Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313642081> ?p ?o ?g. }
Showing items 1 to 59 of
59
with 100 items per page.
- W4313642081 abstract "Aryl/heteroarylsulfonamides are an important group of compounds with different directions of biological activity. The number of literature reports on the antibacterial activity of sulfonamides is steadily increasing, bringing a lot of interesting data on the diverse structures and mechanisms of their pharmacological action. The presented research joins the stream of the search for new hybrid molecules being created as a result of the combination of various pharmacophores with interesting biological profiles. Particular attention was paid to their antibacterial activity. The new compounds were designed and obtained based on the structure of the pharmacophore group of 4-chlorobenzenesulfonamide functionalized in the 2-position on sulfur atom, and the structure of chalcone. Taking into account the previous results of our own research and the available literature data, new N-(4-chloro-2-arylmethylthio-5-methylphenylsulfonyl)cinnamamide derivatives were designed and synthesized, which have pharmacophore groups in their structure, such as: 1-naphthylmethylthio and 6-chloropiperonylthio. Preliminary microbiological analysis was performed using TLC-bioautography. The expected antibacterial activity of the obtained compounds was confirmed inin vitrotests against Gram-positive bacteria: S. aureus, S. epimermidis, E. hirae, E. faecalis, and B. subtilis. In the next stage, the microbiological activity of selected compounds against clinical strains MRSA, CNS, and MRSE was also tested. The derivatives’ activity against bacterial biofilm and hemolytic activity on the peripheral blood of domestic sheep were also tested." @default.
- W4313642081 created "2023-01-07" @default.
- W4313642081 creator A5039236964 @default.
- W4313642081 creator A5070510196 @default.
- W4313642081 creator A5075527892 @default.
- W4313642081 date "2022-11-01" @default.
- W4313642081 modified "2023-10-18" @default.
- W4313642081 title "Evaluation of the Antimicrobial Activity of N-Acylated 4-Chloro-2-mercaptobenzenesulfonamide Derivatives" @default.
- W4313642081 doi "https://doi.org/10.3390/ecmc2022-13289" @default.
- W4313642081 hasPublicationYear "2022" @default.
- W4313642081 type Work @default.
- W4313642081 citedByCount "0" @default.
- W4313642081 crossrefType "proceedings-article" @default.
- W4313642081 hasAuthorship W4313642081A5039236964 @default.
- W4313642081 hasAuthorship W4313642081A5070510196 @default.
- W4313642081 hasAuthorship W4313642081A5075527892 @default.
- W4313642081 hasBestOaLocation W43136420811 @default.
- W4313642081 hasConcept C116073593 @default.
- W4313642081 hasConcept C178790620 @default.
- W4313642081 hasConcept C185592680 @default.
- W4313642081 hasConcept C202751555 @default.
- W4313642081 hasConcept C21951064 @default.
- W4313642081 hasConcept C2780104969 @default.
- W4313642081 hasConcept C4937899 @default.
- W4313642081 hasConcept C523546767 @default.
- W4313642081 hasConcept C54355233 @default.
- W4313642081 hasConcept C55493867 @default.
- W4313642081 hasConcept C56173144 @default.
- W4313642081 hasConcept C71240020 @default.
- W4313642081 hasConcept C86803240 @default.
- W4313642081 hasConceptScore W4313642081C116073593 @default.
- W4313642081 hasConceptScore W4313642081C178790620 @default.
- W4313642081 hasConceptScore W4313642081C185592680 @default.
- W4313642081 hasConceptScore W4313642081C202751555 @default.
- W4313642081 hasConceptScore W4313642081C21951064 @default.
- W4313642081 hasConceptScore W4313642081C2780104969 @default.
- W4313642081 hasConceptScore W4313642081C4937899 @default.
- W4313642081 hasConceptScore W4313642081C523546767 @default.
- W4313642081 hasConceptScore W4313642081C54355233 @default.
- W4313642081 hasConceptScore W4313642081C55493867 @default.
- W4313642081 hasConceptScore W4313642081C56173144 @default.
- W4313642081 hasConceptScore W4313642081C71240020 @default.
- W4313642081 hasConceptScore W4313642081C86803240 @default.
- W4313642081 hasLocation W43136420811 @default.
- W4313642081 hasOpenAccess W4313642081 @default.
- W4313642081 hasPrimaryLocation W43136420811 @default.
- W4313642081 hasRelatedWork W116013594 @default.
- W4313642081 hasRelatedWork W2033696307 @default.
- W4313642081 hasRelatedWork W2046594262 @default.
- W4313642081 hasRelatedWork W2147172480 @default.
- W4313642081 hasRelatedWork W2399363405 @default.
- W4313642081 hasRelatedWork W2999158156 @default.
- W4313642081 hasRelatedWork W2999431177 @default.
- W4313642081 hasRelatedWork W4206185500 @default.
- W4313642081 hasRelatedWork W2181909711 @default.
- W4313642081 hasRelatedWork W2184734085 @default.
- W4313642081 isParatext "false" @default.
- W4313642081 isRetracted "false" @default.
- W4313642081 workType "article" @default.