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- W4313641014 endingPage "206" @default.
- W4313641014 startingPage "195" @default.
- W4313641014 abstract "Trypanosomatids are protozoan parasites that cause human and animal neglected diseases. Despite global efforts, effective treatments are still much needed. Phenotypic screens have provided several chemical leads for drug discovery, but the mechanism of action for many of these chemicals is currently unknown. Recently, chemogenomic screens assessing the susceptibility or resistance of parasites carrying genome-wide modifications started to define the mechanism of action of drugs at large scale. In this review, we discuss how genomics is being used for drug discovery in trypanosomatids, how integration of chemical and genomics data from these and other organisms has guided prioritisations of candidate therapeutic targets and additional chemical starting points, and how these data can fuel the expansion of drug discovery pipelines into the era of artificial intelligence." @default.
- W4313641014 created "2023-01-07" @default.
- W4313641014 creator A5054325712 @default.
- W4313641014 creator A5065556885 @default.
- W4313641014 creator A5077801542 @default.
- W4313641014 date "2023-01-06" @default.
- W4313641014 modified "2023-10-06" @default.
- W4313641014 title "Targeting trypanosomes: how chemogenomics and artificial intelligence can guide drug discovery" @default.
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