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• W4313643054 endingPage "366" @default.
• W4313643054 startingPage "317" @default.
• W4313643054 abstract "Learning lessons from basic research is not only a philosophical issue; it also has practical ramifications. This also applies especially to directed evolution of stereo- and/or regio-selective enzymes that are used in synthetic organic and pharmaceutical chemistry, where two different types of lessons are learned: (i) Unraveling the reasons for altered catalytic profiles leads to knowledge of hitherto unnoticed mechanistic intricacies, which in turn aids subsequent protein engineering for further improvements, enabling practical applications. (ii) Discovering that the best mutagenesis methods and strategies generate multi-mutational variants in which the effects of point mutations and sets of point mutations are more than additive (cooperative). This in turn speeds up the development of efficient protein engineering in directed evolution and in rational enzyme design and suggests further theoretical investigations." @default.
• W4313643054 created "2023-01-07" @default.
• W4313643054 date "2023-01-06" @default.
• W4313643054 modified "2023-10-02" @default.
• W4313643054 title "Learning Lessons from Protein Engineering" @default.
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