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- W4313643668 endingPage "1793" @default.
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- W4313643668 abstract "Point-of-care (POC) diagnostics in particular focuses on the timely identification of harmful conditions close to the patients' needs. For future healthcare these diagnostics could be an invaluable tool especially in a digitalized or telemedicine-based system. However, while paper-based POC tests, with the most prominent example being the lateral flow assay (LFA), have been especially successful due to their simplicity and timely response, the COVID-19 pandemic highlighted their limitations, such as low sensitivity and ambiguous responses. This perspective discusses strategies that are currently being pursued to evolve such paper-based POC tests toward a superior diagnostic tool that provides high sensitivities, objective result interpretation, and multiplexing options. Here, we pinpoint the challenges with respect to (i) measurability and (ii) public applicability, exemplified with select cases. Furthermore, we highlight promising endeavors focused on (iii) increasing the sensitivity, (iv) multiplexing capability, and (v) objective evaluation to also ready the technology for integration with machine learning into digital diagnostics and telemedicine. The status quo in academic research and industry is outlined, and the likely highly relevant role of paper-based POC tests in future healthcare is suggested." @default.
- W4313643668 created "2023-01-07" @default.
- W4313643668 creator A5022780622 @default.
- W4313643668 creator A5083818808 @default.
- W4313643668 date "2023-01-06" @default.
- W4313643668 modified "2023-10-10" @default.
- W4313643668 title "Progression of Paper-Based Point-of-Care Testing toward Being an Indispensable Diagnostic Tool in Future Healthcare" @default.
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- W4313643668 doi "https://doi.org/10.1021/acs.analchem.2c04442" @default.
- W4313643668 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36608282" @default.
- W4313643668 hasPublicationYear "2023" @default.
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