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• W4313643797 endingPage "e1010423" @default.
• W4313643797 startingPage "e1010423" @default.
• W4313643797 abstract "Herbicide resistance in weeds is a growing threat to global crop production. Non-target site resistance is problematic because a single resistance allele can confer tolerance to many herbicides (cross resistance), and it is often a polygenic trait so it can be difficult to identify the molecular mechanisms involved. Most characterized molecular mechanisms of non-target site resistance are caused by gain-of-function mutations in genes from a few key gene families-the mechanisms of resistance caused by loss-of-function mutations remain unclear. In this study, we first show that the mechanism of non-target site resistance to the herbicide thaxtomin A conferred by loss-of-function of the gene PAM16 is conserved in Marchantia polymorpha, validating its use as a model species with which to study non-target site resistance. To identify mechanisms of non-target site resistance caused by loss-of-function mutations, we generated 107 UV-B mutagenized M. polymorpha spores and screened for resistance to the herbicide thaxtomin A. We isolated 13 thaxtomin A-resistant mutants and found that 3 mutants carried candidate resistance-conferring SNPs in the MpRTN4IP1L gene. Mprtn4ip1l mutants are defective in coenzyme Q biosynthesis and accumulate higher levels of reactive oxygen species (ROS) than wild-type plants. Mutants are weakly resistant to thaxtomin A and cross resistant to isoxaben, suggesting that loss of MpRTN4IP1L function confers non-target site resistance. Mutants are also defective in thaxtomin A metabolism. We conclude that loss of MpRTN4IP1L function is a novel mechanism of non-target site herbicide resistance and propose that other mutations that increase ROS levels or decrease thaxtomin A metabolism could contribute to thaxtomin A resistance in the field." @default.
• W4313643797 created "2023-01-07" @default.
• W4313643797 creator A5009009442 @default.
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• W4313643797 date "2023-01-06" @default.
• W4313643797 modified "2023-10-18" @default.
• W4313643797 title "Reduced coenzyme Q synthesis confers non-target site resistance to the herbicide thaxtomin A" @default.
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• W4313643797 doi "https://doi.org/10.1371/journal.pgen.1010423" @default.
• W4313643797 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36608112" @default.
• W4313643797 hasPublicationYear "2023" @default.
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