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- W4313643589 abstract "Abstract The longitudinal cohort study investigated the associations of air pollutant exposures, including CO, NO, NO 2 , NO x , O 3 , PM 10 , PM 2.5 , and SO 2 , with long-term renal function changes in patients with chronic kidney disease (CKD). We enrolled 447 CKD patients who took part in a universal pre-ESRD care program during 2011–2015 at a hospital. The daily average air pollutant exposures were estimated for each patient. We defined different levels of air pollutant concentrations by quartile and rapid renal progression through annual estimated glomerular filtration rate (eGFR) slope reduction over 5 ml/min/1.73 m 2 . The average age of the study population was 77.1 ± 12.6 years, and almost a quarter of them experienced rapid renal function progression from a median eGFR of 30 ml/min/1.73m 2 at baseline during a mean follow-up time of 3.4 years. No candidate air pollutants were significantly associated with an increased likelihood of rapid renal function progression. However, it is worth noting that there was a potentially increased likelihood of fast renal function decline with raised NO quartile (adjusted odds ratio from 1.11 to 2.04). The results encourage more extensive studies to clarify the causal relationships and mechanisms between long-term air pollutant exposures and longitudinal renal function change, especially in CKD populations." @default.
- W4313643589 created "2023-01-07" @default.
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- W4313643589 date "2023-01-06" @default.
- W4313643589 modified "2023-09-29" @default.
- W4313643589 title "Associations of Air Pollutant Concentrations with Longitudinal Renal Function Changes in Patients with Chronic Kidney Disease" @default.
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- W4313643589 doi "https://doi.org/10.21203/rs.3.rs-2413338/v1" @default.
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