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• W4313622599 abstract "Background and purpose Acute aortic dissection (AAD) is a life-threatening cardiovascular emergency. Both neutrophil granzyme and interleukin (IL)-33/ST2 systems have proven to be effective diagnostic markers for AAD. This study aimed to investigate the relationship between plasma IL-33, soluble suppression of tumorigenesis-2 (sST2), myeloperoxidase (MPO), and matrix metalloproteinase (MMP)-9 levels at admission and all-cause mortality in patients with AAD. Methods A total of 155 patients with AAD were enrolled from the Prospective Evaluation of Acute Chest Pain (PEACP) study. Plasma concentrations of IL-33, sST2, and MMP-9 were measured using an enzyme-linked immunosorbent assay, and MPO was detected using a chemiluminescence immunoassay. Aortic anatomical parameters were measured using CT radiography. The primary endpoint was all-cause mortality rate. Results The median age of the patients was 55 years, and 96 (61.9%) were diagnosed with type A-AAD. After adjusting for confounding factors, the highest tertiles of IL-33, sST2, MPO, and MMP-9 had hazard risks of 0.870 (95% CI: 0.412–1.836, P = 0.714), 3.769 (95% CI: 1.504–9.446, P = 0.005), 4.689 (95% CI: 1.985–11.076, P &lt; 0.001), and 4.748 (95% CI: 1.763–12.784, P = 0.002), respectively, compared to the lowest tertile. Pearson’s correlation analysis revealed a significant correlation between these markers ( P &lt; 0.001). Moreover, sST2, MPO, and MMP-9 levels had a significant positive correlation with aortic diameter and pseudolumen area ( P &lt; 0.001). Conclusion The biomarkers sST2, MPO, and MMP-9 were independently associated with mortality in patients with AAD. The significant correlation between these biomarkers suggests a pathogenic role for the IL-33/ST2/neutrophil granzyme system in patients with AAD." @default.
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• W4313622599 date "2023-01-06" @default.
• W4313622599 modified "2023-10-18" @default.
• W4313622599 title "Prognostic value of interleukin-33, sST2, myeloperoxidase, and matrix metalloproteinase-9 in acute aortic dissection" @default.
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• W4313622599 doi "https://doi.org/10.3389/fcvm.2022.1084321" @default.
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