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- W4313641395 abstract "Abstract We examined the efficacy and safety of Liushen pill combined with basic treatment for patients with COVID‐19. In total, 181 patients hospitalized with COVID‐19, classified as asymptomatic mild type, were randomly divided into the experimental ( n = 91) and control ( n = 90) groups and were administered placebo (Maizao decoction) and Maizao decoction and Liushen pill, in addition to standard care, respectively. The negative conversion rate of nucleic acid (Day 7), hospital discharge rate (Days 8, 10, and 14), symptom disappearance rate (Days 3, 5, and 7), inflammatory cytokine levels, and adverse events were compared between the groups. The negative viral conversion rate was significantly higher in the experimental than in the control group (48.35 vs. 31.11%, p < 0.05). Subgroup analysis showed a similar significant trend when the Ct value was ≤30 at baseline. After 10 days, the hospital discharge rate was significantly higher in the experimental than in the control group (69.23 vs. 53.33%, p < 0.05). After 3‐day medication, the headache symptoms significantly disappeared in the experimental (88.57%) compared to the control group (63.33%) ( p < 0.05). After 5 days, the symptom disappearance rates of headache and cough were significantly higher in the experimental (97.14%) than in the control group (97.14 vs. 80.00, p < 0.05; 82.65 vs. 58.93%, p < 0.01, respectively). Posttreatment, the procalcitonin level was significantly lower in the experimental than in the control group (0.09 ± 0.00 vs. 0.14 ± 0.05 ng/L; p < 0.05). There were no significant between‐group differences in clinical safety test indices. Early intervention with Liushen pill improved cough and headache and increased negative viral conversion and discharge rate." @default.
- W4313641395 created "2023-01-07" @default.
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- W4313641395 date "2023-01-01" @default.
- W4313641395 modified "2023-10-14" @default.
- W4313641395 title "Oral Liushen pill for patients with COVID‐19: A prospective randomized controlled trial" @default.
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- W4313641395 doi "https://doi.org/10.1002/pul2.12187" @default.
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