FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313640695> ?p ?o ?g. }

• W4313640695 endingPage "142" @default.
• W4313640695 startingPage "127" @default.
• W4313640695 abstract "Circular RNAs (circRNAs) are endogenous noncoding RNAs that play vital roles in many biological processes, particularly in human cancer. Recent studies indicate that circRNAs play an important role in tumor progression through exosomes. However, the specific functions of gastric cancer-derived exosomes and the role of circSTAU2 in gastric cancer (GC) remain largely unknown.Differentially expressed circRNAs in GC were identified by circRNA microarrays analysis and quantitative real-time polymerase chain reaction (qRT-PCR). The role of circSTAU2 in GC was verified by circSTAU2 knockdown and overexpression with functional assays both in vitro and in vivo. Fluorescence in situ hybridization (FISH), immunofluorescence, RNA immunoprecipitation (RIP), dual-luciferase reporter assay, qRT-PCR and Western blot were adopted to evaluate the expression and regulatory mechanism of MBNL1, circSTAU2, miR-589 and CAPZA1. Furthermore, the role of exosomes was demonstrated by transmission electron microscopy and nano-sight particle tracking analysis.CircSTAU2, mainly localized in the cytoplasm, was significantly downregulated in GC. CircSTAU2 overexpression inhibited GC cell proliferation, invasion and migration both in vitro and in vivo, while circSTAU2 knockdown had the inverse effect. CircSTAU2 could be wrapped in exosomes and delivered to recipient cells, and functioned as a sponge for miR-589 to relieve its inhibitory effect on CAPZA1, thus inhibiting GC progression. Furthermore, MBNL1 acted as the upstream RNA-binding protein of circSTAU2 and significantly influenced the circularization and expression of circSTAU2.Exosome-delivered circSTAU2 may act as a tumor suppressor that restrains GC progression via miR-589/CAPZA1 axis, which demonstrates a potential therapeutic target for GC." @default.
• W4313640695 created "2023-01-07" @default.
• W4313640695 creator A5000894136 @default.
• W4313640695 creator A5004666733 @default.
• W4313640695 creator A5022987262 @default.
• W4313640695 creator A5026277645 @default.
• W4313640695 creator A5030719289 @default.
• W4313640695 creator A5031567480 @default.
• W4313640695 creator A5042335120 @default.
• W4313640695 creator A5044330762 @default.
• W4313640695 creator A5056332234 @default.
• W4313640695 creator A5065915134 @default.
• W4313640695 creator A5067612393 @default.
• W4313640695 creator A5076768386 @default.
• W4313640695 date "2023-01-01" @default.
• W4313640695 modified "2023-09-26" @default.
• W4313640695 title "Exosome-Delivered circSTAU2 Inhibits the Progression of Gastric Cancer by Targeting the miR-589/CAPZA1 Axis" @default.
• W4313640695 cites W1846631206 @default.
• W4313640695 cites W1966557314 @default.
• W4313640695 cites W1998657632 @default.
• W4313640695 cites W2031593782 @default.
• W4313640695 cites W2044601473 @default.
• W4313640695 cites W2064165694 @default.
• W4313640695 cites W2084387121 @default.
• W4313640695 cites W2128361433 @default.
• W4313640695 cites W2562436083 @default.
• W4313640695 cites W2577192775 @default.
• W4313640695 cites W2765111042 @default.
• W4313640695 cites W2884482057 @default.
• W4313640695 cites W2892630678 @default.
• W4313640695 cites W2901528543 @default.
• W4313640695 cites W2912746027 @default.
• W4313640695 cites W2944131287 @default.
• W4313640695 cites W2954167484 @default.
• W4313640695 cites W2963503833 @default.
• W4313640695 cites W2964331590 @default.
• W4313640695 cites W2967043226 @default.
• W4313640695 cites W2982690182 @default.
• W4313640695 cites W3006437689 @default.
• W4313640695 cites W3006786463 @default.
• W4313640695 cites W3008243650 @default.
• W4313640695 cites W3013918681 @default.
• W4313640695 cites W3044582075 @default.
• W4313640695 cites W3047352808 @default.
• W4313640695 cites W3085127652 @default.
• W4313640695 cites W3097885939 @default.
• W4313640695 cites W3100281716 @default.
• W4313640695 cites W3115748476 @default.
• W4313640695 cites W3128646645 @default.
• W4313640695 cites W3131184953 @default.
• W4313640695 cites W3164777321 @default.
• W4313640695 cites W3170908111 @default.
• W4313640695 cites W3206742563 @default.
• W4313640695 cites W3213709497 @default.
• W4313640695 cites W4200074879 @default.
• W4313640695 cites W4200076129 @default.
• W4313640695 cites W4200547959 @default.
• W4313640695 cites W4210990885 @default.
• W4313640695 cites W4249579699 @default.
• W4313640695 doi "https://doi.org/10.2147/ijn.s391872" @default.
• W4313640695 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36643863" @default.
• W4313640695 hasPublicationYear "2023" @default.
• W4313640695 type Work @default.
• W4313640695 citedByCount "4" @default.
• W4313640695 countsByYear W43136406952023 @default.
• W4313640695 crossrefType "journal-article" @default.
• W4313640695 hasAuthorship W4313640695A5000894136 @default.
• W4313640695 hasAuthorship W4313640695A5004666733 @default.
• W4313640695 hasAuthorship W4313640695A5022987262 @default.
• W4313640695 hasAuthorship W4313640695A5026277645 @default.
• W4313640695 hasAuthorship W4313640695A5030719289 @default.
• W4313640695 hasAuthorship W4313640695A5031567480 @default.
• W4313640695 hasAuthorship W4313640695A5042335120 @default.
• W4313640695 hasAuthorship W4313640695A5044330762 @default.
• W4313640695 hasAuthorship W4313640695A5056332234 @default.
• W4313640695 hasAuthorship W4313640695A5065915134 @default.
• W4313640695 hasAuthorship W4313640695A5067612393 @default.
• W4313640695 hasAuthorship W4313640695A5076768386 @default.
• W4313640695 hasBestOaLocation W43136406951 @default.
• W4313640695 hasConcept C104317684 @default.
• W4313640695 hasConcept C145059251 @default.
• W4313640695 hasConcept C153911025 @default.
• W4313640695 hasConcept C173396325 @default.
• W4313640695 hasConcept C20518536 @default.
• W4313640695 hasConcept C2781261824 @default.
• W4313640695 hasConcept C502942594 @default.
• W4313640695 hasConcept C54355233 @default.
• W4313640695 hasConcept C55493867 @default.
• W4313640695 hasConcept C67705224 @default.
• W4313640695 hasConcept C81885089 @default.
• W4313640695 hasConcept C86803240 @default.
• W4313640695 hasConcept C95444343 @default.
• W4313640695 hasConceptScore W4313640695C104317684 @default.
• W4313640695 hasConceptScore W4313640695C145059251 @default.
• W4313640695 hasConceptScore W4313640695C153911025 @default.
• W4313640695 hasConceptScore W4313640695C173396325 @default.
• W4313640695 hasConceptScore W4313640695C20518536 @default.
• W4313640695 hasConceptScore W4313640695C2781261824 @default.

• next