FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313641284> ?p ?o ?g. }

• W4313641284 endingPage "244" @default.
• W4313641284 startingPage "244" @default.
• W4313641284 abstract "With the advent of nanotechnology, the use of nanoparticles as drug delivery system (DDS) has attracted great interest. We aimed to apply carbon nanohorns (CNHs) as DDS in the development of new treatments for bone diseases. We evaluated the in vitro and in vivo cellular responses of CNHs in bone-related cells compared with carbon blacks (CBs), which are similar in particle size but differ in surface and structural morphologies. Although in vitro experiments revealed that both CNHs and CBs were incorporated into the lysosomes of RAW264-induced osteoclast-like cells (OCs) and MC3T3-E1 osteoblast-like cells (OBs), no severe cytotoxicity was observed. CNHs reduced the tartrate-resistant acid phosphatase activity and expression of the differentiation marker genes in OCs at noncytotoxic concentrations, whereas the alkaline phosphatase activity and differentiation of OBs increased. Under calcification of OBs, CNHs increased the number of calcified nodules and were intra- and extracellularly incorporated into calcified vesicles to form crystal nuclei. The in vivo experiments showed significant promotion of bone regeneration in the CNH group alone, with localized CNHs being found in the bone matrix and lacunae. The suppression of OCs and promotion of OBs suggested that CNHs may be effective against bone diseases and could be applied as DDS." @default.
• W4313641284 created "2023-01-07" @default.
• W4313641284 creator A5016784676 @default.
• W4313641284 creator A5018022829 @default.
• W4313641284 creator A5035105246 @default.
• W4313641284 creator A5039668331 @default.
• W4313641284 creator A5051655941 @default.
• W4313641284 creator A5053034528 @default.
• W4313641284 creator A5062156183 @default.
• W4313641284 creator A5082341432 @default.
• W4313641284 creator A5084895453 @default.
• W4313641284 date "2023-01-05" @default.
• W4313641284 modified "2023-10-14" @default.
• W4313641284 title "Biocompatibility Evaluation of Carbon Nanohorns in Bone Tissues" @default.
• W4313641284 cites W1757165467 @default.
• W4313641284 cites W1982372788 @default.
• W4313641284 cites W1983421023 @default.
• W4313641284 cites W2009298620 @default.
• W4313641284 cites W2021496901 @default.
• W4313641284 cites W2022047303 @default.
• W4313641284 cites W2028921565 @default.
• W4313641284 cites W2046251407 @default.
• W4313641284 cites W2086718972 @default.
• W4313641284 cites W2092246326 @default.
• W4313641284 cites W2157299977 @default.
• W4313641284 cites W2341375611 @default.
• W4313641284 cites W2475177397 @default.
• W4313641284 cites W2602684234 @default.
• W4313641284 cites W2607389452 @default.
• W4313641284 cites W2890167612 @default.
• W4313641284 cites W2894995576 @default.
• W4313641284 cites W2958376892 @default.
• W4313641284 cites W2973377030 @default.
• W4313641284 cites W3011911306 @default.
• W4313641284 cites W3118581752 @default.
• W4313641284 cites W3126694762 @default.
• W4313641284 cites W4294151928 @default.
• W4313641284 cites W4294948543 @default.
• W4313641284 doi "https://doi.org/10.3390/nano13020244" @default.
• W4313641284 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36677997" @default.
• W4313641284 hasPublicationYear "2023" @default.
• W4313641284 type Work @default.
• W4313641284 citedByCount "0" @default.
• W4313641284 crossrefType "journal-article" @default.
• W4313641284 hasAuthorship W4313641284A5016784676 @default.
• W4313641284 hasAuthorship W4313641284A5018022829 @default.
• W4313641284 hasAuthorship W4313641284A5035105246 @default.
• W4313641284 hasAuthorship W4313641284A5039668331 @default.
• W4313641284 hasAuthorship W4313641284A5051655941 @default.
• W4313641284 hasAuthorship W4313641284A5053034528 @default.
• W4313641284 hasAuthorship W4313641284A5062156183 @default.
• W4313641284 hasAuthorship W4313641284A5082341432 @default.
• W4313641284 hasAuthorship W4313641284A5084895453 @default.
• W4313641284 hasBestOaLocation W43136412841 @default.
• W4313641284 hasConcept C109316439 @default.
• W4313641284 hasConcept C150903083 @default.
• W4313641284 hasConcept C160160445 @default.
• W4313641284 hasConcept C178790620 @default.
• W4313641284 hasConcept C181199279 @default.
• W4313641284 hasConcept C185592680 @default.
• W4313641284 hasConcept C202751555 @default.
• W4313641284 hasConcept C207001950 @default.
• W4313641284 hasConcept C2776033226 @default.
• W4313641284 hasConcept C2777230088 @default.
• W4313641284 hasConcept C2778260815 @default.
• W4313641284 hasConcept C55493867 @default.
• W4313641284 hasConcept C86803240 @default.
• W4313641284 hasConcept C95444343 @default.
• W4313641284 hasConceptScore W4313641284C109316439 @default.
• W4313641284 hasConceptScore W4313641284C150903083 @default.
• W4313641284 hasConceptScore W4313641284C160160445 @default.
• W4313641284 hasConceptScore W4313641284C178790620 @default.
• W4313641284 hasConceptScore W4313641284C181199279 @default.
• W4313641284 hasConceptScore W4313641284C185592680 @default.
• W4313641284 hasConceptScore W4313641284C202751555 @default.
• W4313641284 hasConceptScore W4313641284C207001950 @default.
• W4313641284 hasConceptScore W4313641284C2776033226 @default.
• W4313641284 hasConceptScore W4313641284C2777230088 @default.
• W4313641284 hasConceptScore W4313641284C2778260815 @default.
• W4313641284 hasConceptScore W4313641284C55493867 @default.
• W4313641284 hasConceptScore W4313641284C86803240 @default.
• W4313641284 hasConceptScore W4313641284C95444343 @default.
• W4313641284 hasIssue "2" @default.
• W4313641284 hasLocation W43136412841 @default.
• W4313641284 hasLocation W43136412842 @default.
• W4313641284 hasLocation W43136412843 @default.
• W4313641284 hasLocation W43136412844 @default.
• W4313641284 hasLocation W43136412845 @default.
• W4313641284 hasLocation W43136412846 @default.
• W4313641284 hasOpenAccess W4313641284 @default.
• W4313641284 hasPrimaryLocation W43136412841 @default.
• W4313641284 hasRelatedWork W1982027601 @default.
• W4313641284 hasRelatedWork W200909032 @default.
• W4313641284 hasRelatedWork W2029466194 @default.
• W4313641284 hasRelatedWork W2051275279 @default.
• W4313641284 hasRelatedWork W2076847811 @default.
• W4313641284 hasRelatedWork W2148676064 @default.
• W4313641284 hasRelatedWork W2370648588 @default.

• next