Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313643982> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W4313643982 endingPage "S631" @default.
- W4313643982 startingPage "S630" @default.
- W4313643982 abstract "Maternal-offspring separation has adverse effects on maternal cardiovascular health in a murine model. These effects may be mediated by oxytocin (OXT), which is produced in response to both nipple stimulation and maternal-offspring interaction. We sought to quantify the effect of each of these mechanisms on maternal hypothalamic OXT production and post-partum cardiovascular (CV) parameters. Nonpregnant CD1 mice underwent baseline blood pressure (BP) and echocardiogram (ECHO) assessment. Animals then underwent thelectomy (TL, nipples surgically removed) or sham thelectomy (STL). Following pregnancy and delivery, dams were allocated to 3 conditions: 1) TL dams housed with another dam and 8 pups, maternal-pup interaction but no lactation (TL group). 2) STL dams housed with 8 pups, normal lactation (STL group). 3) STL dams separated from pups and housed alone (CTR-STL group). At 1-month post-partum, BP and ECHO were measured and normalized to baseline. OXT in plasma and hypothalamic CD38 were measured using xMAP assay and real-time RT qPCR. Results were analyzed using One-Way and Kruskal-Wallis ANOVA with appropriate post-hoc tests (P< . 05). Compared with STL dams, OXT levels (Fig1) were significantly lower in TL (P< . 01) and CTR-STL (P=0.018). CD38 gene expression, which regulates OXT, was lower in TL (P< .01) and CTR-STL (P=< . 01). These differences mirrored CV parameters: compared with STL, systolic BP (Fig2) and mean BP was significantly higher in TL (P=.03) and CTR-STL (P=.04) dams, and diastolic BP was higher in CTR-STL (P=.03) dams. Ejection fraction lower in CTR-STL (P=.02) mice. The mitral inflow E wave/tissue Doppler mitral annulus velocity (E/A) ratio was significantly lower in TL (P=.04) and CTR-STL (P=.02). Compared with normal lactation, both thelectomy and complete separation were associated with reduced OXT and deleterious CV parameters at 1 month postpartum. These results suggest that disruption of lactation, not mother-offspring interaction, mediates the effects of mother-offspring separation on CV health.View Large Image Figure ViewerDownload Hi-res image Download (PPT)" @default.
- W4313643982 created "2023-01-07" @default.
- W4313643982 creator A5000733521 @default.
- W4313643982 creator A5001091960 @default.
- W4313643982 creator A5007063740 @default.
- W4313643982 creator A5017954142 @default.
- W4313643982 creator A5019713094 @default.
- W4313643982 creator A5024721629 @default.
- W4313643982 creator A5070677123 @default.
- W4313643982 creator A5089552735 @default.
- W4313643982 date "2023-01-01" @default.
- W4313643982 modified "2023-09-27" @default.
- W4313643982 title "Effects of lactation and mother-offspring interaction on oxytocin and postpartum cardiovascular health in murine model" @default.
- W4313643982 doi "https://doi.org/10.1016/j.ajog.2022.11.1066" @default.
- W4313643982 hasPublicationYear "2023" @default.
- W4313643982 type Work @default.
- W4313643982 citedByCount "0" @default.
- W4313643982 crossrefType "journal-article" @default.
- W4313643982 hasAuthorship W4313643982A5000733521 @default.
- W4313643982 hasAuthorship W4313643982A5001091960 @default.
- W4313643982 hasAuthorship W4313643982A5007063740 @default.
- W4313643982 hasAuthorship W4313643982A5017954142 @default.
- W4313643982 hasAuthorship W4313643982A5019713094 @default.
- W4313643982 hasAuthorship W4313643982A5024721629 @default.
- W4313643982 hasAuthorship W4313643982A5070677123 @default.
- W4313643982 hasAuthorship W4313643982A5089552735 @default.
- W4313643982 hasBestOaLocation W43136439821 @default.
- W4313643982 hasConcept C112672928 @default.
- W4313643982 hasConcept C126322002 @default.
- W4313643982 hasConcept C131872663 @default.
- W4313643982 hasConcept C134018914 @default.
- W4313643982 hasConcept C2776176026 @default.
- W4313643982 hasConcept C2776659692 @default.
- W4313643982 hasConcept C2779234561 @default.
- W4313643982 hasConcept C54355233 @default.
- W4313643982 hasConcept C57900726 @default.
- W4313643982 hasConcept C71924100 @default.
- W4313643982 hasConcept C84393581 @default.
- W4313643982 hasConcept C86803240 @default.
- W4313643982 hasConceptScore W4313643982C112672928 @default.
- W4313643982 hasConceptScore W4313643982C126322002 @default.
- W4313643982 hasConceptScore W4313643982C131872663 @default.
- W4313643982 hasConceptScore W4313643982C134018914 @default.
- W4313643982 hasConceptScore W4313643982C2776176026 @default.
- W4313643982 hasConceptScore W4313643982C2776659692 @default.
- W4313643982 hasConceptScore W4313643982C2779234561 @default.
- W4313643982 hasConceptScore W4313643982C54355233 @default.
- W4313643982 hasConceptScore W4313643982C57900726 @default.
- W4313643982 hasConceptScore W4313643982C71924100 @default.
- W4313643982 hasConceptScore W4313643982C84393581 @default.
- W4313643982 hasConceptScore W4313643982C86803240 @default.
- W4313643982 hasIssue "1" @default.
- W4313643982 hasLocation W43136439821 @default.
- W4313643982 hasOpenAccess W4313643982 @default.
- W4313643982 hasPrimaryLocation W43136439821 @default.
- W4313643982 hasRelatedWork W2009428258 @default.
- W4313643982 hasRelatedWork W2035704182 @default.
- W4313643982 hasRelatedWork W2062966719 @default.
- W4313643982 hasRelatedWork W2064652474 @default.
- W4313643982 hasRelatedWork W2068318435 @default.
- W4313643982 hasRelatedWork W2088618831 @default.
- W4313643982 hasRelatedWork W2110681150 @default.
- W4313643982 hasRelatedWork W2114431169 @default.
- W4313643982 hasRelatedWork W3160140598 @default.
- W4313643982 hasRelatedWork W2407537258 @default.
- W4313643982 hasVolume "228" @default.
- W4313643982 isParatext "false" @default.
- W4313643982 isRetracted "false" @default.
- W4313643982 workType "article" @default.