Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313641983> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W4313641983 endingPage "S32" @default.
- W4313641983 startingPage "S31" @default.
- W4313641983 abstract "Objective To determine if testing for N-type voltage-gated calcium channel antibody improves diagnostic performance of serological testing for Lambert-Eaton Myasthenic Syndrome. Background Patients with suspected autoimmune neuromuscular junction transmission disorders are commonly tested for both P/Q-type (VGCC-P/Q) and N-type (VGCC-N) voltage-gated calcium channel antibodies to aid the diagnosis of Lambert-Eaton Myasthenic Syndrome (LEMS). Design/Methods This retrospective cross-sectional study included 93 patients diagnosed at Mayo Clinic with LEMS based on electrodiagnostic findings, clinical presentation and positive serology for VGCC-P/Q and/or VGCC-N. Results Forty-five patients (48.4%) were female, of median age 61 years (range 11- 99). Twenty-five (26.9%) were positive for both VGCC antibody types (reference interval <0.04 nmol/L [VGCC-N] and <0.03 nmol/L [VGCC-P/Q]); 67 (72.0%) were positive for VGCC-P/Q only and one (1.1%) was positive for VGCC-N only. The single VGCC-N positive only result [VGCC-N = 0.10 nmol/L; VGCC-PQ = 0.02 nmol/L] was from a patient with classic LEMS presentation and no evidence of malignancy by Chest CT. The prevalence of VGCC-N only positivity was lower than in the healthy population or other disease control populations. VGCC-P/Q antibody titers were higher in patients who had detectable co-existing VGCC-N antibody (median titer 1.58 versus 0.39 nmol/L, P = 0.02) and there was a positive correlation (r = 0.762, P < 0.001) between VGCC-N and VGCC-P/Q titers in double positive cases. Dual positivity did not significantly increase the likelihood of an underlying cancer (40.9% versus 30.1%, P = 0.33). Conclusions Testing for VGCC-P/Q antibodies alone is sufficient in the serological evaluation of suspected LEMS cases. Inclusion of VGCC-N antibody testing does not improve diagnostic performance. A positive VGCC-N antibody did not significantly increase the risk of paraneoplastic LEMS." @default.
- W4313641983 created "2023-01-07" @default.
- W4313641983 creator A5028503045 @default.
- W4313641983 creator A5032608043 @default.
- W4313641983 creator A5053780989 @default.
- W4313641983 creator A5055122406 @default.
- W4313641983 creator A5077668464 @default.
- W4313641983 creator A5086468988 @default.
- W4313641983 creator A5088136783 @default.
- W4313641983 creator A5088963233 @default.
- W4313641983 date "2022-12-05" @default.
- W4313641983 modified "2023-09-28" @default.
- W4313641983 title "Testing for N-type Voltage Gated Calcium Channel Antibody has Limited Utility in Evaluating Patients With Suspected Lambert-Eaton Myasthenic Syndrome" @default.
- W4313641983 doi "https://doi.org/10.1212/01.wnl.0000903272.62514.70" @default.
- W4313641983 hasPublicationYear "2022" @default.
- W4313641983 type Work @default.
- W4313641983 citedByCount "0" @default.
- W4313641983 crossrefType "journal-article" @default.
- W4313641983 hasAuthorship W4313641983A5028503045 @default.
- W4313641983 hasAuthorship W4313641983A5032608043 @default.
- W4313641983 hasAuthorship W4313641983A5053780989 @default.
- W4313641983 hasAuthorship W4313641983A5055122406 @default.
- W4313641983 hasAuthorship W4313641983A5077668464 @default.
- W4313641983 hasAuthorship W4313641983A5086468988 @default.
- W4313641983 hasAuthorship W4313641983A5088136783 @default.
- W4313641983 hasAuthorship W4313641983A5088963233 @default.
- W4313641983 hasConcept C126322002 @default.
- W4313641983 hasConcept C159654299 @default.
- W4313641983 hasConcept C187212893 @default.
- W4313641983 hasConcept C203014093 @default.
- W4313641983 hasConcept C2777764698 @default.
- W4313641983 hasConcept C2778105408 @default.
- W4313641983 hasConcept C32611913 @default.
- W4313641983 hasConcept C45189115 @default.
- W4313641983 hasConcept C71924100 @default.
- W4313641983 hasConcept C90924648 @default.
- W4313641983 hasConceptScore W4313641983C126322002 @default.
- W4313641983 hasConceptScore W4313641983C159654299 @default.
- W4313641983 hasConceptScore W4313641983C187212893 @default.
- W4313641983 hasConceptScore W4313641983C203014093 @default.
- W4313641983 hasConceptScore W4313641983C2777764698 @default.
- W4313641983 hasConceptScore W4313641983C2778105408 @default.
- W4313641983 hasConceptScore W4313641983C32611913 @default.
- W4313641983 hasConceptScore W4313641983C45189115 @default.
- W4313641983 hasConceptScore W4313641983C71924100 @default.
- W4313641983 hasConceptScore W4313641983C90924648 @default.
- W4313641983 hasIssue "23" @default.
- W4313641983 hasLocation W43136419831 @default.
- W4313641983 hasOpenAccess W4313641983 @default.
- W4313641983 hasPrimaryLocation W43136419831 @default.
- W4313641983 hasRelatedWork W2016492860 @default.
- W4313641983 hasRelatedWork W2029098033 @default.
- W4313641983 hasRelatedWork W2035605467 @default.
- W4313641983 hasRelatedWork W2068377708 @default.
- W4313641983 hasRelatedWork W2069448174 @default.
- W4313641983 hasRelatedWork W2071610497 @default.
- W4313641983 hasRelatedWork W2324954285 @default.
- W4313641983 hasRelatedWork W2409592551 @default.
- W4313641983 hasRelatedWork W2609987844 @default.
- W4313641983 hasRelatedWork W2140435033 @default.
- W4313641983 hasVolume "99" @default.
- W4313641983 isParatext "false" @default.
- W4313641983 isRetracted "false" @default.
- W4313641983 workType "article" @default.