Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313644562> ?p ?o ?g. }
- W4313644562 abstract "Liver hepatocellular carcinoma (LIHC) is one of the most common liver malignancies with high mortality and morbidity. Thus, it is crucial to identify potential biomarker that is capable of accurately predicting the prognosis and therapeutic response of LIHC. Kinesin family member 5A (KIF5A) is a microtubule-based motor protein involved in the transport of macromolecules such as organelle proteins in cells. Recent studies have illustrated that the high expression of KIF5A was related to poor prognosis of solid tumors, including bladder cancer, prostate cancer, and breast cancer. However, little is currently known concerning the clinical significance of KIF5A expression in LIHC. Herein, by adopting multi-omics bioinformatics analysis, we comprehensively uncovered the potential function and the predictive value of KIF5A in stratifying clinical features among patients with LIHC, for which a high KIF5A level predicted an unfavorable clinical outcome. Results from KIF5A-related network and enrichment analyses illustrated that KIF5A might involve in microtubule-based process, antigen processing and presentation of exogenous peptide antigen via MHC class II. Furthermore, immune infiltration and immune function analyses revealed upregulated KIF5A could predict a unique tumor microenvironment with more CD8+T cells and a higher level of anti-tumor immune response. Evidence provided by immunohistochemistry staining (IHC) further validated our findings at the protein level. Taken together, KIF5A might serve as a novel prognostic biomarker for predicting immunotherapy response and could be a potential target for anti-cancer strategies for LIHC." @default.
- W4313644562 created "2023-01-07" @default.
- W4313644562 creator A5019560977 @default.
- W4313644562 creator A5030978586 @default.
- W4313644562 creator A5034493918 @default.
- W4313644562 creator A5042381848 @default.
- W4313644562 creator A5049255530 @default.
- W4313644562 creator A5052568367 @default.
- W4313644562 creator A5079585040 @default.
- W4313644562 creator A5081641600 @default.
- W4313644562 creator A5085028455 @default.
- W4313644562 creator A5085614055 @default.
- W4313644562 date "2023-01-06" @default.
- W4313644562 modified "2023-10-03" @default.
- W4313644562 title "KIF5A upregulation in hepatocellular carcinoma: A novel prognostic biomarker associated with unique tumor microenvironment status" @default.
- W4313644562 cites W1607313147 @default.
- W4313644562 cites W1889335134 @default.
- W4313644562 cites W1966522008 @default.
- W4313644562 cites W1971837077 @default.
- W4313644562 cites W1985812526 @default.
- W4313644562 cites W2052999972 @default.
- W4313644562 cites W2095866442 @default.
- W4313644562 cites W2130779727 @default.
- W4313644562 cites W2163814058 @default.
- W4313644562 cites W2166227344 @default.
- W4313644562 cites W2175387224 @default.
- W4313644562 cites W2342642001 @default.
- W4313644562 cites W2435243879 @default.
- W4313644562 cites W2514929667 @default.
- W4313644562 cites W2533508881 @default.
- W4313644562 cites W2560499218 @default.
- W4313644562 cites W2749679400 @default.
- W4313644562 cites W2787358630 @default.
- W4313644562 cites W2795989238 @default.
- W4313644562 cites W2796207838 @default.
- W4313644562 cites W2809000676 @default.
- W4313644562 cites W2937049039 @default.
- W4313644562 cites W2940178285 @default.
- W4313644562 cites W2955215257 @default.
- W4313644562 cites W2999626196 @default.
- W4313644562 cites W3000279544 @default.
- W4313644562 cites W3004163552 @default.
- W4313644562 cites W3010022505 @default.
- W4313644562 cites W3017091658 @default.
- W4313644562 cites W3082962105 @default.
- W4313644562 cites W3093530736 @default.
- W4313644562 cites W3097480917 @default.
- W4313644562 cites W3107527779 @default.
- W4313644562 cites W3134443156 @default.
- W4313644562 cites W3139511935 @default.
- W4313644562 cites W3159400409 @default.
- W4313644562 cites W3164582693 @default.
- W4313644562 cites W3188790184 @default.
- W4313644562 cites W3195406213 @default.
- W4313644562 cites W3197617774 @default.
- W4313644562 cites W3208485303 @default.
- W4313644562 cites W4210774372 @default.
- W4313644562 cites W4225957066 @default.
- W4313644562 cites W4226055469 @default.
- W4313644562 cites W4232620598 @default.
- W4313644562 doi "https://doi.org/10.3389/fonc.2022.1071722" @default.
- W4313644562 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36686769" @default.
- W4313644562 hasPublicationYear "2023" @default.
- W4313644562 type Work @default.
- W4313644562 citedByCount "0" @default.
- W4313644562 crossrefType "journal-article" @default.
- W4313644562 hasAuthorship W4313644562A5019560977 @default.
- W4313644562 hasAuthorship W4313644562A5030978586 @default.
- W4313644562 hasAuthorship W4313644562A5034493918 @default.
- W4313644562 hasAuthorship W4313644562A5042381848 @default.
- W4313644562 hasAuthorship W4313644562A5049255530 @default.
- W4313644562 hasAuthorship W4313644562A5052568367 @default.
- W4313644562 hasAuthorship W4313644562A5079585040 @default.
- W4313644562 hasAuthorship W4313644562A5081641600 @default.
- W4313644562 hasAuthorship W4313644562A5085028455 @default.
- W4313644562 hasAuthorship W4313644562A5085614055 @default.
- W4313644562 hasBestOaLocation W43136445621 @default.
- W4313644562 hasConcept C104317684 @default.
- W4313644562 hasConcept C121608353 @default.
- W4313644562 hasConcept C126322002 @default.
- W4313644562 hasConcept C127561419 @default.
- W4313644562 hasConcept C143998085 @default.
- W4313644562 hasConcept C203014093 @default.
- W4313644562 hasConcept C2776107976 @default.
- W4313644562 hasConcept C2776231280 @default.
- W4313644562 hasConcept C2777701055 @default.
- W4313644562 hasConcept C2778019345 @default.
- W4313644562 hasConcept C2780192828 @default.
- W4313644562 hasConcept C2781197716 @default.
- W4313644562 hasConcept C502942594 @default.
- W4313644562 hasConcept C55493867 @default.
- W4313644562 hasConcept C71924100 @default.
- W4313644562 hasConcept C86803240 @default.
- W4313644562 hasConcept C8891405 @default.
- W4313644562 hasConceptScore W4313644562C104317684 @default.
- W4313644562 hasConceptScore W4313644562C121608353 @default.
- W4313644562 hasConceptScore W4313644562C126322002 @default.
- W4313644562 hasConceptScore W4313644562C127561419 @default.
- W4313644562 hasConceptScore W4313644562C143998085 @default.
- W4313644562 hasConceptScore W4313644562C203014093 @default.