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• W4313598078 abstract "Responses of the indigenous human gut commensal microbiota to iron are poorly understood because of an emphasis on in vitro studies of pathogen iron sensitivity. In a study of iron supplementation in healthy humans, we identified gradual microbiota shifts in some participants correlated with bacterial iron internalization. To identify direct effects due to taxon-specific iron sensitivity, we used participant stool samples to derive diverse in vitro communities. Iron supplementation of these communities caused small compositional shifts, mimicking those in vivo, whereas iron deprivation dramatically inhibited growth with irreversible, cumulative reduction in diversity and replacement of dominant species. Sensitivity of individual species to iron deprivation in axenic culture generally predicted iron dependency in a community. Finally, exogenous heme acted as a source of inorganic iron to prevent depletion of some species. Our results highlight the complementarity of in vivo and in vitro studies in understanding how environmental factors affect gut microbiotas." @default.
• W4313598078 created "2023-01-06" @default.
• W4313598078 creator A5006484941 @default.
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• W4313598078 date "2023-01-01" @default.
• W4313598078 modified "2023-09-23" @default.
• W4313598078 title "The impact of iron and heme availability on the healthy human gut microbiome in vivo and in vitro" @default.
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• W4313598078 doi "https://doi.org/10.1016/j.chembiol.2022.12.001" @default.
• W4313598078 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36603582" @default.
• W4313598078 hasPublicationYear "2023" @default.
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