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- W4313643485 abstract "Nanocarriers have become an effective strategy to overcome epithelial absorption barriers. During the absorption process, the endocytosis mechanisms, cell internalization pathways, and transport efficiency of nanocarriers are greatly impacted by their physical properties. To understand the relationship between physical properties of nanocarriers and their abilities overcoming multiple absorption barriers, nanocarriers with variable physical properties were prepared via self-assembly of hydrolyzed α-lactalbumin peptide fragments. The impacts of size, shape, and rigidity of nanocarriers on epithelial cells endocytosis mechanisms, internalization pathways, transport efficiency, and bioavailability were studied systematically. The results showed that nanospheres were mainly internalized via clathrin-mediated endocytosis, which was then locked in lysosomes and degraded enzymatically in cytoplasm. While macropinocytosis was the primary pathway of nanotubes and transported to the endoplasmic reticulum and Golgi apparatus, resulting in a high drug concentration and sustained release in cytoplasm. Besides, nanotubes can overcome the multi-drug resistance by inhibiting the P-glycoprotein efflux. Furthermore, nanotubes can open intercellular tight-junctions instantaneously and reversibly, which promotes transport into blood circulation. The aqueous solubility of hydrophobic bioactive mangiferin (Mgf) was improved by nanocarriers. Most importantly, the bioavailability of Mgf was the highest for cross-linked short nanotube (CSNT) which outperformed free Mgf and other formulations by in vivo pharmacokinetic studies. Finally, Mgf-loaded CSNT showed an excellent therapeutic efficiency in vivo for the intervention of streptozotocin-induced diabetes. These results indicate that cross-linked α-lactalbumin nanotubes could be an effective nanocarrier delivery system for improving the epithelium cellular absorption and bioavailability of hydrophobic bioactive compounds." @default.
- W4313643485 created "2023-01-07" @default.
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- W4313643485 date "2023-03-01" @default.
- W4313643485 modified "2023-10-18" @default.
- W4313643485 title "The intracellular fate and transport mechanism of shape, size and rigidity varied nanocarriers for understanding their oral delivery efficiency" @default.
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- W4313643485 cites W1990620703 @default.
- W4313643485 cites W2002543077 @default.
- W4313643485 cites W2007319420 @default.
- W4313643485 cites W2009348679 @default.
- W4313643485 cites W2023872345 @default.
- W4313643485 cites W2034610978 @default.
- W4313643485 cites W2040243871 @default.
- W4313643485 cites W2046398431 @default.
- W4313643485 cites W2049949158 @default.
- W4313643485 cites W2053823417 @default.
- W4313643485 cites W2054454795 @default.
- W4313643485 cites W2057733044 @default.
- W4313643485 cites W2067306688 @default.
- W4313643485 cites W2076515532 @default.
- W4313643485 cites W2081663815 @default.
- W4313643485 cites W2082481556 @default.
- W4313643485 cites W2088896469 @default.
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- W4313643485 cites W2277399603 @default.
- W4313643485 cites W2314687124 @default.
- W4313643485 cites W2319217905 @default.
- W4313643485 cites W2346470490 @default.
- W4313643485 cites W2553630142 @default.
- W4313643485 cites W2590680367 @default.
- W4313643485 cites W2605696265 @default.
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- W4313643485 cites W2905139889 @default.
- W4313643485 cites W2917063036 @default.
- W4313643485 cites W2950887770 @default.
- W4313643485 cites W2968158681 @default.
- W4313643485 cites W2981223839 @default.
- W4313643485 cites W2999593549 @default.
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- W4313643485 cites W3014408964 @default.
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- W4313643485 cites W3206827823 @default.
- W4313643485 cites W4200504890 @default.
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- W4313643485 doi "https://doi.org/10.1016/j.biomaterials.2023.121995" @default.
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