Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313640009> ?p ?o ?g. }
- W4313640009 abstract "Tumors meet their energy, biosynthesis, and redox demands through metabolic reprogramming. This metabolic abnormality results in elevated levels of metabolites, particularly lactate, in the tumor microenvironment. Immune cell reprogramming and cellular plasticity mediated by lactate and lactylation increase immunosuppression in the tumor microenvironment and are emerging as key factors in regulating tumor development, metastasis, and the effectiveness of immunotherapies such as immune checkpoint inhibitors. Reprogramming of glucose metabolism and the Warburg effect in hepatocellular carcinoma (HCC) lead to the massive production and accumulation of lactate, so lactate modification in tumor tissue is likely to be abnormal as well. This article reviews the immune regulation of abnormal lactate metabolism and lactate modification in hepatocellular carcinoma and the therapeutic strategy of targeting lactate-immunotherapy, which will help to better guide the medication and treatment of patients with hepatocellular carcinoma." @default.
- W4313640009 created "2023-01-07" @default.
- W4313640009 creator A5004349988 @default.
- W4313640009 creator A5006847122 @default.
- W4313640009 creator A5031171953 @default.
- W4313640009 creator A5047128762 @default.
- W4313640009 creator A5048546958 @default.
- W4313640009 creator A5053196164 @default.
- W4313640009 creator A5075155405 @default.
- W4313640009 date "2023-01-06" @default.
- W4313640009 modified "2023-10-18" @default.
- W4313640009 title "Research progress of abnormal lactate metabolism and lactate modification in immunotherapy of hepatocellular carcinoma" @default.
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