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- W4313644037 abstract "Summary Lung cancer in never-smokers disproportionately affects older women. To understand the mutational landscape of this cohort, we performed detailed genome characterization of 73 lung adenocarcinomas from participants of the Women’s Health Initiative (WHI). We find enrichment of EGFR mutations in never-/light-smokers and KRAS mutations in heavy smokers as expected, but we also show that the specific variants of these genes differ by smoking status, with important therapeutic implications. Mutational signature analysis revealed signatures of clock, APOBEC, and DNA repair deficiency in never-/light-smokers; however, the mutational load of these signatures did not differ significantly from those found in smokers. Last, tumors from both smokers and never-/light-smokers shared copy number subtypes, with no significant differences in aneuploidy. Thus, the genomic landscape of lung cancer in never-/light-smokers and smokers is predominantly differentiated by somatic mutations and not copy number alterations." @default.
- W4313644037 created "2023-01-07" @default.
- W4313644037 creator A5011108891 @default.
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- W4313644037 date "2023-01-06" @default.
- W4313644037 modified "2023-10-05" @default.
- W4313644037 title "Somatic mutation but not aneuploidy differentiates lung cancer in never-smokers and smokers" @default.
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