Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313640970> ?p ?o ?g. }
- W4313640970 abstract "Atorvastatin calcium (ATV) is a well-known anti-hyperlipidemic drug currently being recognized for possessing an anti-inflammatory effect. Introducing it as a novel remedy for periodontitis treatment necessitates developing a syringeable modified delivery system capable of targeting inflammation within the periodontal pockets. Thus, a 33 Box-Behnken design was used to generate eugenol enriched PEGylated cubosomes. Based on the desirability function, the optimized formulation (OEEPC) was selected exhibiting a solubilization efficiency (SE%) of 97.71 ± 0.49%, particle size (PS) of 135.20 ± 1.11 nm, polydispersity index (PDI) of 0.09 ± 0.006, zeta potential (ZP) of -28.30 ± 1.84 mV and showing a sustained drug release over 12 h. It displayed a cubic structure under the transmission electron microscope, furthermore, it was stable upon storage for up to 30 days. Hence, it was loaded into an optimum syringeable in-situ gel (ISG) which displayed the desired periodontal gelation temperature (34 ± 0.70 °C) and an adequate gelation time (46 ± 2.82 sec), it also released approximately 75% of the drug within 72 h. Clinical evaluation of the ISG showed a promising percentage reduction of about 58.33% in probing depth, 90% in the bleeding index, 81.81% in the plaque index, and 70.21% in gingival levels of transforming growth factor-β1. This proved that the formulated syringeable intra-pocket delivery system of ATV is an efficient candidate for diminishing inflammation in periodontitis." @default.
- W4313640970 created "2023-01-07" @default.
- W4313640970 creator A5005999337 @default.
- W4313640970 creator A5010775514 @default.
- W4313640970 creator A5058816849 @default.
- W4313640970 creator A5067285251 @default.
- W4313640970 creator A5071286700 @default.
- W4313640970 date "2023-01-05" @default.
- W4313640970 modified "2023-09-27" @default.
- W4313640970 title "Syringeable atorvastatin loaded eugenol enriched PEGylated cubosomes in-situ gel for the intra-pocket treatment of periodontitis: statistical optimization and clinical assessment" @default.
- W4313640970 cites W1409608176 @default.
- W4313640970 cites W1561469338 @default.
- W4313640970 cites W1963714356 @default.
- W4313640970 cites W1967000099 @default.
- W4313640970 cites W1981556226 @default.
- W4313640970 cites W1994674246 @default.
- W4313640970 cites W2006795866 @default.
- W4313640970 cites W2011795481 @default.
- W4313640970 cites W2022494902 @default.
- W4313640970 cites W2035640123 @default.
- W4313640970 cites W2045031655 @default.
- W4313640970 cites W2047405247 @default.
- W4313640970 cites W2055400540 @default.
- W4313640970 cites W2063742084 @default.
- W4313640970 cites W2095946392 @default.
- W4313640970 cites W2104321840 @default.
- W4313640970 cites W2106496495 @default.
- W4313640970 cites W2121558706 @default.
- W4313640970 cites W2155151355 @default.
- W4313640970 cites W2156625142 @default.
- W4313640970 cites W2164125934 @default.
- W4313640970 cites W2168703741 @default.
- W4313640970 cites W2171075248 @default.
- W4313640970 cites W2297133030 @default.
- W4313640970 cites W2343363692 @default.
- W4313640970 cites W2397302576 @default.
- W4313640970 cites W2410537689 @default.
- W4313640970 cites W2417175953 @default.
- W4313640970 cites W2432883993 @default.
- W4313640970 cites W2529525545 @default.
- W4313640970 cites W2572709797 @default.
- W4313640970 cites W2583555428 @default.
- W4313640970 cites W2605563843 @default.
- W4313640970 cites W2612413951 @default.
- W4313640970 cites W2748920214 @default.
- W4313640970 cites W2765851533 @default.
- W4313640970 cites W2774900204 @default.
- W4313640970 cites W2805779846 @default.
- W4313640970 cites W2808124468 @default.
- W4313640970 cites W2891488942 @default.
- W4313640970 cites W2896291615 @default.
- W4313640970 cites W2898133507 @default.
- W4313640970 cites W2901476092 @default.
- W4313640970 cites W2913354299 @default.
- W4313640970 cites W2919171322 @default.
- W4313640970 cites W2928448122 @default.
- W4313640970 cites W2940058582 @default.
- W4313640970 cites W2942762534 @default.
- W4313640970 cites W2948608271 @default.
- W4313640970 cites W2971451226 @default.
- W4313640970 cites W2971973344 @default.
- W4313640970 cites W2997776240 @default.
- W4313640970 cites W2998955156 @default.
- W4313640970 cites W3014756135 @default.
- W4313640970 cites W3021561583 @default.
- W4313640970 cites W3025433107 @default.
- W4313640970 cites W3033901873 @default.
- W4313640970 cites W3043090411 @default.
- W4313640970 cites W3087809905 @default.
- W4313640970 cites W3088916776 @default.
- W4313640970 cites W3093721332 @default.
- W4313640970 cites W3112231535 @default.
- W4313640970 cites W3113042459 @default.
- W4313640970 cites W3116369909 @default.
- W4313640970 cites W3133300633 @default.
- W4313640970 cites W3138140638 @default.
- W4313640970 cites W3159818311 @default.
- W4313640970 cites W3173401919 @default.
- W4313640970 cites W3192999754 @default.
- W4313640970 cites W4220904301 @default.
- W4313640970 cites W4224593730 @default.
- W4313640970 cites W4281489788 @default.
- W4313640970 doi "https://doi.org/10.1080/10717544.2022.2162159" @default.
- W4313640970 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36604813" @default.
- W4313640970 hasPublicationYear "2023" @default.
- W4313640970 type Work @default.
- W4313640970 citedByCount "1" @default.
- W4313640970 countsByYear W43136409702023 @default.
- W4313640970 crossrefType "journal-article" @default.
- W4313640970 hasAuthorship W4313640970A5005999337 @default.
- W4313640970 hasAuthorship W4313640970A5010775514 @default.
- W4313640970 hasAuthorship W4313640970A5058816849 @default.
- W4313640970 hasAuthorship W4313640970A5067285251 @default.
- W4313640970 hasAuthorship W4313640970A5071286700 @default.
- W4313640970 hasBestOaLocation W43136409701 @default.
- W4313640970 hasConcept C11432220 @default.
- W4313640970 hasConcept C136229726 @default.
- W4313640970 hasConcept C155672457 @default.
- W4313640970 hasConcept C171250308 @default.
- W4313640970 hasConcept C178790620 @default.