
- W4313597924 cites W2013999515 @default.
- W4313597924 cites W2014070897 @default.
- W4313597924 cites W2023121717 @default.
- W4313597924 cites W2023586735 @default.
- W4313597924 cites W2030773481 @default.
- W4313597924 cites W2031368339 @default.
- W4313597924 cites W2035299293 @default.
- W4313597924 cites W2042676032 @default.
- W4313597924 cites W2048790339 @default.
- W4313597924 cites W2050591554 @default.
- W4313597924 cites W2051508159 @default.
- W4313597924 cites W2051541361 @default.
- W4313597924 cites W2053051596 @default.
- W4313597924 cites W2054929374 @default.
- W4313597924 cites W2056716542 @default.
- W4313597924 cites W2056970740 @default.
- W4313597924 cites W2057888342 @default.
- W4313597924 cites W2058046532 @default.
- W4313597924 cites W2059083799 @default.
- W4313597924 cites W2063808031 @default.
- W4313597924 cites W2063897123 @default.
- W4313597924 cites W2065189628 @default.
- W4313597924 cites W2068760847 @default.
- W4313597924 cites W2071804866 @default.
- W4313597924 cites W2072371192 @default.
- W4313597924 cites W2072525935 @default.
- W4313597924 cites W2073094854 @default.
- W4313597924 cites W2074224911 @default.
- W4313597924 cites W2074909493 @default.
- W4313597924 cites W2076147201 @default.
- W4313597924 cites W2077338272 @default.
- W4313597924 cites W2078909485 @default.
- W4313597924 cites W2079852568 @default.
- W4313597924 cites W2089542831 @default.
- W4313597924 cites W2090663050 @default.
- W4313597924 cites W2091869534 @default.
- W4313597924 cites W2101135654 @default.
- W4313597924 cites W2107013935 @default.
- W4313597924 cites W2111581233 @default.
- W4313597924 cites W2111963393 @default.
- W4313597924 cites W2114092053 @default.
- W4313597924 cites W2114613490 @default.
- W4313597924 cites W2124879385 @default.
- W4313597924 cites W2125658585 @default.
- W4313597924 cites W2129951633 @default.
- W4313597924 cites W2130668599 @default.
- W4313597924 cites W2133719476 @default.
- W4313597924 cites W2152038045 @default.
- W4313597924 cites W2152446053 @default.
- W4313597924 cites W2155298532 @default.
- W4313597924 cites W2165475353 @default.
- W4313597924 cites W2167062215 @default.
- W4313597924 cites W2167720733 @default.
- W4313597924 cites W2169346955 @default.
- W4313597924 cites W2174753847 @default.
- W4313597924 cites W2177509216 @default.
- W4313597924 cites W2307936244 @default.
- W4313597924 cites W2353776455 @default.
- W4313597924 cites W2432513713 @default.
- W4313597924 cites W2600623181 @default.
- W4313597924 cites W2614013403 @default.