FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313625065> ?p ?o ?g. }

• W4313625065 endingPage "e32613" @default.
• W4313625065 startingPage "e32613" @default.
• W4313625065 abstract "Background: Pioglitazone is currently used as an anti-diabetic agent and can reduce cardiovascular events in in patients with type 2 diabetes mellitus (T2DM). Left ventricular diastolic dysfunction has been recognized as an early manifestation of myocardial dysfunction in T2DM patients. This systematic review and meta-analysis aimed to investigate changes in the left ventricular diastolic function after the treatment of pioglitazone. Methods: A systematic literature search of PubMed, Embase, and the Cochrane Library until May 2021 with keywords pioglitazone and left ventricular diastolic function was performed in accordance with the meta-analysis of observational studies in epidemiology guidelines and preferred reporting items for systematic reviews and meta-analyses statement. Three reviewers independently selected the studies and extracted data. Quality assessment of the included studies was undergone. A fixed effects model was used to calculate overall effect sizes. Subgroup analyses were subsequently performed. A fixed effects model was used to calculate the overall effect size. Subgroup analyses were then performed. Results: Seven studies with 233 patients were investigated. We found pioglitazone significantly improved hemoglobin A1c (%) in patients with T2DM and left ventricular diastolic function had an improvement tendency (weighted mean difference [WMD], 0.03; 95% confidence interval [CI], 0.01–0.05, P < .01) despite moderate heterogeneity ( I 2 = 66%). Subsequent subgroup analysis indicated that left ventricular diastolic function were significantly improved (WMD, 0.20; 95% CI, 0.12–0.29, P < .001) in T2DM patients whose average age < 55 after receiving pioglitazone treatment. However, in T2DM patients with mean age ≥ 55 years, there was no significant improvement of left ventricular diastolic function (WMD, 0.02; 95% CI, 0–0.04, P = .04). Conclusion: Pioglitazone treatment significantly improved left ventricular diastolic function in type 2 diabetic patients with a mean age of < 55 years, but did not improve left ventricular diastolic function in patients with a mean age of ≥ 55 years." @default.
• W4313625065 created "2023-01-07" @default.
• W4313625065 creator A5028719956 @default.
• W4313625065 creator A5031957558 @default.
• W4313625065 creator A5058197133 @default.
• W4313625065 creator A5061284364 @default.
• W4313625065 creator A5073525543 @default.
• W4313625065 date "2023-01-06" @default.
• W4313625065 modified "2023-10-14" @default.
• W4313625065 title "Change in left ventricular diastolic function after pioglitazone treatment in patients with type 2 diabetes mellitus: A protocol for systematic review and meta-analysis" @default.
• W4313625065 cites W1538441117 @default.
• W4313625065 cites W1963542379 @default.
• W4313625065 cites W1966292746 @default.
• W4313625065 cites W1976143502 @default.
• W4313625065 cites W1979423827 @default.
• W4313625065 cites W1985503665 @default.
• W4313625065 cites W1991775164 @default.
• W4313625065 cites W2092644531 @default.
• W4313625065 cites W2101667913 @default.
• W4313625065 cites W2112560527 @default.
• W4313625065 cites W2116475791 @default.
• W4313625065 cites W2117110037 @default.
• W4313625065 cites W2125435699 @default.
• W4313625065 cites W2141222928 @default.
• W4313625065 cites W2156098321 @default.
• W4313625065 cites W2157823046 @default.
• W4313625065 cites W2158260242 @default.
• W4313625065 cites W2582756960 @default.
• W4313625065 cites W2646836708 @default.
• W4313625065 cites W2748954699 @default.
• W4313625065 cites W2769400169 @default.
• W4313625065 cites W2887191177 @default.
• W4313625065 cites W2893737843 @default.
• W4313625065 cites W2904192843 @default.
• W4313625065 cites W2947269450 @default.
• W4313625065 cites W2967418426 @default.
• W4313625065 cites W2983748684 @default.
• W4313625065 cites W2990095623 @default.
• W4313625065 cites W2991792334 @default.
• W4313625065 cites W3021610488 @default.
• W4313625065 cites W3162939481 @default.
• W4313625065 cites W3183979618 @default.
• W4313625065 doi "https://doi.org/10.1097/md.0000000000032613" @default.
• W4313625065 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36607862" @default.
• W4313625065 hasPublicationYear "2023" @default.
• W4313625065 type Work @default.
• W4313625065 citedByCount "0" @default.
• W4313625065 crossrefType "journal-article" @default.
• W4313625065 hasAuthorship W4313625065A5028719956 @default.
• W4313625065 hasAuthorship W4313625065A5031957558 @default.
• W4313625065 hasAuthorship W4313625065A5058197133 @default.
• W4313625065 hasAuthorship W4313625065A5061284364 @default.
• W4313625065 hasAuthorship W4313625065A5073525543 @default.
• W4313625065 hasBestOaLocation W43136250651 @default.
• W4313625065 hasConcept C126322002 @default.
• W4313625065 hasConcept C134018914 @default.
• W4313625065 hasConcept C164705383 @default.
• W4313625065 hasConcept C187960798 @default.
• W4313625065 hasConcept C2776478404 @default.
• W4313625065 hasConcept C2777180221 @default.
• W4313625065 hasConcept C2778384471 @default.
• W4313625065 hasConcept C2910068830 @default.
• W4313625065 hasConcept C44249647 @default.
• W4313625065 hasConcept C555293320 @default.
• W4313625065 hasConcept C57900726 @default.
• W4313625065 hasConcept C71924100 @default.
• W4313625065 hasConcept C84393581 @default.
• W4313625065 hasConcept C95190672 @default.
• W4313625065 hasConceptScore W4313625065C126322002 @default.
• W4313625065 hasConceptScore W4313625065C134018914 @default.
• W4313625065 hasConceptScore W4313625065C164705383 @default.
• W4313625065 hasConceptScore W4313625065C187960798 @default.
• W4313625065 hasConceptScore W4313625065C2776478404 @default.
• W4313625065 hasConceptScore W4313625065C2777180221 @default.
• W4313625065 hasConceptScore W4313625065C2778384471 @default.
• W4313625065 hasConceptScore W4313625065C2910068830 @default.
• W4313625065 hasConceptScore W4313625065C44249647 @default.
• W4313625065 hasConceptScore W4313625065C555293320 @default.
• W4313625065 hasConceptScore W4313625065C57900726 @default.
• W4313625065 hasConceptScore W4313625065C71924100 @default.
• W4313625065 hasConceptScore W4313625065C84393581 @default.
• W4313625065 hasConceptScore W4313625065C95190672 @default.
• W4313625065 hasIssue "1" @default.
• W4313625065 hasLocation W43136250651 @default.
• W4313625065 hasLocation W43136250652 @default.
• W4313625065 hasLocation W43136250653 @default.
• W4313625065 hasLocation W43136250654 @default.
• W4313625065 hasOpenAccess W4313625065 @default.
• W4313625065 hasPrimaryLocation W43136250651 @default.
• W4313625065 hasRelatedWork W1048882278 @default.
• W4313625065 hasRelatedWork W3029759821 @default.
• W4313625065 hasRelatedWork W3044745925 @default.
• W4313625065 hasRelatedWork W3159849630 @default.
• W4313625065 hasRelatedWork W3184554080 @default.
• W4313625065 hasRelatedWork W3207611470 @default.
• W4313625065 hasRelatedWork W3213074919 @default.
• W4313625065 hasRelatedWork W4220828909 @default.
• W4313625065 hasRelatedWork W4291824836 @default.

• next