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- W4313642784 abstract "Background Carbon monoxide (CO) poisoning can cause tissue injury. Neutrophil granulocytes have been proposed to contribute to the injury, which may be ameliorated by hyperbaric oxygen (HBO 2 ) treatment. We sought to assess the relationship between acute CO poisoning and blood neutrophil count, plasma cytokine, and Cortisol responses, as well as the mechanism behind the observed beneficiary effects of HBO 2 treatment. Methods Eight patients (age 26–82 years) with severe acute CO poisoning were enrolled, concomitant with eight healthy controls (age 27–42 years), in a prospective, controlled, clinical study. The patients were given three HBO 2 treatments (2.8 atmospheres absolute, 100 minutes) within the first 24 hours. The controls were given identical simultaneous HBO 2 treatments. Venous blood samples were taken before and after each treatment. Results At the start of the HBO 2 treatment, patients displayed significantly higher blood neutrophil counts ( p < .0001) and plasma Cortisol levels (p = .020) than controls, but the two groups had similar values for interleukin-8, granulocyte colony-stimulating factor (G-CSF), neutrophil H 2 O 2 generation, and CD16 and CD18 surface expression. During the observation time, neutrophil H 2 O 2 accumulation declined in patients and in controls ( p = .031), whereas the up-regulation of CD18 expression increased ( p = .002) in both groups. Moreover, G-CSF levels became significantly higher in patients than in controls ( p = .015). G-CSF levels also correlated significantly with neutrophil counts. Conclusion CO poisoning was associated with discrete changes of blood neutrophil counts, Cortisol, and G-CSF plasma concentrations. HBO 2 treatment modulated neutrophil generation of H 2 O 2 and surface expression of CD18. These changes may be part of the cascade of events leading to the sequelae of CO poisoning and their attenuation by HBO 2 ." @default.
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- W4313642784 date "2004-12-01" @default.
- W4313642784 modified "2023-10-16" @default.
- W4313642784 title "Effects of Carbon Monoxide Poisoning on Neutrophil Responses in Patients Treated with Hyperbaric Oxygen" @default.
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- W4313642784 doi "https://doi.org/10.1177/108155890405200824" @default.
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