Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313622517> ?p ?o ?g. }
- W4313622517 endingPage "990" @default.
- W4313622517 startingPage "979" @default.
- W4313622517 abstract "The rational design of lipid nanoparticles (LNPs) for enhanced gene delivery remains challenging because of incomplete knowledge of their formulation-structure relationship that impacts their intracellular behavior and consequent function. Small-angle neutron scattering has been used in this work to investigate the structure of LNPs encapsulating plasmid DNA upon their acidification (from pH 7.4 to 4.0), as would be encountered during endocytosis. The results revealed the acidification-induced structure evolution (AISE) of the LNPs on different dimension scales, involving protonation of the ionizable lipid, volume expansion and redistribution of aqueous and lipid components. A similarity analysis using an LNP's structural feature space showed a strong positive correlation between function (measured by intracellular luciferase expression) and the extent of AISE, which was further enhanced by the fraction of unsaturated helper lipid. Our findings reveal molecular and nanoscale changes occurring during AISE that underpin the LNPs' formulation-nanostructure-function relationship, aiding the rational design of application-directed gene delivery vehicles." @default.
- W4313622517 created "2023-01-07" @default.
- W4313622517 creator A5005601404 @default.
- W4313622517 creator A5030131037 @default.
- W4313622517 creator A5033240222 @default.
- W4313622517 creator A5063509219 @default.
- W4313622517 creator A5066402294 @default.
- W4313622517 creator A5074225402 @default.
- W4313622517 creator A5075864247 @default.
- W4313622517 creator A5090366404 @default.
- W4313622517 date "2023-01-06" @default.
- W4313622517 modified "2023-10-14" @default.
- W4313622517 title "Acidification-Induced Structure Evolution of Lipid Nanoparticles Correlates with Their <i>In Vitro</i> Gene Transfections" @default.
- W4313622517 cites W1957140265 @default.
- W4313622517 cites W1966334833 @default.
- W4313622517 cites W1971741270 @default.
- W4313622517 cites W1995636745 @default.
- W4313622517 cites W2007445917 @default.
- W4313622517 cites W2007767060 @default.
- W4313622517 cites W2009642901 @default.
- W4313622517 cites W2029397995 @default.
- W4313622517 cites W2030124972 @default.
- W4313622517 cites W2039551908 @default.
- W4313622517 cites W2045101135 @default.
- W4313622517 cites W2049854598 @default.
- W4313622517 cites W2057402777 @default.
- W4313622517 cites W2066061512 @default.
- W4313622517 cites W2069374586 @default.
- W4313622517 cites W2071463077 @default.
- W4313622517 cites W2083249633 @default.
- W4313622517 cites W2092770422 @default.
- W4313622517 cites W2095151181 @default.
- W4313622517 cites W2106885643 @default.
- W4313622517 cites W2119939433 @default.
- W4313622517 cites W2125470506 @default.
- W4313622517 cites W2153771870 @default.
- W4313622517 cites W2157979200 @default.
- W4313622517 cites W2208560199 @default.
- W4313622517 cites W2287068442 @default.
- W4313622517 cites W2313640741 @default.
- W4313622517 cites W2323505647 @default.
- W4313622517 cites W2521078391 @default.
- W4313622517 cites W2526010095 @default.
- W4313622517 cites W2557562124 @default.
- W4313622517 cites W2566902031 @default.
- W4313622517 cites W2583831774 @default.
- W4313622517 cites W2606251873 @default.
- W4313622517 cites W2647579821 @default.
- W4313622517 cites W2770097561 @default.
- W4313622517 cites W2784187371 @default.
- W4313622517 cites W2794867971 @default.
- W4313622517 cites W2795918326 @default.
- W4313622517 cites W2801179771 @default.
- W4313622517 cites W2914060533 @default.
- W4313622517 cites W2941514458 @default.
- W4313622517 cites W2975259971 @default.
- W4313622517 cites W2992823069 @default.
- W4313622517 cites W3006764150 @default.
- W4313622517 cites W3021028979 @default.
- W4313622517 cites W3047091198 @default.
- W4313622517 cites W3093367571 @default.
- W4313622517 cites W3097847842 @default.
- W4313622517 cites W3099052308 @default.
- W4313622517 cites W3128860426 @default.
- W4313622517 cites W3137338783 @default.
- W4313622517 cites W3139111210 @default.
- W4313622517 cites W3148255637 @default.
- W4313622517 cites W3176970273 @default.
- W4313622517 cites W3188940990 @default.
- W4313622517 cites W3205093280 @default.
- W4313622517 cites W3213910483 @default.
- W4313622517 cites W4200171779 @default.
- W4313622517 cites W4206715271 @default.
- W4313622517 cites W87784013 @default.
- W4313622517 doi "https://doi.org/10.1021/acsnano.2c06213" @default.
- W4313622517 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36608273" @default.
- W4313622517 hasPublicationYear "2023" @default.
- W4313622517 type Work @default.
- W4313622517 citedByCount "4" @default.
- W4313622517 countsByYear W43136225172023 @default.
- W4313622517 crossrefType "journal-article" @default.
- W4313622517 hasAuthorship W4313622517A5005601404 @default.
- W4313622517 hasAuthorship W4313622517A5030131037 @default.
- W4313622517 hasAuthorship W4313622517A5033240222 @default.
- W4313622517 hasAuthorship W4313622517A5063509219 @default.
- W4313622517 hasAuthorship W4313622517A5066402294 @default.
- W4313622517 hasAuthorship W4313622517A5074225402 @default.
- W4313622517 hasAuthorship W4313622517A5075864247 @default.
- W4313622517 hasAuthorship W4313622517A5090366404 @default.
- W4313622517 hasBestOaLocation W43136225171 @default.
- W4313622517 hasConcept C104317684 @default.
- W4313622517 hasConcept C12554922 @default.
- W4313622517 hasConcept C135983454 @default.
- W4313622517 hasConcept C1491633281 @default.
- W4313622517 hasConcept C155672457 @default.
- W4313622517 hasConcept C171250308 @default.
- W4313622517 hasConcept C185592680 @default.
- W4313622517 hasConcept C192562407 @default.