Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313641326> ?p ?o ?g. }
- W4313641326 endingPage "540" @default.
- W4313641326 startingPage "540" @default.
- W4313641326 abstract "In this study, new 7-chloro-4-aminoquinoline-benzimidazole compounds were synthesized and characterized by NMR, MS, and elemental analysis. These novel hybrids differ in the type of linker and in the substituent on the benzimidazole moiety. Their antiproliferative activities were evaluated on one non-tumor (MDCK1) and seven selected tumor (CaCo-2, MCF-7, CCRF-CEM, Hut78, THP-1, and Raji) cell lines by MTT test and flow cytometry analysis. The compounds with different types of linkers and an unsubstituted benzimidazole ring, 5d, 8d, and 12d, showed strong cytotoxic activity (the GI50 ranged from 0.4 to 8 µM) and effectively suppressed the cell cycle progression in the leukemia and lymphoma cells. After 24 h of treatment, compounds 5d and 12d induced the disruption of the mitochondrial membrane potential as well as apoptosis in HuT78 cells. The drug-like properties and bioavailability of the compounds were calculated using the Swiss ADME web tool, and a molecular docking study was performed on tyrosine-protein kinase c-Src (PDB: 3G6H). Compound 12d showed good solubility and permeability and bound to c-Src with an energy of -119.99 kcal/mol, forming hydrogen bonds with Glu310 and Asp404 in the active site and other residues with van der Waals interactions. The results suggest that compound 12d could be a leading compound in the further design of effective antitumor drugs." @default.
- W4313641326 created "2023-01-07" @default.
- W4313641326 creator A5004001928 @default.
- W4313641326 creator A5011046957 @default.
- W4313641326 creator A5014180656 @default.
- W4313641326 creator A5025610038 @default.
- W4313641326 creator A5025767030 @default.
- W4313641326 creator A5032876917 @default.
- W4313641326 creator A5042328772 @default.
- W4313641326 creator A5068381616 @default.
- W4313641326 creator A5069786537 @default.
- W4313641326 creator A5075332454 @default.
- W4313641326 date "2023-01-05" @default.
- W4313641326 modified "2023-10-09" @default.
- W4313641326 title "Novel 7-Chloro-4-aminoquinoline-benzimidazole Hybrids as Inhibitors of Cancer Cells Growth: Synthesis, Antiproliferative Activity, in Silico ADME Predictions, and Docking" @default.
- W4313641326 cites W1973190795 @default.
- W4313641326 cites W1975833163 @default.
- W4313641326 cites W1982629676 @default.
- W4313641326 cites W1992711346 @default.
- W4313641326 cites W2005104196 @default.
- W4313641326 cites W2007070530 @default.
- W4313641326 cites W2007495243 @default.
- W4313641326 cites W2009867031 @default.
- W4313641326 cites W2032116260 @default.
- W4313641326 cites W2043789128 @default.
- W4313641326 cites W2114259235 @default.
- W4313641326 cites W2114918609 @default.
- W4313641326 cites W2118909720 @default.
- W4313641326 cites W2132717026 @default.
- W4313641326 cites W2135732933 @default.
- W4313641326 cites W2152233061 @default.
- W4313641326 cites W2156973770 @default.
- W4313641326 cites W2160605524 @default.
- W4313641326 cites W2169495846 @default.
- W4313641326 cites W2507925007 @default.
- W4313641326 cites W2517149189 @default.
- W4313641326 cites W2567172118 @default.
- W4313641326 cites W2593436234 @default.
- W4313641326 cites W2605478093 @default.
- W4313641326 cites W2605709730 @default.
- W4313641326 cites W2613674673 @default.
- W4313641326 cites W2619068808 @default.
- W4313641326 cites W2768032084 @default.
- W4313641326 cites W2793972506 @default.
- W4313641326 cites W2889058619 @default.
- W4313641326 cites W2890873210 @default.
- W4313641326 cites W2904243030 @default.
- W4313641326 cites W2910194312 @default.
- W4313641326 cites W2913342929 @default.
- W4313641326 cites W2924195289 @default.
- W4313641326 cites W2935887716 @default.
- W4313641326 cites W2953195599 @default.
- W4313641326 cites W2964452673 @default.
- W4313641326 cites W2973060429 @default.
- W4313641326 cites W2981315210 @default.
- W4313641326 cites W2995713331 @default.
- W4313641326 cites W3012638502 @default.
- W4313641326 cites W3015032733 @default.
- W4313641326 cites W3020683813 @default.
- W4313641326 cites W3029660293 @default.
- W4313641326 cites W3038044033 @default.
- W4313641326 cites W3047461031 @default.
- W4313641326 cites W3111964983 @default.
- W4313641326 cites W3125877452 @default.
- W4313641326 cites W3128646645 @default.
- W4313641326 cites W3138096992 @default.
- W4313641326 cites W3144915612 @default.
- W4313641326 cites W3148544959 @default.
- W4313641326 cites W3148800244 @default.
- W4313641326 cites W3159268107 @default.
- W4313641326 cites W3193513064 @default.
- W4313641326 cites W3204838168 @default.
- W4313641326 cites W4200191138 @default.
- W4313641326 cites W4206841660 @default.
- W4313641326 cites W4224250555 @default.
- W4313641326 cites W4225424647 @default.
- W4313641326 cites W4231421929 @default.
- W4313641326 cites W4249737499 @default.
- W4313641326 cites W4283319072 @default.
- W4313641326 cites W4283466659 @default.
- W4313641326 cites W4293769577 @default.
- W4313641326 cites W4306399260 @default.
- W4313641326 cites W4306742844 @default.
- W4313641326 cites W4308952600 @default.
- W4313641326 cites W4311268687 @default.
- W4313641326 doi "https://doi.org/10.3390/molecules28020540" @default.
- W4313641326 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36677600" @default.
- W4313641326 hasPublicationYear "2023" @default.
- W4313641326 type Work @default.
- W4313641326 citedByCount "7" @default.
- W4313641326 countsByYear W43136413262023 @default.
- W4313641326 crossrefType "journal-article" @default.
- W4313641326 hasAuthorship W4313641326A5004001928 @default.
- W4313641326 hasAuthorship W4313641326A5011046957 @default.
- W4313641326 hasAuthorship W4313641326A5014180656 @default.
- W4313641326 hasAuthorship W4313641326A5025610038 @default.
- W4313641326 hasAuthorship W4313641326A5025767030 @default.
- W4313641326 hasAuthorship W4313641326A5032876917 @default.