FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313644750> ?p ?o ?g. }

• W4313644750 abstract "Abstract Artemisia annua is the only medicinal crop to produce artemisinin for the treatment of malignant malaria. Unfortunately, hundreds of thousands of people still lose their life every year due to the lack of sufficient artemisinin. Artemisinin is considered to result from the spontaneous autoxidation of dihydroartemisinic acid in the presence of reactive oxygen species (ROS) in an oxidative condition of glandular trichomes (GTs),; however, whether increasing antioxidative compounds can inhibit artemisinin biosynthesis in plant cells is unknown. Anthocyanins are potent antioxidants that can remove ROS in plant cells. To date, no anthocyanins have been structurally elucidated from A. annua . In this study, our goals were to engineer anthocyanins in A. annua cells and to understand the artemisinin biosynthesis in anthocyanin-producing cells. Arabidopsis PAP1 ( AtPAP1 ) was used to engineer four types of transgenic anthocyanin-producing A. annua (TAPA1 to 4) cells. Three wild type cell types were developed as controls. TAPA1 cells produced the highest contents of total anthocyanins. LC-MS analysis detected 17 anthocyanin or anthocyanidin compounds. Crystallization, LC/MS/MS and NMR analyses identified cyanidin, pelargonidin, one cyanin, and one pelargonin. An integrative analysis characterized that four types of TAPA cells expressed the artemisinin pathway and TAPA1 cells produced the highest artemisinin and artemisinic acid. The contents of arteannuin B were similar in seven cell types. These data showed that the engineering of anthocyanins does not eliminate the biosynthesis of artemisinin in cells. These data allow us to propose a new hypothesis that enzymes catalyze the formation of artemisinin from DHAA in non-GT cells. These findings show a new platform to increase artemisinin production via non-GT cells of A. annua ." @default.
• W4313644750 created "2023-01-07" @default.
• W4313644750 creator A5024921005 @default.
• W4313644750 creator A5049440183 @default.
• W4313644750 creator A5061620173 @default.
• W4313644750 creator A5061834037 @default.
• W4313644750 creator A5082770801 @default.
• W4313644750 creator A5085460763 @default.
• W4313644750 date "2023-01-06" @default.
• W4313644750 modified "2023-09-26" @default.
• W4313644750 title "Metabolic engineering of anthocyanin pathway in<i>Artemisia annua</i>cells does not exclude the expression of artemisinin pathway" @default.
• W4313644750 cites W1571265670 @default.
• W4313644750 cites W1913281859 @default.
• W4313644750 cites W1963710027 @default.
• W4313644750 cites W1969943057 @default.
• W4313644750 cites W1969962785 @default.
• W4313644750 cites W1981404580 @default.
• W4313644750 cites W1982608144 @default.
• W4313644750 cites W1982718360 @default.
• W4313644750 cites W1986839267 @default.
• W4313644750 cites W1990226486 @default.
• W4313644750 cites W1997107884 @default.
• W4313644750 cites W2023533798 @default.
• W4313644750 cites W2033812623 @default.
• W4313644750 cites W2038786730 @default.
• W4313644750 cites W2045037263 @default.
• W4313644750 cites W2048471538 @default.
• W4313644750 cites W2049619062 @default.
• W4313644750 cites W2055226402 @default.
• W4313644750 cites W2057437814 @default.
• W4313644750 cites W2059921139 @default.
• W4313644750 cites W2068461509 @default.
• W4313644750 cites W2072902455 @default.
• W4313644750 cites W2075579534 @default.
• W4313644750 cites W2078283218 @default.
• W4313644750 cites W2080053579 @default.
• W4313644750 cites W2092986059 @default.
• W4313644750 cites W2101935558 @default.
• W4313644750 cites W2103878064 @default.
• W4313644750 cites W2104781222 @default.
• W4313644750 cites W2119946908 @default.
• W4313644750 cites W2129447528 @default.
• W4313644750 cites W2132259321 @default.
• W4313644750 cites W2144917006 @default.
• W4313644750 cites W2146420365 @default.
• W4313644750 cites W2149202606 @default.
• W4313644750 cites W2163327181 @default.
• W4313644750 cites W2165071298 @default.
• W4313644750 cites W2167368939 @default.
• W4313644750 cites W2222510962 @default.
• W4313644750 cites W2228665180 @default.
• W4313644750 cites W2315948853 @default.
• W4313644750 cites W2328790886 @default.
• W4313644750 cites W2395149628 @default.
• W4313644750 cites W2401818449 @default.
• W4313644750 cites W2547697324 @default.
• W4313644750 cites W2557659496 @default.
• W4313644750 cites W2559821950 @default.
• W4313644750 cites W2592552134 @default.
• W4313644750 cites W2892553494 @default.
• W4313644750 cites W2902113343 @default.
• W4313644750 cites W2921919158 @default.
• W4313644750 cites W2951197366 @default.
• W4313644750 cites W3118305633 @default.
• W4313644750 cites W3177250754 @default.
• W4313644750 cites W3193550763 @default.
• W4313644750 cites W3215684596 @default.
• W4313644750 cites W4220908512 @default.
• W4313644750 cites W4281658377 @default.
• W4313644750 cites W4294577376 @default.
• W4313644750 cites W4297216037 @default.
• W4313644750 cites W4304687497 @default.
• W4313644750 cites W4376848759 @default.
• W4313644750 doi "https://doi.org/10.1101/2023.01.05.522882" @default.
• W4313644750 hasPublicationYear "2023" @default.
• W4313644750 type Work @default.
• W4313644750 citedByCount "0" @default.
• W4313644750 crossrefType "posted-content" @default.
• W4313644750 hasAuthorship W4313644750A5024921005 @default.
• W4313644750 hasAuthorship W4313644750A5049440183 @default.
• W4313644750 hasAuthorship W4313644750A5061620173 @default.
• W4313644750 hasAuthorship W4313644750A5061834037 @default.
• W4313644750 hasAuthorship W4313644750A5082770801 @default.
• W4313644750 hasAuthorship W4313644750A5085460763 @default.
• W4313644750 hasBestOaLocation W43136447501 @default.
• W4313644750 hasConcept C185592680 @default.
• W4313644750 hasConcept C203014093 @default.
• W4313644750 hasConcept C2776120307 @default.
• W4313644750 hasConcept C2777278459 @default.
• W4313644750 hasConcept C2778048844 @default.
• W4313644750 hasConcept C2778371730 @default.
• W4313644750 hasConcept C2778945092 @default.
• W4313644750 hasConcept C2779691961 @default.
• W4313644750 hasConcept C2910462512 @default.
• W4313644750 hasConcept C31903555 @default.
• W4313644750 hasConcept C48349386 @default.
• W4313644750 hasConcept C55493867 @default.
• W4313644750 hasConcept C86803240 @default.
• W4313644750 hasConceptScore W4313644750C185592680 @default.
• W4313644750 hasConceptScore W4313644750C203014093 @default.

• next