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• W4313644479 abstract "Introduction The changing epidemiology of Clostridioides difficile reflects a well-established and intricate community transmission network. With rising numbers of reported community-acquired infections, recent studies tried to identify the role played by non-human reservoirs in the pathogen's transmission chain. This study aimed at describing the C. difficile strains circulating in canine and feline populations, and to evaluate their genetic overlap with human strains to assess the possibility of interspecies transmission. Methods Fecal samples from dogs ( n = 335) and cats ( n = 140) were collected from two populations (group A and group B) in Portugal. C. difficile isolates were characterized for toxigenic profile and PCR-ribotyping. The presence of genetic determinants of antimicrobial resistance was assessed in all phenotypically resistant isolates. To evaluate the genetic overlap between companion animals and human isolates from Portugal, RT106 ( n = 42) and RT014/020 ( n = 41) strains from both sources were subjected to whole genome sequencing and integrated with previously sequenced RT106 ( n = 43) and RT014/020 ( n = 142) genomes from different countries. The genetic overlap was assessed based on core-single nucleotide polymorphism (SNP) using a threshold of 2 SNP. Results The overall positivity rate for C. difficile was 26% (76/292) in group A and 18.6% (34/183) in group B. Toxigenic strains accounted for 50% (38/76) and 52.9% (18/34) of animal carriage rates, respectively. The most prevalent ribotypes (RT) were the toxigenic RT106 and RT014/020, and the non-toxigenic RT010 and RT009. Antimicrobial resistance was found for clindamycin (27.9%), metronidazole (17.1%) and moxifloxacin (12.4%), associated with the presence of the ermB gene, the pCD-METRO plasmid and point mutations in the gyrA gene, respectively. Both RT106 and RT014/020 genetic analysis revealed several clusters integrating isolates from animal and human sources, supporting the possibility of clonal interspecies transmission or a shared environmental contamination source. Discussion This study shows that companion animals may constitute a source of infection of toxigenic and antimicrobial resistant human associated C. difficile isolates. Additionally, it contributes with important data on the genetic proximity between C. difficile isolates from both sources, adding new information to guide future work on the role of animal reservoirs in the establishment of community associated transmission networks and alerting for potential public health risk." @default.
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• W4313644479 date "2023-01-06" @default.
• W4313644479 modified "2023-09-26" @default.
• W4313644479 title "Molecular epidemiology of Clostridioides difficile in companion animals: Genetic overlap with human strains and public health concerns" @default.
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• W4313644479 cites W1841415786 @default.
• W4313644479 cites W1968205721 @default.
• W4313644479 cites W1983608661 @default.
• W4313644479 cites W1993180979 @default.
• W4313644479 cites W2008230537 @default.
• W4313644479 cites W2046180648 @default.
• W4313644479 cites W2057316653 @default.
• W4313644479 cites W2067859765 @default.
• W4313644479 cites W2077265045 @default.
• W4313644479 cites W2084950072 @default.
• W4313644479 cites W2085946518 @default.
• W4313644479 cites W2087637929 @default.
• W4313644479 cites W2090647040 @default.
• W4313644479 cites W2091162757 @default.
• W4313644479 cites W2091810693 @default.
• W4313644479 cites W2096093282 @default.
• W4313644479 cites W2097818540 @default.
• W4313644479 cites W2102459023 @default.
• W4313644479 cites W2106800026 @default.
• W4313644479 cites W2106831385 @default.
• W4313644479 cites W2111441850 @default.
• W4313644479 cites W2118688136 @default.
• W4313644479 cites W2125087041 @default.
• W4313644479 cites W2129296397 @default.
• W4313644479 cites W2131821874 @default.
• W4313644479 cites W2135913675 @default.
• W4313644479 cites W2143325926 @default.
• W4313644479 cites W2149711482 @default.
• W4313644479 cites W2166800741 @default.
• W4313644479 cites W2225505727 @default.
• W4313644479 cites W2345791363 @default.
• W4313644479 cites W2531684910 @default.
• W4313644479 cites W2538438242 @default.
• W4313644479 cites W2549760434 @default.
• W4313644479 cites W2559809848 @default.
• W4313644479 cites W2610656577 @default.
• W4313644479 cites W2731139283 @default.
• W4313644479 cites W2733351180 @default.
• W4313644479 cites W2737773354 @default.
• W4313644479 cites W2768017947 @default.
• W4313644479 cites W2784007745 @default.
• W4313644479 cites W2787903069 @default.
• W4313644479 cites W2792519072 @default.
• W4313644479 cites W2793699100 @default.
• W4313644479 cites W2795119705 @default.
• W4313644479 cites W2888528696 @default.
• W4313644479 cites W2902065303 @default.
• W4313644479 cites W2912202586 @default.
• W4313644479 cites W2943184215 @default.
• W4313644479 cites W2949775143 @default.
• W4313644479 cites W2982531601 @default.
• W4313644479 cites W2983351185 @default.
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• W4313644479 cites W3003395627 @default.
• W4313644479 cites W3007056960 @default.
• W4313644479 cites W3022527922 @default.
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• W4313644479 doi "https://doi.org/10.3389/fpubh.2022.1070258" @default.
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• W4313644479 hasPublicationYear "2023" @default.
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